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| Number | Title | Issue Date |
| 6248306 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polymer complexes containing a) complexing ligands of general formula I A--{X--[Y--(Z--( W--Kw)z)y ]x }a (I) in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, ind... | 06/19/2001 |
| 5472854 | Process for the production of 17-oxosteroids via the fermentative oxidation of 17ଲ-hydroxysteroids by Mycobacterium A process for the production of 17-oxosteroids by fermentative oxidation of 17ଲ-hydroxy steroids is described, which is characterized in that for the fermentation, a bacterial culture of the species Mycobacterium spec. NRRL B-3805, Mycobacterium spe... | 12/05/1995 |
| 5450847 | Process for making doses formulation of contrast media from concentrate The invention relates to a process for preparing pharmaceutically acceptable dosage forms of contrast medium from concentrated contrast medium using a fluid delivery system suitable for removing predetermined amounts of fluids from a plurality of vessels ... | 09/19/1995 |
| 5446035 | 20-methyl-substituted vitamin D derivatives New 20-methyl-substituted vitamin D derivatives of general formula I ##STR1## are described in which R1 means a hydrogen atom, a hydroxy group or an alkanoyloxy group with 1 to 12 carbon atoms or a benzoyloxy group, R2 means a hydrog... | 08/29/1995 |
| 5446036 | 13-alkyl-11beta-phenylgonanes There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R2 is alpha- or beta-position methyl or ethyl; R1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl r... | 08/29/1995 |
| 5446178 | Process for preparing 19,11ଲ-bridged steroids A process of cyclizing compounds of formula II ##STR1## wherein K, V', R1 and 1 are as herein defined, is described whereby a compound of formula IVa is produced ##STR2## wherein K, V', R1, Q, S and 1 are as herein defined.... | 08/29/1995 |
| 5439913 | Contraception method using competitive progesterone antagonists and novel compounds useful therein Competitive progesterone antagonists, including two novel steroids, viz., 11ଲ,19-[4-(cyanophenyl)-o-phenylene]-17ଲ-hydroxy-17-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one and 11ଲ,19-[4-(3-pyridinyl)-o-phenylene]-17ଲ-hydroxy-1... | 08/08/1995 |
| 5440044 | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents The present invention relates to a leukotriene-B4 analog according to formula I ##STR1## in which R1 is a COOR2 group, wherein R2 is a C2-4 -alkyl group; B is a C1-3 -alkylene group, a... | 08/08/1995 |
| 5439902 | 14, 16-ethanoand 14, 16-etheno-estratrienes The new 14,16-ethano- and 14,16-etheno-estratrienes of general formula I, ##STR1## are described, in which A-B means a C-C single bond or C-C double bond, R1 means a hydrogen atom, a methyl or acyl group with 1-12 ca... | 08/08/1995 |
| 5432170 | Process for the production of semisolid preparations containing micronized active ingredients A process for the production of semisolid preparations containing micronized active ingredients is described which is characterized in that a mixture of one or two nonionic surfactants with an HLB of 9 to 18 with 2.3 to 100 times the amount by weight of a... | 07/11/1995 |
| 5429934 | Process for the production of 20-methyl-5,7-pregnadiene-3ଲ,21-diol derivatives using mycobacterium 20 -Methyl-5,7-pregnadiene-3ଲ,21-diol derivatives of general formula I ##STR1## in which R1 means a hydrogen atom or a lower alkyl group and R2 means a lower alkyl group or R1 and R2 together represent a tetram... | 07/04/1995 |
| 5426102 | 14ଲ-H-, 14-and 15-En-11ଲ-aryl-4-oestrenes Novel compounds of the general formula I ##STR1## and the pharmacologically tolerable addition salts thereof with acids are described, in which either Ia) R11 represents a hydrogen atom in the ଲ-configuration and each of R12 | 06/20/1995 |
| 5425366 | Ultrasonic contrast agents for color Doppler imaging The invention relates to a method for obtaining an ultrasonic image of a patient with ultrasonic color Doppler modality with microparticulate ultrasonic contrast agents in regions where the ultrasonic contrast agents are essentially motionless.... | 06/20/1995 |
| 5419894 | Complexing agents, complexes and complex salts Compounds of the general formula I: ##STR1## wherein R1 signifies a COOX group or the group ##STR2## R2 and R3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarb... | 05/30/1995 |
| 5418227 | 14,16ଲ-ethano-15ଲ, 16(1)-cyclo-14ଲ-estra-1,3,5(10)-trienes 14,16ଲ-Ethano-15ଲ,161 -cyclo-14ଲ-estra-1,3,5(10)-trienes of general formula I ##STR1## in which R1 means a hydrogen atom, a C1 to C9 alkyl or C1 to C9 acyl radical, R... | 05/23/1995 |
| 5418145 | Process for the preparation of 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione A process is claimed for the preparation of 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione of the general formula ##STR1## wherein symbolizes a single bond or a double bond, characterized by fermenting -sitosterol with a culture o... | 05/23/1995 |
| 5414002 | 5- or 6-substituted ଲ-carboline-3-carboxylic acid esters 5- or 6-substituted ଲ-carboline-3-carboxylic acid esters of Formula I ##STR1## wherein R1 is hydrogen, nitrilo, halogen, lower alkyl or lower alkoxy, and R3 is a branched C3-6 alkyl group which is optionally substitu... | 05/09/1995 |
| 5414016 | New leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents Leukotriene-B4 derivatives of formula I ##STR1## are described, in which R1 means CH2 OH, CH3, CF3, COOR5, CONR6 R7, or R1 together with R2 means... | 05/09/1995 |
| 5411982 | Cycloalkylene azoles, and their use as aromatase inhibitors The disclosure relates to cycloalkylene azoles of general Formula I ##STR1## wherein ##STR2## is a carbocyclic or carbopolycyclic group optionally carrying at least on a alkyl substituent, X is a grouping ##STR3## an oxygen or sulf... | 05/02/1995 |
| 5411949 | 23-oxa-derivatives in the vitamin D series, process for their production, pharmaceutical preparations containing these derivatives as well as their use pharmaceutical agents 23-Oxa-derivatives in the vitamin D series of formula I ##STR1## are described in which R1, R2 and R4 independently of one another mean a hydrogen atom or an acyl group with 1 to 9 carbon atoms, R3 each means a ... | 05/02/1995 |
| 5410516 | Ultrasonic processes and circuits for performing them A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein a material is introduced in the examina... | 04/25/1995 |
| 5410043 | Process for the production of mono-N-substituted tetraaza macrocycles A new process for the production of mono-N-substituted tetraaza macrocycles, N-substituted-tri-N-carboxyalkyl tetraaza macrocycles, and/or metal complexes thereof is described.... | 04/25/1995 |
| 5407928 | 11ଲ-aryl-gona-4,9-dien-3-ones This invention relates to 11ଲ-aryl-gona-4,9-dienes of the general formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone antagonists and are suitable for inducing labor or an abortion.... | 04/18/1995 |
| 5405979 | Process for the production of 10ଲ-H-steroids A process for the production of 10ଲ-H-11ଲ-(substituted phenyl) steroids of the formulae Ia or Ib set forth in the claims by reduction of a compound of the formula III: ##STR1## followed by cleaving with a strong acid or partial cleaving w... | 04/11/1995 |
| 5403724 | Microbiological reduction of prostacyclin intermediate products with a 15-keto group A process for production of 15-alpha-hydroxyprostaglandin intermediates of formula I ##STR1## wherein X is CH2, A is trans --CH.dbd.CH-- B is ethylenedioxy or 2,2-dimethylpropylenedioxy, R1 is benzoyl, and R2 is ##STR... | 04/04/1995 |
| 5403572 | Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.... | 04/04/1995 |
| 5401748 | 2,14-disubstituted ergolines, their production and use in pharmaceutical compositions 2,14-Disubstituted ergolines of formula I ##STR1## in which R, R2, R6, R14 and X have the meaning named in the application, as well as their production and use in pharmaceutical agents, are described.... | 03/28/1995 |
| 5401854 | Process for the production of indole derivatives A process for the production of indole derivatives, which is characterized in that in the presence of phosphoric acid a substitution with an imine is performed, and intermediate products of this process and the production of these intermediate products ar... | 03/28/1995 |
| 5399340 | Use of amide complex compounds Complex compounds of general Formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of at least one element of atomic numbers 21-29, 42, 44 or 58-70, with at least two of the substituents X representing a metal ion equivalent, ... | 03/21/1995 |
| 5399355 | Agent for transdermal administration containing ergoline derivatives An agent for transdermal administration contains ergoline derivatives optionally in combination with one or more penetration-enhancing agent or agents.... | 03/21/1995 |
| 5397344 | Methods of and apparatus for measuring uterine electrical and mechanical activity The existence of gap junctions between cells is detected by stimulating the cells with electrical pulses having selective parameters and then detecting propagated signals emitted by the cells. A needle is provided having stimulation electrodes thereon fro... | 03/14/1995 |
| 5391778 | 2-iodo-3-keto-Ɗ4 steroids, process for their production, as well as their further processing The new intermediate products of general formula I ##STR1## in which R1 stands for a hydrogen atom or a straight-chain or branched alkyl group with 1 to 4 carbon atoms, R2 stands for a hydrogen atom or a methyl group, R3 s... | 02/21/1995 |
| 5389624 | Antiandrogenic [3,2-c]pyrazole and [3,2-d]triazole steroids [3,2-c]Pyrazole and [3,2-d]triazole steroids are useful anti-androgens.... | 02/14/1995 |
| 5386028 | Process for the production of N-ଲ-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-ଲ-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradeca ne derivatives and their metal complexes A process for the production of N-ଲ-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-ଲ-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetrade cane derivatives and their metal complexes is described.... | 01/31/1995 |
| 5385943 | Use of topically applicable preparations for treatment of presbyderma The invention relates to the use of topically applicable preparations containing alpha,omega-n-alkanedicarboxylic acids with 7 to 13 carbon atoms, their physiologically compatible salts or their esters cleavable by means of enzymes of the skin, as active ... | 01/31/1995 |
| 5385903 | Pharmaceutical agent for treatment of withdrawal symptoms The use of the non-NMDA receptor antagonists quisqualate or kainate antagonists or their physiologically compatible salts for treatment of withdrawal symptoms after drug abuse as well as the combination of the new pharmaceutical agents with NMDA antagonis... | 01/31/1995 |
| 5380411 | Ultrasound or shock wave work process and preparation for carrying out same The invention relates to a shock wave or ultrasound work process wherein shock wave or ultrasound generators are used to produce shock waves or ultrasound in a medium in which an effect is to be achieved, wherein to this medium is added a preparation whic... | 01/10/1995 |
| 5376683 | Ɗ8- and Ɗ9-prostaglandin derivatives, process for their production and their pharmaceutical use The invention relates to Ɗ8 - and Ɗ9 -prostaglandin derivatives of formula I, ##STR1## in which means the radicals or , R1 means ##STR2## COOR4 or CONHR5, R2 and R3 | 12/27/1994 |
| 5374654 | 9-substituted carbacyclin derivatives, processes for their preparation, and their use as medicinal agents The invention relates to carbacyclin derivatives of Formula I ##STR1## wherein the various substituents are defined herein, including, inter alia, if R2 is a hydrogen atom, their salts with physiologically compatible bases, their cyclodext... | 12/20/1994 |
| 5374745 | Process for the synthesis of propargyl alcohols and their use for production of prostaglandin precursors The invention relates to a process for the production of prostaglandin precursors of formula I ##STR1## as well as their enantiomers in which X is A--W or W--A, A is a --C.tbd.C-- group, W is a hydroxymethylene group, in which the OH group can be function... | 12/20/1994 |
