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Assignee: Roche Diagnostics Corporation


Location: Indianapolis, IN
No. of patents: 127

1        
NumberTitleIssue Date
7785338Lancing aid comprising a lancet system that is protected against re-use
The present invention is generally directed towards the field of lancing aids in which disposable lancet systems are used. The lancet system according to the invention has a needle body which surrounds the needle tip in a lancet system in a protective manner and als...
08/31/2010
7682430Device for extracting gas or liquid from microfluidid through-flow systems
The invention concerns a device which is used to separate gas or liquid from microfluidic flow-through systems. The gas or liquid separation is achieved independently of the spatial orientation of the device. In addition the invention concerns a microfluidic flow-th...
03/23/2010
7659074Diagnosis and treatment of disorders of iron metabolism
The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The differential diagnosis can be used to classify disorders of iron met...
02/09/2010
7601684Diagnosis and treatment of disorders of iron metabolism
The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The differential diagnosis can be used to classify disorders of iron met...
10/13/2009
7459526Method for synthesizing peptides, peptide mimetics and proteins
The method for producing peptides, peptide mimetics and proteins is characterized in that an enzyme is used as a biocatalyst together with a peptide mimetic. The native specificity of the enzyme is modified by chemical or genetic manipulation, the substrate mimetic ...
12/02/2008
7407627Analyzer having a rotatable sample rack carrier
The present invention is directed to an automatic chemical analytical apparatus for analyzing liquid samples. In order to provide a fully automatic transport of sample tubes containing samples to be analyzed, the apparatus includes a sample processing unit, a sample...
08/05/2008
7326350System for separating magnetically attractable particles
A system for the separation of magnetically attractable microparticles which are suspended in a liquid, which includes a magnet arrangement having at least two magnets in ring form, the magnet axis of which is oriented perpendicular to the ring plane, and the magnet...
02/05/2008
7291724Oligonucleotides for rapidly identifying microbial DNA or RNA
An oligonucoeotide selected from the group consisting of ISN2 (SEQ ID NO: 43), ISN2* (SEQ ID NO: 44), ISN (SEQ ID NO: 34), ISP2 (SEQ ID NO: 46), ISP2* (SEQ ID NO: 45) and ISP (SEQ ID NO: 33). ...
11/06/2007
7244575Soluble complex comprising a retroviral surface glycoprotein
The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein-(or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially i...
07/17/2007
7241628Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a control zone. The present invention additionally provides new conjugates ...
07/10/2007
7241418Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a control zone. The present invention additionally provides new conjugates ...
07/10/2007
7186384Sample entry device for delivering medical samples to an analyzer
The invention relates to a sample entry device for delivering medical samples, preferably blood samples, from diverse sample containers to an analyzer, wherein sample transfer between sample intake and measuring cells of the analyzer taking place via gas-tight sampl...
03/06/2007
7169555Method for indentifying microbial DNA or RNA
The invention relates to a method for quickly detecting bacterial DNA. The sample containing bacterial DNA is provided and treated according to a PCR method. The DNA copies which are multiplied by means of PCR are detected. ...
01/30/2007
7125519Actuator coupling system and a pipetting module comprising such a coupling system
The present invention is directed a system for coupling a macroactuator to a movable element of a micromachined device. The system includes a micromachined device, a first body for holding a macroactuator, a macroactuator mechanically mounted on the first body, a se...
10/24/2006
7118867Quantitative multiplex PCR with high dynamic range
The invention provides a method for quantitative multiplex PCR of two targets whereby one target is present in at least 100-fold molar excess over that of the other target. The method further comprises the addition of a thermostable DNA polymerase with a final conce...
10/10/2006
7094757Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them
The present invention relates to the diagnosis of transmissible spongiform encephalopathies (TSEs). It especially teaches the production of a soluble prion protein (PrP)-chaperone complex and the advantageous use of such chaperone-PrP complex, especially in the dete...
08/22/2006
7094884Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them
The present invention relates to the diagnosis of Alzheimer's Disease. It especially teaches the production of a soluble Aβ-chaperone complex and the advantageous use of such chaperone-Aβ complex, especially in the detection of Aβ in an immunoassay, as well as it...
08/22/2006
7045054Small volume biosensor for continuous analyte monitoring
Sensors (10, 110, 210, 310, 410) and a method for detecting an analyte are described. Sensors (10, 110, 210, 310, 410) each have a volume of a hydrophilic medium (24) that retains an amount of analyte proportionate to the concentration of analyt...
05/16/2006
6998246Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a control zone. The present invention additionally provides new conjugates ...
02/14/2006
6962982Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them
The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially ...
11/08/2005
6911621Biosensor
A method of forming a biosensor is provided. The method includes providing a substrate and a cover including first and second surfaces, positioning a reagent on the substrate, carving a channel by laser ablation in the first surface, and coupling the first surface o...
06/28/2005
6882425Method and apparatus for examining fluids of biological origin
A quality test of fluids of biological origin can be performed optically with applying a suitable evaluation method. In case of two components to be determined in a such fluid, an extinction spectrum is approximated in a first wavelength range by a combination of a ...
04/19/2005
6872315Pump for low flow rates
The present invention concerns a method of producing flow rates of a transport liquid of about 1 to 1000 nl/min. The method provides a pump having a housing defining a space and including a channel and a wettable membrane positioned in the housing, the membrane incl...
03/29/2005
6866758Biosensor
A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support, each electrode including a meter-contact portion and a measurement portion, and a sensor support ...
03/15/2005
6860993Pump for low flow rates
The present invention concerns a pump for flow rates from about 1 to 1000 nl/min in which liquid transport takes place by evaporation of a transport liquid through a wettable membrane. The pumps according to the invention are particularly suitable for applications i...
03/01/2005
6833111Multiple analyte assaying device with a multiple sample introduction system
A multiple analyte assaying device includes a casing having a pocket portion adapted to capture or contain a predetermined volume of fluid specimen to be assayed. Disposed within the casing is a sample receiving pad and one or more reagent test strips. The pocket po...
12/21/2004
6828158Microparticle enhanced light scattering agglutination assay
Reagents and the use of the reagents in a microparticle light scattering agglutination assay are disclosed. The reagents comprise a mixture of particles having relatively stronger light scattering properties and particles having relatively weak light scattering prop...
12/07/2004
6814843Biosensor
A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a top side and a generally flat bottom side. The bottom side is coupled to the substrate to define a sealed portion and an unsealed portion. The unsealed...
11/09/2004
6814844Biosensor with code pattern
The present invention relates to a biosensor. The biosensor includes a support substate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast be...
11/09/2004
6794496Immunoassay for LSD and 2-oxo-3-hydroxy-LSD
The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indo...
09/21/2004
6787109Test element analysis system
Analysis system for the analytical investigation of a sample, in particular of a body fluid. It consists of test elements brought into contact, for performing an analysis, with a sample to be investigated, and an evaluation apparatus with a test element support for ...
09/07/2004
6780296Thermally conductive sensor
A sensor strip comprises an electrode substrate, an electrode set, on the electrode substrate, and a heat conducting layer, on the electrode substrate opposite the electrode set. A sensor instrument for use with this sensor strip comprises a temperature sensor, at a...
08/24/2004
6767440Biosensor
A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support substrate, a sensor support substrate coupled to the electrode support substrate, and electrically...
07/27/2004
D493536Glucose meter
07/27/2004
6755949Biosensor
A biosensor is provided in accordance with the present invention. The biosensor includes a substrate and a cover extending across at least a portion of the substrate. The cover includes a first surface facing the substrate and a second surface. At least a portion of...
06/29/2004
6730488Immunological materials and methods for detecting dihydropyrimidine dehydrogenase
Monoclonal antibodies against dihydropyrimidine dehydrogenase are disclosed. Immunologic assays using the monoclonal antibodies are also disclosed. ...
05/04/2004
D487594Container for a test strip drum
03/16/2004
6703196General purpose structure of an analytical element and its application for analyte determination
The invention concerns an analytical element for the determination of an analyte containing in or on material which enables liquid transport between zones, a sample application zone and a detection zone located downstream thereof, wherein the detection zo...
03/09/2004
6699718Method, reagent and test cartridge for determining clotting time
The invention is a method, reagent and test cartridge for the determination of the clotting time of a blood sample by means of a reagent containing tissue factor and a sulfatide. In an alternative embodiment, the reagent may contain tissue factor and at l...
03/02/2004
6682704Magazine for storing test elements
The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite t...
01/27/2004
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