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| Number | Title | Issue Date |
| 4593031 | Method of treating depression This invention relates to a composition and method for potentiating the antidepressant effect of dibenzocycloheptadiene-type antidepressant agents, for example, nortriptyline, in the treatment of depression, especially geriatric depression, by administeri... | 06/03/1986 |
| 4592919 | Souffle compositions Dry souffle compositions having malto/Dextrin and Zanthan gum and wherein the resulting soufflees have an improved foam structure.... | 06/03/1986 |
| 4588715 | Heptenoic acid derivatives Compounds of the formula ##STR1## wherein R1, R2 and R3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR... | 05/13/1986 |
| 4582848 | 2-substituted-3-indolamines and use thereof as anti-diabetics This disclosure relates to substituted indolamines, which exhibit anti-diabetic activity, having the formula: ##STR1## where m is an integer from 1 to 4, x represents hydrogen or --OH R represents Ar or ##STR2## and Ar represents ##STR3## ... | 04/15/1986 |
| 4571428 | 6-Substituted-4-hydroxy-tetrahydropyran-2-ones 6-Substituted-4-hydroxy-tetrahydropyran-2-ones, useful as anti-atherosclerotic agents, are obtainable by the process of the invention. The 6-substituents have a phenyl, naphthyl, tetrahydronaphthyl or indolyl nucleus bound through an ethenyl unit. The inv... | 02/18/1986 |
| 4551288 | Processes for the preparation of liposome drug delivery systems Process and apparatus for the production of medicament containing liposomes, comprising an aliphatic lipid-sterol-water lamellae, wherein a clear, mixed micellar medicament-detergent-aliphatic lipid-sterol sample is applied to a gel filtration column. The... | 11/05/1985 |
| 4544663 | Indolamine derivatives as anti-fertility agents This disclosure relates to the aspermatogenesis activity of (a) compounds of the formula: ##STR1## where m is an integer from 1 to 4 X represents hydrogen or --OH R represents Ar, ##STR2## Ar represents ##STR3## R1 represents hyd... | 10/01/1985 |
| 4536499 | Isoxazolyl indolamines having anti-diabetic activity This disclosure describes novel compounds of the formula ##STR1## where m is 2, 3 or 4 X is hydrogen or hydroxy R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R | 08/20/1985 |
| 4528191 | Disilacyclohexane derivatives in anti-fertility agents This disclosure relates to the aspermatogenesis activity of compounds of the following formula: ##STR1## where R1 and R2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl having 1... | 07/09/1985 |
| 4499279 | Isoxazolyl indolamines This disclosure describes compounds of the formula ##STR1## where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 represents hydroxy, and R3... | 02/12/1985 |
| 4479911 | Process for preparation of microspheres and modification of release rate of core material This invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is mo... | 10/30/1984 |
| 4474971 | (Tetrahydropyran-2-yl)-aldehydes Single enanitiomers of 6-(2-hydrocarbyl-substituted ethenyl)-bearing, 4-hydroxy tetrahydro-2H-pyran-2-ones, e.g., 6-[2-(2-methyl-1-naphthyl)ethenyl]-3,4,5,6-tetrahydro-4ଲ-hydro xy-2H-pyran-2-one (4R,6S) are obtained by a multi-step process whi... | 10/02/1984 |
| 4472313 | Cyclopropanation of olefins The invention provides a method of converting ethylenically unsaturated units of an olefinic substrate to corresponding cyclopropanyl units, comprising treating the olefinic substrate, in an ether medium, with zinc and diiodomethane and a catalytic amount... | 09/18/1984 |
| 4467096 | Isoxazolyl indolamines This disclosure describes compounds of the formula ##STR1## where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 and R3 each independently ... | 08/21/1984 |
| 4460789 | Process for preparing alkoxylates containing primary amine functions The invention relates to a new process for preparing alkoxylates containing primary amine functions comprising reacting a monoalkanolamine or a polyamine compound with a carbonyl compound to form an amide- or carbamate-type condensation product, reacting ... | 07/17/1984 |
| 4456619 | Amides of 2-alkynoic acids and use for inhibiting accumulation of cholesterol ester in arterial walls The compounds are secondary amides of the formula wherein A is alkyl, a mono- or poly-ethylenically unsaturated acyclic hydrocarbon chain, or a hydrocarbon chain having from 1 to 4 cyclopropanyl units thereon; and B is a radical which may be of the phenyl, ben... | 06/26/1984 |
| 4452787 | 1-Substituted tricyclic quinazolinones having biological activity as tranquilizers Tranquilizers are of the formula I: ##STR1## wherein R° is hydrogen, halo of atomic weight of from 18 to 80, i.e. fluoro, chloro or bromo, or alkyl of 1 to 3 carbon atoms, R is hydrogen, halo of atomic weight of from 18 to 80, alkyl of 1 to 4 carbon... | 06/05/1984 |
| 4453001 | Isoxazolyl indolamines as intermediates This disclosure describes compounds of the formula ##STR1## wherein R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, and R2 represents lower alkyl or ##S... | 06/05/1984 |
| 4451448 | 1-Substituted tricyclic quinazolinones useful as tranquilizers Minor tranquilizers preparable by known processes are represented by the following structural formula I: ##STR1## wherein Ro is hydrogen, halo of atomic weight of from 18 to 80, i.e. fluoro, chloro or bromo or alkyl of 1 to 3 carbon atoms,... | 05/29/1984 |
| 4451464 | Trifluoromethyl substituted tricyclic quinazolinones useful as tranquilizers Tranquilizers are of the formula: ##STR1## wherein R° is alkyl of 1 to 8 carbon atoms, and n is 1 or 2.... | 05/29/1984 |
| 4448785 | N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. -[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain un... | 05/15/1984 |
| 4442017 | Additive blends for polymeric materials Additives, such as stabilizers, antioxidants, antistatic agents etc., are intimately blended with an irradiation-responsive substance, such as an optical brightener, and incorporated in a thermoplastic polymeric material which is then subjected to irradia... | 04/10/1984 |
| 4434161 | Sulfur and silicon-containing fatty acid amides Sulfur and silicon-containing amides, e.g. N-5-sila-3-thia-5,5-dimethyl-pentadecanoyl-1-phenyl-2-(4-methylphenyl)-eth ylamine, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the ami... | 02/28/1984 |
| 4432989 | 댚ryl-1H-imidazole-1-ethanols Fungicides of the formula: ##STR1## wherein R° is alkyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl in which the cycloalkyl is of 3 to 6 carbon atoms and the alkyl portion of 1 to 3 carbon atoms, said cycloalkyl and ... | 02/21/1984 |
| 4421752 | Isoxazolyl indolamines as hypoglycemics This disclosure describes compounds of the formula ##STR1## where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 and R3 each independently ... | 12/20/1983 |
| 4420475 | Silicon-bearing amides Compounds of the formula I: ##STR1## wherein each of R1, R2 and R3 is, independently, (a) alkyl having from 1 to 22 carbon atoms; or (b) of the formula ##STR2## in which m is 0, 1 or 2, and each R' and R" is ind... | 12/13/1983 |
| 4419353 | Isoxazolyl indolamines This disclosure describes compounds of the formula ##STR1## where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 represents hydroxy, and R3... | 12/06/1983 |
| 4416876 | Para-amino benzoic and phenylacetic acid derivatives Compounds of the formula ##STR1## in which R1 is a mono-silicon-containing hydrocarbyl radical having up to 35 carbon atoms; each of R2 and R3 is, independently, a hydrogen atom or lower alkyl having from 1 to 3 carbo... | 11/22/1983 |
| 4415560 | 1-Oxa-2,6-disilacyclohexane-4-carboxamides Silicon-containing amides, e.g., N-[1'-phenyl-2'-(4"-methylphenyl)ethyl]-2,2,6,6-tetramethyl-1-oxa-2,6-disi lacyclohexane-4-carboxamide, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents ... | 11/15/1983 |
| 4415568 | Isoxazolyl indolamines for treating diabetes This disclosure describes compounds of the formula ##STR1## wherein R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, and R2 represents lower alkyl or ##S... | 11/15/1983 |
| 4412952 | Process for 3-hydroxy benzodiazepinones Conversion of 3-acyloxy-benzodiazepin-2-ones into corresponding 3-hydroxy benzodiazepin-2-ones is carried out efficiently with potassium hydroxide or potassium alkoxide as catalyst in lower alkanol solvent at a pH of 11-11.5. The final products, which inc... | 11/01/1983 |
| 4397850 | Isoxazolyl indolamines This disclosure describes compounds of the formula ##STR1## where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 represents hydroxy, and R3... | 08/09/1983 |
| 4384975 | Process for preparation of microspheres Microspheres, prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier.... | 05/24/1983 |
| 4384124 | Cyclopropanyl-bearing amides of tryptophane Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed ... | 05/17/1983 |
| 4378369 | Esters of 2,5-anhydro-D-mannitol Agents for lowering glucose levels in blood having the formula: ##STR1## wherein each R, independently, is hydrogen, C1-6 alkylcarbonyl or a group of the formula ##STR2## where R1 is hydrogen, C1-4 alkyl, C1... | 03/29/1983 |
| 4374130 | 4,4'-(Alkanediyl)-bis(2,2,6,6-tetraalkyl -1-oxa-4-aza-2,6-disilacyclohexanes) This disclosure describes compounds of the formula ##STR1## wherein n is 3, 5 or 7, and each R is lower alkyl having 1 to 4 carbon atoms, or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents in particul... | 02/15/1983 |
| 4366145 | Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation A stable ergot alkaloid soft gelatin capsule consisting essentially of a soft gelatin capsule shell and encapsulated therein a liquid center fill solution consisting essentially of a therapeutically effective amount of an ergot alkaloid of the formula ... | 12/28/1982 |
| 4366154 | Tropyl derivatives Tropyl derivatives of the formula: ##STR1## in which R1 is (a) phenyl linked through a direct bond, --O--, ##STR2## (in which m=2 or 3); (b) diphenylmethyl; or (c) 10H-phenothiazin-10-yl; (each of which type may be substituted, or uns... | 12/28/1982 |
| 4361435 | Copper and amine based aquatic herbicides Herbicidal and algaestatic and algaecidal compositions and use thereof comprising copper salts; both soluble acid salts as copper sulfate, chloride, nitrate, acetate, sulfamate, gluconate, citrate, etc. and basic copper salts such as basic copper sulfate,... | 11/30/1982 |
| 4359474 | 1-Phenyl-pyrazole derivatives as glucagon inhibitors The invention discloses certain 1-phenyl-pyrazole derivatives having pharmacological activity in animals and useful as glucagon inhibiting agents. Nearly all of the compounds of this invention are prepared by cyclization of a phenyl hydrazine compound wit... | 11/16/1982 |
