Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7511059 | Thiazolidinones, their production and use as pharmaceutical agents The invention relates to thiazolidinones of general formula (I) their production and use as inhibitors of polo-like kinases (Plk) for treating various diseases. ... | 03/31/2009 |
| 7507725 | Compounds with sulphonamide group and pharmaceutical compositions containing these compounds The invention relates to compounds which, acting as a prodrug and/or support, enable an active agent to be taken up by the erythrocytes and/or an active agent to bind to the erythrocytes. The uptake of these compounds by and/or the binding thereof to the erythrocyte... | 03/24/2009 |
| 7488468 | Near infrared fluorescent contrast agent and fluorescence imaging A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living ... | 02/10/2009 |
| 7482498 | Device and process for nucleophilic fluorination The invention relates to a device and a process for nucleophilic fluorination of a substance, especially for synthesis of an 18F-labeled substance for examination using a positron emission tomograph. The device comprises an anion exchange device (102 | 01/27/2009 |
| 7481993 | Chelators for radioactively labeled conjugates comprising a stabilizing sidechain The invention relates to a conjugate PT comprising (a) a peptide P and (b) a targeting moiety T; wherein the peptide P contains from 4 to 20 amino acid residues with optionally a single thiol moiety at the C- or N-terminus replaci... | 01/27/2009 |
| 7468470 | Medicinal patch that leaves less adhesive residue when removed The medicinal patch for delivering a pharmaceutically effective ingredient by contact with skin has a backing layer (1), an effective-ingredient containing adherent layer (2) on the backing layer and a release layer (4) applied over the adherent... | 12/23/2008 |
| 7462718 | Process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate and high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate A process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate as well as rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate at a purity of at least ... | 12/09/2008 |
| 7459470 | N-oxide anthranylamide derivatives and their use as medicaments Substituted N-oxidanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds according to the invention can be used as or in the case of psoriasis, Ka... | 12/02/2008 |
| 7442794 | Rearranged pentanols, a process for their production and their use as anti-inflammatory agents The invention relates to the compounds of formula I, a process for their production and their use as anti-inflammatory agents. ... | 10/28/2008 |
| 7435757 | 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula I in which R2 means a C1-C8-alkyl group, a C1-C | 10/14/2008 |
| 7427390 | Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with re... | 09/23/2008 |
| 7419972 | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula I as well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for prophylaxis and/or therapy of... | 09/02/2008 |
| 7417066 | Inhibitors of soluble adenylate cyclase The invention relates to compounds of general Formula I, the production thereof, and the use thereof as a medicinal product. ... | 08/26/2008 |
| 7416866 | Process for the overexpression of dehydrogenases A process for the overexpression of dehydrogenases, especially for the overexpression of Δ1-dehydrogenases, in particular for the overexpression of 3-keto steroid-Δ1-dehydrogenases, as well as for the bacteria, plasmids and DNA sequences that... | 08/26/2008 |
| 7417056 | 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents. ... | 08/26/2008 |
| 7414043 | 9-α-substituted estratrienes as selectively active estrogens This invention describes the new 9α-substituted estratrienes of general formula I in which R3, R7, R7′, R13, R16 as well as R17 and R17′ have... | 08/19/2008 |
| 7408060 | Nonsteroidal progesterone receptor modulators This invention relates to nonsteroidal progesterone receptor modulators of general formula I, a process for their production, the use of progesterone receptor modulators for the production of pharmaceutical agents as well a... | 08/05/2008 |
| 7385054 | Trimeric, macrocyclically substituted halo-benzene derivatives The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media. ... | 06/10/2008 |
| 7378406 | Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases The present invention relates to methods and uses for preventing or treating hormone-dependent disease, in particular breast cancer, in a mammal by antiprogestins, in particular antiprogestin 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra... | 05/27/2008 |
| 7375098 | 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes This invention relates to 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes of general formula I with ERβ-antagonistic activity, process for their production, their intermediate products, pharmaceutical preparat... | 05/20/2008 |
| 7355067 | Process for the production of triiodotrimesic acid A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described. ... | 04/08/2008 |
| 7344704 | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as... | 03/18/2008 |
| 7338958 | Sulfoximine-substituted pyrimidines as CDK-and/or VEGF inhibitors, their production and use as pharmaceutical agents This invention relates to pyrimidine derivatives of general formula I in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, ... | 03/04/2008 |
| 7329753 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors. ... | 02/12/2008 |
| 7326798 | Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds. ... | 02/05/2008 |
| 7316343 | Folding box with fold-down attachment flap A sealable folding box in the shape of a parallelepiped or cube with attached bottom and cover flaps and an attachment flap—is provided with an attachment recess—is that is arranged on an edge of the folding box body that extends between these flaps. To this end... | 01/08/2008 |
| 7288547 | CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents This invention relates to 2-heteroaryl-pyrimidine derivatives of general formula I or If as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases. ... | 10/30/2007 |
| 7282345 | C-erbB-2 external domain: GP75 Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quant... | 10/16/2007 |
| RE39862 | Unsaturated 14, 15-cyclopropanoandrostanes, a method for their production and pharmaceutical compositions containing these compounds The invention relates to new unsaturated 14,15-cyclopropano-androstanes of the general formula (I) to their synthesis and to pharmaceutical compositions, containing these compounds. The compounds of formula (I) have gesta... | 09/25/2007 |
| 7268241 | Method for the production of 4-(17$g(a)-methyl substituted 3-oxoestra-4 9-dien-11$g(b)-yl)benzaldehyd-(1e or 1z)-oximes The invention relates to a process for the production of 4-(17α-methyl-substituted 3-oxoestra-4,9-dien-11β-yl)benzaldehyde-(1E or 1Z)-oximes of general formula (I), in which R1 is a hydrogen atom, a C1-6-alkyl radical or a CnF... | 09/11/2007 |
| 7268140 | Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory... | 09/11/2007 |
| RE39754 | Benzamide derivatives and pharmaceutical compositions containing same The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune... | 07/31/2007 |
| 7238707 | Substituted pentanols, a process for their production and their use as anti-inflammatory agents The invention relates to substituted pentanols, a process for their production and their use as anti-inflammatory agents. ... | 07/03/2007 |
| 7235561 | Compound and a composition including such a compound This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kin... | 06/26/2007 |
| 7214808 | Method for the production of 4-(17α-substituted-3-oxoestra-4,9-dien-11β-yl)benzaldehyde-(1E)-oximes The invention relates to a method for the production of 4-(17α substituted 3-oxoestra-4,9-dien-11β-yl)benzaldehyd-(1E or 1Z)-oximes of general formula (I), where R1═H, C1-6 alkyl or a CnF2n+1 group; R2═C | 05/08/2007 |
| 7208139 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable comp... | 04/24/2007 |
| 7199115 | 17α-fluorosteroids, pharmaceutical compositions containing 17α-fluorosteroids and a method of making them New 17α-fluorosteroid compounds of formula (I) are disclosed: wherein R1 denotes H or methyl; R2 and R3 each denote H, Cl or methyl; and either a double bond or a single bond is ... | 04/03/2007 |
| 7196202 | 1-aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the pr... | 03/27/2007 |
| 7192942 | Process for production of crystals of 11μ-benzaldoxim-estra-4,9-diene derivatives, crystals obtained thereby and pharmaceutical preparations containing them The process for making crystals of a 11 β-benzaldoxim-estra-4,9-diene derivative having an average particle size of from 3 μm to 25 μm and a maximum particle size of 100 μm, includes subjecting a supersaturated solution containing a special 11β-benzaldoxim-estr... | 03/20/2007 |
| 7189879 | Process for the production of 1-hydroxymethyl-1,3,5-triazapentane, trihydrochloride A new process for the production of 1-hydroxymethyl-1,3,5-triazapentane, trihydrochloride is described. ... | 03/13/2007 |
