Assignee: Sankyo Company, Limited

Location: Tokyo, JP
No. of patents: 564

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Number	Title	Issue Date
8106079	Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same A compound having the following formula (III) wherein R2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen, and a method for preparing said compound.	01/31/2012
8067396	Amino alcohol compounds or phosphonic acid derivatives thereof A compound having a formula II(a): wherein R1 and R2 are hydrogen lower alkyl, lower aliphatic acyl, or lower alkoxycarbonyl; R4 is C1-C4 alkyl; n is 2 or 3; X is a for...	11/29/2011
7994152	Method of treating a cancer by administering A 2′,5′-oligoadenylate analog A method of treating a tumor or a viral disease by administering to a human the following 2′,5′-oligoadenylate analog: Wherein m is 0; n is 0 or 1; R1 is alkoxy substituted by hydroxyl, mercapto, alkylthio su...	08/09/2011
7910617	Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound A method for suppressing the number of peripheral blood lymphocytes involving administering to a human in need thereof a pharmaceutically effective amount of a compound which is (2R) -2-amino-2-methyl-4-{1-methyl-5-[4-(4-methylphenyl)butanoyl]pyrrol-2-yl}butan-1-ol ...	03/22/2011
7906639	Oligonucleotides having a 2′-O,4′-C-ethylene nucleotide in the third position of the 3′-end The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural...	03/15/2011
7863243	Anti-tumor agent The present invention provides a new anti-tumor agent containing adiponectin as an active ingredient, particularly, an anti-tumor agent capable of inhibiting carcinogenesis in the liver, use of adiponectin as an anti-tumor agent, and a prophylactic or therapeutic me...	01/04/2011
7816552	Intermediate of 6-substituted 1-methyl-1-H-benzimidazole derivative and method for producing same A method for preparing a compound having the following formula (I) by reducing a nitro group of the following formula (III) followed by carrying out an intramolecular dehydration ...	10/19/2010
7811556	Polymeric modifiers and pharmaceutical compositions A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R1 and R2 a...	10/12/2010
7803595	Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof Nucleic acids encoding mouse and human sphingosine kinase type 2 isoforms, methods for detecting agents or drugs which inhibit or promote sphingosine activity and therapeutic agents containing peptides or antibodies to peptides encoded by such nucleic acids. ...	09/28/2010
7651999	2′, 5′-oligoadenylate analogs A 2-5A analog represented by the formula (1): wherein m is 0 or 1; n is 0 to 2; R1 represents an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto gr...	01/26/2010
7638551	Amino alcohol compounds or phosphonic acid derivatives thereof A method for the prevention or treatment of an immunology-related disease, which is not rheumatoid arthritis or psoriasis, in a mammal in need thereof which involves administering to the mammal a pharmaceutically effective amount of a compound, a pharmacologically a...	12/29/2009
7592140	2′, 5′-oligoadenylate phosphodiesterase Polypeptides having 2′,5′-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the polynucleotides have been inserted, host cells transformed by the recom...	09/22/2009
7560549	Sulfonyloxy derivatives A compound having the formula (I) wherein R1 is a substituted phenyl, R2 is a phenyl substituted with halogen atoms, R3 is a substituted phenyl, D is an oxygen or a methylene, and n is 0 or ...	07/14/2009
7547790	Optically active 4,4-di-substituted oxazolidine derivative and method for producing same An optically active 4,4-di-substituted oxazolidine compound having the formula (I) wherein R1 represents a substituted C1-C3 alkyl group, a substituted C2...	06/16/2009
7534782	Crystal of 1-methylcarbapenem solvate A 1-methylcarbapenem compound ethanolate of the formula (I-1) in the crystalline form that shows main peaks at interplanar spacings d=7.60, 6.69, 6.33, 6.14, 5.15, 4.58 and 4.48 in the X-ray powder diffraction pattern obtained with Cu Kα irradiation ...	05/19/2009
7419814	Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine kinase type 2 isoform is produced in the cell, adding at least one drug ...	09/02/2008
7417052	Phenylene derivative having tetrazole ring or thiazolidinedione ring The present invention provides a compound represented by the following formula (I) wherein A is a cyclic group etc., B is a 1H-tetrazol-5-yl group or a 2,4-dioxothiazolidin-5-yl group, and Y is a single bond or a C6-10 aryl...	08/26/2008
7411095	Process for production of high-purity enamines A method for producing highly pure enamines, which comprises reacting an aldehyde or ketone with an amine and treating the resulting reaction mixture with an acidic aqueous solution at a temperature between 0° C. and 30° C. ...	08/12/2008
7396930	Process for producing cyclic thioether and synthetic intermediate thereof A process for producing cyclic thioether compounds and their synthetic intermediates. The process produces a compound represented by formula (5): wherein G1 is an alkylene group, R1 is a thiol protecti...	07/08/2008
7375189	Liver regeneration promoting agent Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages an...	05/20/2008
7371760	Medicinal compositions containing aspirin A combination of 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, which possess excellent inhibitory activity against platelet aggregation and thrombogenesis, and ...	05/13/2008
7365067	Indanol derivative The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein, R1, R2: optionally s...	04/29/2008
7307096	Combined agents for treatment of glaucoma A pharmaceutical composition for the prophylaxis or treatment of glaucoma which comprises an angiotensin II antagonist and at least one compound selected from an adrenaline receptor blocker, a prostaglandin and a carbonic anhydrase inhibitor; and a method for the pr...	12/11/2007
7230023	Water-soluble triazole fungicide A triazole compound of the formula (I) or a pharmacologically salt thereof: wherein X represents a group of formula X—OH which has antifungal activity, L represents an -(adjacently substituted C6-C	06/12/2007
7217805	Bicyclonucleoside analogues Bicyclonucleoside analogues which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogues which have anti-sense or anti-gene activity as well as in vivo stability. Compounds of the following formula (1) or their pharmaceutically acceptable ...	05/15/2007
7199139	Medicinal compositions containing diuretic and insulin resistance-improving agent The present invention relates to a pharmaceutical composition comprising an insulin sensitizer and a diuretic which can prevent or treat side effects such as edema, cardiac enlargement, body fluid retension or hydrothorax caused by administration of an insulin sensi...	04/03/2007
7199150	Amino alcohol compounds Amino alcohol compounds and phosphonic acid compounds having excellent immunosuppressive activity, pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof, and pharmaceutical compositions comprising such compounds, the compounds ha...	04/03/2007
7176323	Process for the production of γ-keto acetals A process for the production of a γ-ketoacetal compound wherein the desired product is obtained by a simple procedure in a high yield as a high purity product. The reaction scheme for the process is as follows: ...	02/13/2007
7157442	Antibacterial compound The present invention relates to a compound of formula (I) (wherein R1 and R2 represent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally substituted, R3 represents a hydrogen ato...	01/02/2007
RE39420	1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses Compounds of formula (I) and (II): [wherein R is hydrogen, halogen or alkyl; R1 is alkyl, amino or substituted amino; R2 is optionally substituted phenyl; R3 is hydrogen, halogen or optionally sub...	12/05/2006
7122666	Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses Compounds having activity against production of an inflammatory cytokine of formula (I)′: A′ is pyrrole; R1′ is phenyl or naphthyl; R2′ is pyridyl or pyrimidinyl; R3′ is...	10/17/2006
7091363	Compounds for the preparation of carbapenem-type antibacterial agents A compound of a formula (1) or a salt thereof wherein R1 represents a methyl group. The compound is useful for the preparation of carbapenem-type antibacterial agents. ...	08/15/2006
7091352	Compounds substituted with bicyclic amino groups Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof: wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R1 is a sub...	08/15/2006
7074756	Liver generation promoter Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages an...	07/11/2006
7056710	Methods for producing ML-236B, a pravastatin precursor, using a host cell transformed with mlcR, a transcription factor Polynucleotides, such as DNA, are provided which accelerate the biosynthesis of a HMG-CoA reductase inhibitor, ML-236B, in an ML-236B producing micro-organism when introduced in the ML-236B producing micro-organism. Pravastatin, which is an HM-CoA reductase inhibito...	06/06/2006
7041660	Crystalline 1-methylcarbapenem derivatives This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I-1), (I-2) or (I-3) The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against vari...	05/09/2006
7037934	Blood lipid ameliorant composition A blood lipid ameliorating composition containing atorvastatin in combination with an agent selected from the group consisting of a riboflavin derivative, a tocopherol compound, an ascorbic acid derivative, pantethine and taurine. ...	05/02/2006
7034150	Processes for the preparation of carbapenem-type antibacterial agents A process for the preparation of a carbapenem antibacterial compound of the following formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of the following formula (1) or a salt thereof, and a process for the preparati...	04/25/2006
7030138	Benzamidine derivatives A compound of a formula (1) and pharmacologically acceptable salts thereof: wherein R1 represents hydrogen, halogen, alkyl or hydroxyl; R2 represents hydrogen or halogen; R3 represents h...	04/18/2006
7012147	Indoline derivative and process for producing the same The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof. ...	03/14/2006

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Assignee: Sankyo Company, Limited