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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8153637 | Phenyl-alkyl piperazines having TNF-modulating activity, preparation method, and therapeutic use thereof The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutica... | 04/10/2012 |
| 8088808 | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). Wherein R, R1, R2, R3 and R4 are as described herein. More s... | 01/03/2012 |
| 6218414 | Use of an angiotensin II antagonist and a benzofuran derivative in the treatment of cardiovascular complaints The invention relates to the use of an angiotensin II antagonist and a benzofuran derivative with antiarrhythmic activity in the treatment of cardiovascular complaints, in particular in the treatment of cardiac insufficiency.... | 04/17/2001 |
| 6172239 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharamaceutical compositions containing them The invention relates to compounds of the formula ##STR1## The compounds have agreat affinity for the neurotensin receptors.... | 01/09/2001 |
| 6143778 | Pharmaceutical amiodarone composition for parenteral delivery The invention relates to a pharmaceutical composition for parenteral administration, characterized in that it comprises: from 1.5 to 8% by weight of an active principle consisting of amiodarone or one of the pharmaceutically acceptable salts thereof a physiolo... | 11/07/2000 |
| 6124316 | Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools A compound of formula: ##STR1## in which: Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C1 -C4)alkoxy; R1 represents a methyl group; R11 represents hyd... | 09/26/2000 |
| 6114336 | Cosmetic composition containing a neuropeptide Y receptor antagonist This invention relates to a cosmetic composition containing at least one NPY-antagonist component mixed with an excipient for cosmetic preparations.... | 09/05/2000 |
| 6057318 | Heterocyclic derivatives, process for their preparation and their therapeutic use The invention relates to compounds of formula: ##STR1## in which: A is selected from O or S; B is selected from C or N; Z1 is selected from C1 -C4 alkylene or phenylene; Z2 is C1 -C4 alkylene; W... | 05/02/2000 |
| 6022856 | Type-2 neurotensin receptor (NT-R2) This invention relates to a purified polypeptide which constitutes the type-2 neurotensin receptor (NT-R2), as well as the nucleotide sequence encoding this polypeptide.... | 02/08/2000 |
| 6017762 | Cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica The present invention relates to a new cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica, to a strain of this species transformed with this cassette, to a process for preparing endothiapepsin using this strain and also... | 01/25/2000 |
| 6013648 | CB2 Receptor agonist compounds The use of human CB2 receptor-specific agonists of formula (I) or (I') for preparing immunomodulating drugs is disclosed. In formulae (I) and (I'), R1 is a group selected from --CH2 CHR10 NR6 R11... | 01/11/2000 |
| 6010716 | Pharmaceutical composition for transdermal administration The invention concerns a pharmaceutical composition for transdermal administration, characterized in that it comprises: a) optionally, a polymeric release matrix capable of forming a flexible film after drying, chosen from cellulose polymers or copolymers or ... | 01/04/2000 |
| 6011154 | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH | 01/04/2000 |
| 6004761 | Method for detecting cancer using monoclonal antibodies to new mucin epitopes Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sourc... | 12/21/1999 |
| 5994348 | Pharmaceutical compositions containing irbesartan Pharmaceutical compositions containing irbesartan, alone or in combination with a diuretic, providing tablets with a high relative amount of active agent and excellent wetting and disintegration properties.... | 11/30/1999 |
| 5989578 | Associations of active principles containing clopidogrel and an antithrombotic agent The invention relates to a pharmaceutical composition containing an association of active principles, wherein the active principles are clopidogrel and aspirin, each constituent being present in a free form or in the form of a pharmaceutically acceptable ... | 11/23/1999 |
| 5985915 | Use of antiarrhythmic compounds in the prevention of post-infarction mortality The subject of the invention is a method for reducing mortality of cardiac origin in patients having a reduced left ventricular function after myocardial infarction, without rhythm disorders requiring an antiarrhythmic treatment, consisting in administeri... | 11/16/1999 |
| 5981754 | 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity The present invention relates to the compounds of formula (I) ##STR1## wherein Y is --CH-- or --N--; R1 is hydrogen, a halogen or a CF3, (C3 -C4)alkyl or (C1 -C4)alkoxy group; R2 | 11/09/1999 |
| 5977359 | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH | 11/02/1999 |
| 5977118 | 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones and compositions and methods of use thereof 6-Substituted pyrazolo[3,4-d]pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or hypertension.... | 11/02/1999 |
| 5965579 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them The invention relates to compounds of the formula: ##STR1## Compounds of the above formula have a great affinity for the neurotensin receptors.... | 10/12/1999 |
| 5965580 | Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula ##STR1## used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P- and neurokinin-dep... | 10/12/1999 |
| 5955456 | Injectable pharmaceutical composition comprising ursodesoxycholic acid or tauroursodesoxycholic acid, a strong base and tromethamol Injectable aqueous composition comprising ursodeoxycholic acid or tauroursodeoxycholic acid, a strong base compatible with intravenous injection and trometamol.... | 09/21/1999 |
| 5955474 | Use of neurotensin antagonists for the treatment of edematous conditions This invention relates to the treatment of edematous conditions in an animal by administering a neurotensin antagonist having diuretic activity.... | 09/21/1999 |
| 5942523 | Compounds which are selective antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools A compound of formula: in which: Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C1 -C4)alkoxy; R1 represents a methyl group; R11 represents hydrogen; or R1 | 08/24/1999 |
| 5939411 | Piperidine derivatives process for obtaining them and pharmaceutical compositions containing them Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula ##STR1## used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P- and neurokinin-dep... | 08/17/1999 |
| 5939449 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them The invention relates to compounds of the formula: ##STR1## The compounds have great affinity for the neurotensin receptors.... | 08/17/1999 |
| 5936123 | Hydrazine derivative compounds as intermediates for preparing substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors This invention relates to intermediate compounds which are useful for making substituted 1-phenyl-3-pyrazolecarboxamides. The compounds of the invention have the formula: ##STR1## in which: R'2 and R'3 each independently represe... | 08/10/1999 |
| 5925768 | 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity The present invention relates to compounds of the formula ##STR1## in which: X1 is a group --NR1 R2 or a group --OR2 ; g2, g3, g4, g5, g6 and w2, w | 07/20/1999 |
| 5900431 | Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections The invention relates to the use of fumagillol and the esters formed by fumagillol and saturated or unsaturated (C1 -C12) alkylcarboxylic or (C1 -C12) alkyldicarboxylic acids, and their pharmaceutically acceptab... | 05/04/1999 |
| 5891894 | Heterocyclic derivatives process for their preparation and their therapeutic use The invention relates to compounds of formula: ##STR1## in which: A is selected from 0 or S; B is selected from C or N; Z1 is selected from C1 -C4 alkylene or phenylene; Z2 is C1 -C4 a... | 04/06/1999 |
| 5891893 | Heterocyclic derivatives, process for their preparation and their therapeutic use The invention relates to compounds of formula: ##STR1## in which: A is selected from O or S; B is selected from C or N; Z1 is selected from C1 -C4 alkylene or phenylene; Z2 is C1 -C4 alkylene; W... | 04/06/1999 |
| 5892024 | Bifunctional nucleosides, oligomers thereof, and methods of making and using the same Disclosed are novel bifunctional nucleoside analogs and oligonucleosides of 3-4 bases (trimers and tetramers) and longer containing at least two consecutive internucleoside linkages of two carbon-one nitrogen atom or two carbon-one oxygen atom (3'-NCC-5',... | 04/06/1999 |
| 5880135 | Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them A compound, as well as its stereoisomers and addition salts, possssing antagonist activity with respect to corticotropin releasing hormone (CRF) has the formula: ##STR1## in which R1, and R21 which are identical or different, ar... | 03/09/1999 |
| 5877321 | Dialkylenepiperidino compounds and their enantiomers, process for preparing them and pharmaceutical compositions containing them A compound of formula XXII ##STR1## wherein Ar', Q' and Q" are as defined in the specification are useful intermediates for making neurokinin receptor active compounds.... | 03/02/1999 |
| 5869663 | Substituted heterocyclic compounds The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH | 02/09/1999 |
| 5859029 | Heterocyclic compounds method of preparing them and pharmeutical compositions in which they are present This invention relates to compounds with strong affinity for NK1 receptor and useful for preparing drugs for treating substance P-dependent pathological conditions having the formula ##STR1## in which: m is two or three; n is 0; Am is a gr... | 01/12/1999 |
| 5859340 | Recombinant gene coding for a protein having endochitinase activity Recombinant gene coding for a protein having endochitinase activity or for a precursor thereof which comprises the sequence of SEQ ID NO:1 below: Gly Gly Asp Leu Gly Ser VaL Ile Ser Asn Ser Met Phe Asp Gln Met Leu Lys His Arg Asn Glu Asn Ser Cys Gln Gly Lys As... | 01/12/1999 |
| 5856142 | Method for the extraction of periplasmic proteins from prokaryotic microorganisms in the presence of arginine The invention relates to a method for the extraction of recombinant periplasmic proteins wherein arginine is used as the extraction agent. In particular, the invention relates to a method for the extraction of a periplasmic protein of interest, which esse... | 01/05/1999 |
| 5852044 | Use of NK1 receptor antagonists for preparing cardio-regulatory drugs The invention relates to the use of NK1 receptor antagonists for the preparation of drugs with a cardioregulatory action, intended in particular for controlling heart rate disorders and cardiac dysrhythtmia.... | 12/22/1998 |
