Assignee: Rosetta Inpharmatics, Inc.

Location: Kirkland, WA
No. of patents: 21

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Number	Title	Issue Date
6518035	Targeted methods of drug screening using co-culture methods The present invention provides methods of screening for a molecule that inhibits the expression or activity of a protein encoded by a target gene which affects the fitness of a cell. The methods are based on a co-culture assay, and entail culturing togeth...	02/11/2003
6468476	Methods for using-co-regulated genesets to enhance detection and classification of gene expression patterns The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes wit...	10/22/2002
6453241	Method and system for analyzing biological response signal data A system, method, and computer program product for enhanced computer-aided analysis of biological response data is disclosed. In a preferred embodiment, biological datasets are graphically selected by a user from a first active biological viewer window on...	09/17/2002
6370478	Methods for drug interaction prediction using biological response profiles This invention provides methods for detecting and predicting drug interaction. In one embodiment of the invention, a plurality of cellular constituents in a biological sample is monitored as the sample is subject to various drug treatments. The response o...	04/09/2002
6352853	Multi-channel electrode arrays This invention features high-density electrode arrays for use in electroporation. These arrays contain a plurality of electrode pairs where the electrodes in each electrode pair are flat and parallel to each other....	03/05/2002
6351712	Statistical combining of cell expression profiles A method for fluorophore bias removal in microarray experiments in which the fluorophores used in microarray experiment pairs are reversed. Further, a method for calculating the individual errors associated with each measurement made in nominally repeated...	02/26/2002
6324479	Methods of determining protein activity levels using gene expression profiles The present invention provides methods for determining the level of protein activity in a cell by: (i) measuring abundances of cellular constituents in a cell in which the activity of a specific protein is to be determined so that a diagnostic profile is ...	11/27/2001
6303291	Methods for comparing a number of primary targets for two or more drug compositions This invention relates to methods and systems for characterizing the actions of drugs in cells. In particular, the invention provides methods for identifying multiple primary targets through which a drug, drug candidate, or other compound of interest acts...	10/16/2001
6300078	Computer system and method for determining a number of primary targets of a drug This invention relates to methods and systems for characterizing the actions of drugs in cells. In particular, the invention provides methods for identifying multiple primary targets through which a drug, drug candidate, or other compound of interest acts...	10/09/2001
6271002	RNA amplification method The present invention relates to methods and kits for amplification of mRNA using a primer in PCR that contains an RNA polymerase promoter. The invention provides methods for amplification and detection of RNA derived from a population of cells, preferabl...	08/07/2001
6232068	Monitoring of gene expression by detecting hybridization to nucleic acid arrays using anti-heteronucleic acid antibodies The present invention relates to anti-heteronucleic acid antibodies and their uses for detection of RNA-DNA duplexes on arrays. The invention provides a method for detection of total cellular RNA hybridization on microarrays, thus obviating the need for i...	05/15/2001
6222093	Methods for determining therapeutic index from gene expression profiles This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality ...	04/24/2001
6221597	Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticid...	04/24/2001
6218122	Methods of monitoring disease states and therapies using gene expression profiles The present invention provides methods for monitoring disease states in a subject, as well as methods for monitoring the levels of effect of therapies upon a subject having one or more disease states. The methods involve: (i) measuring abundances of cellu...	04/17/2001
6203987	Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes wit...	03/20/2001
6200803	Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticid...	03/13/2001
6197517	Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticid...	03/06/2001
6171794	Methods for determining cross-hybridization The present invention provides methods for distinguishing the fractions of polynucleotide sequences which hybridize to any given probe, including probes on microarrays such as those described herein. In particular, the present invention enables users to i...	01/09/2001
6146830	Method for determining the presence of a number of primary targets of a drug This invention relates to methods and systems for characterizing the actions of drugs in cells. In particular, the invention provides methods for determining the presence of a number of primary targets through which a drug, drug candidate, or other compou...	11/14/2000
6132969	Methods for testing biological network models The present invention provides methods and systems for testing and confirming how well a network model represents a biological pathway in a biological system. The network model comprises a network of logical operators relating input cellular constituents ...	10/17/2000
5965352	Methods for identifying pathways of drug action The present invention provides methods for identifying and representing the biological pathways of drug action on a cell by: (i) measuring responses of cellular constituents to graded exposures of the cell to a drug of interest; (ii) measuring the respons...	10/12/1999

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Assignee: Rosetta Inpharmatics, Inc.