Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8137978 | Diagnostic method for biomarkers of adverse coronary events A diagnostic method using biomarkers to predict future adverse coronary events is provided. More particularly, the present invention is directed to diagnostic tests for characterizing an individual's risk of developing or having cardiovascular disease. In certain em... | 03/20/2012 |
| 8110655 | Method to promote hair growth and/or delay or treat hair loss by administering a TGF-β antagonist or inhibitor The present invention provides methods for promoting hair growth and/or treating or preventing hair loss (alopecia) by contacting the cells with a TGF-β antagonist or inhibitor either alone or in combination with other alopecia-inhibiting compounds. ... | 02/07/2012 |
| 8048660 | Immobilized enzymes and uses thereof Disclosed are bioanodes comprising a quaternary ammonium treated Nafion® polymer membrane and a dehydrogenase incorporated within the treated Nafion® polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion... | 11/01/2011 |
| 8003337 | Method for detecting lysosomal storage diseases A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood c... | 08/23/2011 |
| 7951545 | Method for detecting lysosomal storage diseases A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood c... | 05/31/2011 |
| 7939313 | Biosensors for detecting macromolecules and other analytes The invention generally provides molecular biosensors. In particular, the invention provides molecular biosensors having one or more aptamers. The molecular biosensors are useful in several methods including in the identification and quantification of target molecul... | 05/10/2011 |
| 7871624 | Chimeral polypeptide composition for cross-placenta delivery The invention is directed to chimeral fusion proteins having an IgG1 antibody Fc portion and a lysosomal storage enzyme, particularly a Fc-GUS fusion protein useful in treating Sly's disease in an embryo or fetus. The invention is also directed to methods of treatin... | 01/18/2011 |
| 7863238 | Proteins with an attached short peptide of acidic amino acids Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a meth... | 01/04/2011 |
| 7811809 | Molecular biosensors for use in competition assays The invention generally provides molecular biosensors. The molecular biosensors are useful in competition assays to detect the presence of a target molecule. ... | 10/12/2010 |
| 7795009 | Three-component biosensors for detecting macromolecules and other analytes The invention generally provides three-component molecular biosensors. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules. ... | 09/14/2010 |
| 7674629 | Method for improving chemiluminescent signal The present invention is directed to compositions and methods for improving a chemiluminescent signal. In particular, a reaction buffer with an alkaline pH range of about 9 to 10 provides a maximal chemiluminescent intensity and longevity of luminol that is catalyze... | 03/09/2010 |
| 7638228 | Enzyme immobilization for use in biofuel cells and sensors Disclosed are bioanodes comprising a quaternary ammonium treated Nafion® polymer membrane and a dehydrogenase incorporated within the treated Nafion® polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion... | 12/29/2009 |
| 7608255 | Replication-competent anti-cancer vectors Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and ... | 10/27/2009 |
| 7589069 | Replication-competent anti-cancer vectors Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and ... | 09/15/2009 |
| 7576192 | Rapid and sensitive assay for the detection and quantification of coregulators of nucleic acid binding factors Biosensors and methods to determine the activity of any and all nucleic acid binding factors, proteins, cellular events, nucleic acid binding protein coregulators, or fragments thereof, based upon the stabilization of the interaction of two nucleic acid components, ... | 08/18/2009 |
| 7395789 | Cylindrical engine The invention is directed to an improved internal combustion engine, having a symmetric cylindrical arrangement and using a bevel gear train to join multiple crankshaft sections. It provides for a naturally smoother operation with less vibration than in-line engines... | 07/08/2008 |
| 7232893 | Method of manufacturing a stellate cell death factor The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocyt... | 06/19/2007 |
| 7172865 | Rapid and sensitive assay for the detection and quantification of coregulators of nucleic acid binding factors Biosensors and methods to determine the activity of any and all nucleic acid binding factors, proteins, cellular events, nucleic acid binding protein coregulators, or fragments thereof, based upon the stabilization of the interaction of two nucleic acid components, ... | 02/06/2007 |
| 7109170 | Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor Novel polypeptides or derivatives comprising the factor VIIIa binding site on factor IXa are disclosed. The novel polypeptides or derivatives have anti-coagulation activity. Nucleic acids encoding those polypeptides are also disclosed. Methods for identifying an age... | 09/19/2006 |
| 6978166 | System for use in displaying images of a body part A system for use during a medical or surgical procedure on a body. The system generates a display representing the position of two or more body elements during the procedure based on a reference image data set generated by a scanner. The system produces a reference ... | 12/20/2005 |
| 6881402 | Inhibiting apoptosis with adenovirus RID protein A method for inhibiting apoptosis of a cell expressing a death receptor of the TNFR family is disclosed. The method involves treating the cell with a Receptor Internalization and Degradation (RID) protein complex containing RIDα (10.4K) and RIDβ (14.5K) proteins e... | 04/19/2005 |
| 6716964 | CtIP, a novel protein that interacts with CtBP and uses therefor A novel human protein, CtIP, that interacts with the human cellular protein CtBP, and the nucleotide sequence encoding CtIP are provided. CtIP is useful in diagnostic methods for determining malignancy of cells and in methods for inhibiting neoplasia in patients. Us... | 04/06/2004 |
