Assignee: Sandoz Pharm. Corp.

Location: E.Hanover, NJ
No. of patents: 34

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Number	Title	Issue Date
5354772	Indole analogs of mevalonolactone and derivatives thereof Compounds of the formula ##STR1## wherein one of R and Ro is ##STR2## and the other is primary or secondary C1-6 alkyl not containing an asymmetric carbon atom, C3-6 cycloalkyl or phenyl-(CH2)m	10/11/1994
5326758	Low dose temazepam This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia....	07/05/1994
5030632	Low dose temazepam This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia....	07/09/1991
5001255	Idene analogs of mevalonolactone and derivatives thereof Compounds of the formula ##STR1## the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprisi...	03/19/1991
4992428	5-aryl-substituted-2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines The invention discloses certain 5-aryl-substituted,2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines useful as PAF receptor antagonists and for treating tumors, pharmaceutical compositions containing said compounds as an active ingredient thereof and ...	02/12/1991
4973704	Pyrrolyl intermediates in the synthesis of pyrrole analogs of mevalonolactone and derivatives thereof Compounds of the formula ##STR1## wherein R1 is C1-6 alkyl not containing an asymmetric carbon atom, C3-7 cycloalkyl or ##STR2## wherein R5, R6 and R7 are as defined below, R	11/27/1990
4939159	Azaindole derivatives useful as cholesterol biosynthesis inhibitors Compounds of the formula I: ##STR1## wherein X is the residue of an unsubstituted 6-membered aromatic ring having 3 carbon atoms and one nitrogen atom; R1 is C1-6 primary alkyl (free of asymmetric carbon atoms), or isopropyl; R	07/03/1990
4933105	Process for preparation of microspheres Microspheres, prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier....	06/12/1990
4927851	Analogs of mevalonolactone and derivatives thereof Compounds of the formula ##STR1## in which Y is ##STR2## X is O or S; Z is --CHOH--CH2 --CHOH--CH2 --COOH, an ester or salt thereof or the lactone thereof; and each of R1 R2 and R3 can be al...	05/22/1990
4892879	1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and tetrahydro-pyridines useful as anxioltic, psychogeriatric, antisepressant and antischiziphrenic agents Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents....	01/09/1990
4876280	Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use Compounds of the formula ##STR1## wherein R1 is hydrogen, C1-3 alkyl, n-butyl, i-butyl or t-butyl, R2 is hydrogen or C1-3 alkyl, R3 is hydrogen or C1-3 alkyl, R4 is hydrogen, C	10/24/1989
4871546	Gastrointestinal protective coating formulations Tablet formulations for the diffusable release of drugs in the gastrointestinal tract, which formulations protect the gastric mucosa from the effects of solid, gastric irritating drugs. The formulation comprises a drug tablet core, coated with a water per...	10/03/1989
4870199	*Processes for the synthesis of diprotected R[R,S]-3,5-dihydroxy-6-oxohexanoate esters* Process for the synthesis of compounds of the formula ##STR1## in R[R,S] enantiomeric form, wherein each P1 is independently an hydroxy group-protecting group, and R2z is C1-4 alkyl, benzyl or allyl, comprising, as a key...	09/26/1989
4868319	Process for the preparation of monoalkylcarbamate group-containing compounds An improved process for preparing monoalkylcarbamate group-containing compounds comprising reacting a hydroxy group-containing compound with an organic halide and an alkali metal cyanate in the conjoint presence of a phase transfer catalyst and a solvent....	09/19/1989
4851427	Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use Compounds of the formula ##STR1## wherein R1 is C1-6 alkyl not containing an asymmetric carbon atom, C3-7 cycloalkyl or ##STR2## wherein R5, R6 and R7 are as defined below, R...	07/25/1989
4847384	Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor An improved process for preparing certain nitrogen-containing mono- and bicyclic ACE inhibitors comprising reacting an ଱-alkyl amino acid with a disulfide compound to form a thioester intermediate, which intermediate is then amidated with a mono- or...	07/11/1989
4845129	Diaryl substituted cyclopentane and cyclopentene derivatives The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibi...	07/04/1989
4841071	6-substituted-4-hydroxy-tetrahydropyran-2-ones 6-Substituted-4-hydroxy-tetrahydropyran-2-ones, useful as anti-atherosclerotic agents, are obtainable by the process of the invention. The 6-substituents have a phenyl, naphthyl, tetrahydronaphthyl or indolyl nucleus bound through an ethenyl unit. The inv...	06/20/1989
4829081	Analogs of mevalonolactone and derivatives thereof Compounds of the formula ##STR1## in which Y is ##STR2## X is O or S; Z is --CHOH--CH2 --CHOH--CH2 --COOH, an ester or salt thereof or the lactone thereof; and each of R1, R2 and R3 can be a...	05/09/1989
4824950	Chiral stationary phases and columns for chromatographic resolution This invention relates to chiral compositions....	04/25/1989
4822799	Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals Compounds of the formula ##STR1## and processes for and intermediates in the synthesis thereof, pharmaceutical compositions comprising such a compound and the use of such compounds for inhibiting cholesterol biosynthesis and lowering the blood c...	04/18/1989
4820718	N-alkyl-(2- or 5-substituted-2-methoxycarbonyl aminoalkyl furanyl)-substituted cyclimmonium salts and use thereof in PAF inhibition The invention discloses certain N-alkyl-(2- or 5-substituted-2-methoxycarbonyl aminoalkyl furanyl)-substituted cyclimmonium salts useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method ...	04/11/1989
4808607	Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol...	02/28/1989
4804679	Erythro-(E)-7-(3'-C1-3alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl )-3,5-dihydroxyhept-6-enoic acids and derivatives thereof Compounds of the formula ##STR1## wherein R1 is C1-3 alkyl, and Z is ##STR2## wherein R7 is hydrogen, R8 or M, wherein R8 is a physiologically acceptable and hydrolyzable ester group, and M is a ...	02/14/1989
4801457	Polyacetal hydrogels formed from divinyl ethers and polyols A therapeutic composition comprising a therapeutic macromolecular agent incorporated in cross-linked polyacetal....	01/31/1989
4755606	Imidazolyl-3,5-di-(diphenyl-butylsilyloxy) carboxylic acid ester intermediates Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined herein below, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol l...	07/05/1988
4751235	Anti-atherosclerotic indolizine derivatives 7-(indolizin-2-yl)hept-6-enoic acids of the formula I: ##STR1## wherein each of R1 and R2 is, independently, H, alkyl, cycloalkyl, aralkyl or aryl, ##STR2## in which R8 is H, an ester residue or cation; or the la...	06/14/1988
4749696	Hydroxy-[1-substituted carbonyl-2-(or 3-) piperidinyl methoxy]phosphinyloxy]-N,N,N-trialkylalkaneaminium hydroxide inner salt oxides having antitumor activity The invention discloses hydroxy-[1-substituted carbonyl-2-(or 3-) piperidinyl methoxy]phosphinyloxy]-N,N,N-trilkylalkaneaminium hydroxide inner salt oxides useful as antitumor agents, pharmaceutical compositions containing said compounds as an active ingr...	06/07/1988
4737500	1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and -tetrahydropyridines useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents....	04/12/1988
4716039	Virus insecticide compositions Virus insecticide compositions having good stability and wettability are free-flowing particles prepared by spray-drying techniques and having the virus insecticide encapsulated in a matrix comprising an intimate mixture of a protein and clay....	12/29/1987
4670600	Preparation of substituted amines Amines are substituted, e.g. alkylated, by reacting the unsubstituted amine with a ketone or aldehyde, a borohydride and a rigid acid....	06/02/1987
4668794	Intermediate imidazole acrolein analogs Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol ...	05/26/1987
4625039	4-trisubstituted silyl protected hydroxy-6-oxo-tetrahydropyran-2-yl-aldehyde intermediates 6-trans-indol-2-yl-ethenyl)-4-hydroxy-tetrahydro-2H-pyran-2-ones of formula I are obtained by a multi-step reaction involving the procedure: ##STR1## wherein p1 is trisubstituted silyl protective group, and Z is a 2-indolyl radical which m...	11/25/1986
4619917	Substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts The invention discloses certain substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using suc...	10/28/1986

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Assignee: Sandoz Pharm. Corp.