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Assignee: Salk Institute for Biological Studies


Location: La Jolla, CA
No. of patents: 6

NumberTitleIssue Date
8105581Compositions and methods for inducing neuronal differentiation
The present invention provides compositions and methods for inducing neuronal cell differentiation. ...
01/31/2012
8097422Kir channel modulators
Provided is a three-dimensional structure of an alcohol bound to an alcohol-binding site of an inwardly rectifying potassium (Kir) channel, Kir channel alcohol modulators and methods for identifying Kir channel modulators. ...
01/17/2012
8092992Transcriptional regulation of gene expression by small double-stranded modulatory RNA
The invention provides a method for modulating gene expression by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes, wherein the associati...
01/10/2012
7674455Targeted retrograde gene delivery to motor neurons
Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to th...
03/09/2010
7643226Maximal-aperture reflecting objective
Objectives and other optical assemblies include a reflective surface that is truncated at or near a focus based on a curvature of the reflective surface. A specimen is situated at or near the focus of the reflective surface, so that the reflective surface captures a...
01/05/2010
6974671Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
In accordance with the present invention, it has been discovered that CREB regulates hepatic gluconeogenesis via the co-activator, PGC-1. PGC-1 potentiated glucocorticoid induction of the gene for PEPCK, the rate limiting enzyme in gluconeogenesis, via the glucocort...
12/13/2005
 
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