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Patent No. 5285430

Behavior Modification Wristwatch

A wristwatch including a watch band and a watch body having an octagon shaped perimeter and being red in color and having the word STOP thereon to resemble a stop sign.

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Assignee: Rhone-Poulenc Sante


Location: Antony, FR
No. of patents: 64

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NumberTitleIssue Date
5426117N-methyl-2-(3-pyridyl)-tetrahydrothio-pyran-2-carbothioamide 1-oxide to the preparation of medicinal products intended for treatment of coronary insufficiency
Application of N-Methyl-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxide, in the form of a racemic mixture of the 1S,2S and 1R,2R isomers or in the form of the 1R,2R isomer, to the preparation of a medicinal product intended for the treatment of ...
06/20/1995
5298248Method for continuous liberation of active constituents into water
An apparatus is provided for continuous and regular liberation of active constituents into domestic water supplies. The apparatus comprises a receptacle having a body portion which is impermeable to water and to the active constituent. The receptacle is p...
03/29/1994
5274178Terpene derivatives, their preparation and their use
Terpene derivatives of formula I, their preparation and their use. In formula I, R represents a hydrogen atom or an alkanoyl radical and R' represents a hydrogen atom or an aliphatic hydrocarbon radical. ##STR1##...
12/28/1993
5188841Sustained release pharmaceutical formulations
The invention provides a sustained release formulation of ketoprofen comprising granules each of which comprises a core comprising ketoprofen and microcrystalline cellulose and a coating comprising a water-soluble and a water-insoluble cellulose derivativ...
02/23/1993
5151436Derivatives of thioformamide
Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyrid...
09/29/1992
5137690Process and apparatus for the determination of the iodine content of drinking water
A process and apparatus for the determination of the iodine content of drinking water by comparing the coloration of the water to be analyzed with that of an iodine reference solution in the presence of a fixed amount of cerium and arsenic....
08/11/1992
5130313Serotonin antagonists, their preparation and medications containing them
This invention relates to compounds of formula: ##STR1## in which R1 denotes a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by an optionally substituted phenyl, optionally substituted 3-indolyl or 3-(5-hydroxyindolyl)...
07/14/1992
5130171Process for encapsulating particles with a silicone
Particles of active substance are encapsulated by spraying them with a thermoplastic silicone copolymer in solution in an organic solvent or in an aqueous dispersion or emulsion and removing the solvent or water by drying with hot air. The spraying/drying...
07/14/1992
5124459Process for the preparation of 3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile
3-(3-Pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile is prepared by the action of 2-chloroacrylonitrile on a salt of 3-formyl-2-(3-pyridyl)-4-thiazolidinecarboxylic acid with an organic base in the presence of an acid chloride in an organic solvent c...
06/23/1992
5120852Process for preparing (1R,2R)-2-(3-pyridyl)-tetrahydrothiopyran-2-carbothioamide 1-oxides thereby
Process for preparing (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides of general formula: ##STR1## (R1 =alkyl containing 1 to 4 carbon atoms), by the action of an alkyl isothiocyanate on the 1R,2R and 1R,2S sulphoxi...
06/09/1992
5114949Heterocyclic derivatives, their preparation and medicinal products containing them
Compounds are disclosed of formula: R1 --(CH2)n --Het in which R1 represents a residue of formula ##STR1## X represents a hydrogen atom or an alkyl radical, Y represents a hydrogen atom or an alkyl or alkoxy rad...
05/19/1992
5102667Isoindolone derivatives, their preparation and the pharmaceutical compositions containing them
This invention relates to isoindolone derivatives of general formula (I) in which the radicals R are hydrogen atoms or together form a bond, the symbols R' are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or...
04/07/1992
5102890Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
This invention relates to pyrrole derivatives of formula: ##STR1## in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-[1,4]oxathiino[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H-[1,4]dit...
04/07/1992
5102581Process for the preparation of pseudoionone using oxidative decarboxylation
Process for the preparation of: ##STR1## by oxidative decarboxylation of an allyl ଲ-ketoester: ##STR2## in an organic solvent, in the presence of a palladium-based catalyst. The organic solvent selected from an amide, a nitrile, or a dinit...
04/07/1992
5097064Process for preparing optically active 2-arylpropionic acids
This invention relates to a process for preparing an optically active 2-arylpropionic acid of general formula (I), by the hydrogenation, in a heterogeneous aqueous-organic medium, of a 2-arylacrylic acid of general formula (II) in the presence of a cataly...
03/17/1992
5091388Pyridobenzoindole derivatives, their preparation and compositions which contain them
New pyridobenzoindole derivatives of general formula (I), in which R is H or alkyl (1 or 2 C), alk is straight or branched alkylene (2 to 4 C), R1 denotes a hydrogen atom or an alkyl radical (1 or 2 C), R2 denotes a hydroxy or methox...
02/25/1992
5089405Process for the preparation of optically active 2-arylpropionic acids and pharmaceutical compositions containing the same
S Enantiomers of 2-arylpropionic acids are made by enantioselective hydrolysis of the corresponding racemic 2-arylpropionamides in the presence of a microorganism, or of an enzyme derived therefrom, able selectively to hydrolyze racemic ଱-phenylprop...
02/18/1992
5089527Pentamidine solutions
The invention provides a stabilized aqueous solution of a water soluble pentamidine salt comprising an acetate buffer, and having a total acetate concentration of 0.01-0.06M, and a pH of 4.0-5.0 at room temperature....
02/18/1992
50860511H, 3H-pyrrolo[1,2-c]thiazole-7-carboxamide derivatives and pharmaceutical compositions containing them
New derivatives of formula (I) in which R1 =H, halogen, alkyl, alkyloxy, CF3, NH2, alkylamino, dialkylamino, OH, CH, phenyl or phenoxy, Ar=phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, thienyl, thieno[2,3-b]thienyl or ...
02/04/1992
5077052Chitosan derivatives useful in compositions for coating feedstuff additives intended for ruminants
Novel organosoluble derivatives of chitosan, useful in coating biologically active feedstuff additives intended for ruminants, to provide coatings which are stable at a pH greater than 5 and which release the biologically active substance at a pH below 3....
12/31/1991
5068214Process for the preparation of a catalyst
This invention relates to a process for preparation of a platinum-cobalt bi-metallic catalyst having an alloy structure....
11/26/1991
50682382-alkyliminobenzothiazoline derivatives, processes for preparing them and medicinal products containing them
Compounds of formula: ##STR1## R1 represents a polyfluoroalkoxy radical, R2 represents an alkylthioalkyl, alkylsulphinylalkyl or alkylsulphonylalkyl radical, and R3 represents an alkyl radical, as well as the salts of thes...
11/26/1991
5064843Pyrid-3-yl thioformamide compounds which have useful pharmaceutical utilities
This invention relates to a thioformamide derivative of the formula I ##STR1## wherein: R and R1 each independently represent an alkyl group; A represents either: (1) a phenyl group which is optionally substituted; or (2) a heteroaromatic group (e.g...
11/12/1991
5049669Analgesic phenothiazine derivatives
Phenothiazine derivatives of general formula (I), in which R is a linear or branched (1 to 6 C) alkyl radical and R1 and R2, which may be identical or different, are linear or branched (1 to 4 C) alkyl radicals or form, with the nitr...
09/17/1991
50495745-trifluormethoxy-2-benzimidazolamine compounds
5-Trifluoromethoxy-2-benzimidazolamine and its salts with an inorganic or organic acid, its preparation and medicinal products containing it....
09/17/1991
5036075Derivatives of (AZA) naphthalensultam, their preparation and compositions containing them
This invention relates to a compound of the formula: ##STR1## in which R1 represents a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position. a 1-piperazinyl radical substituted in the 4-position. a piperidino radical substituted in the...
07/30/1991
5034329Process for the preparation of optically active 2-arylalkanoic acids
Optically active 2-arylalkanoic acids are made by enantioselective hydrolysis of the corresponding racemic amides in the presence of a microorganism, or of an enzyme derived therefrom, able selectively to hydrolyse racemic ଱-phenylpropionamide to S ...
07/23/1991
50267172-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharmaceutical compositions containing them
Compounds of formula: ##STR1## and their salts, in which R1 represents polyfluoroalkoxy, and R2 represents alkyl, alkenyl (3-6 C), [cycloalkyl (3-6 C)]-alkyl, carbamoylalkyl, dialkylcarbamoylalkyl, acylaminoalkyl, phenylthioalky...
06/25/1991
5026846Process for the preparation of diaryl sulphides and diaryl selenides
Diaryl sulphides and diaryl selenides of formula: Ar--X--Ar where X=S or Se and Ar=aryl are made by the action of sulphur and sulphur dioxide or selenium and selenium dioxide on a compound of formula: Ar--H The process is especially useful for the preparation of ph...
06/25/1991
5025013Benzopyran derivatives, their preparation and pharmaceutical compositions containing them
New benzopyran derivatives of general formula (I) in which: R1 represents a hydrogen or halogen atom or a hydroxy, alkyloxy, nitro, amino, alkylsulphonamido or acylamino radical, R represents (1) radical ##STR1## R2 and R3
06/18/1991
5023361Process for preparing hydroxyalkylating agents, the agents so obtained, and their use
Hydroxyalkylating agents of formula: ##STR1## in which R denotes alkyl, n is 2 or 3, R1 denotes hydrogen or alkyl and R2 denotes alkyl an unsubstituted or substituted phenyl or ##STR2## are useful inter alia for the prepara...
06/11/1991
5021420Derivatives of (AZA)naphthalenesultam, their preparation and compositions containing them
This invention relates to a compound ##STR1## in which R1 represents a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or a...
06/04/1991
5017576Quinolyloxyacetamides
Quinoline derivatives of formula: ##STR1## in which either R1 denotes trifluoromethyl, R2 and R3 form, together with the nitrogen atom to which they are attached, morpholino and R4 denotes a 4-methylphenyl,...
05/21/1991
5013855Process for the preparation of aromatic ethers
A process for the preparation of an aromatic ether of general formula: ##STR1## by the action of 3-chloro-1,2-propanediol sulfate on a phenol of general formula: Ar--OH in the presence of an inorganic base. Use of a product obtained according to the proce...
05/07/1991
50082802-iminobenzothiazoline derivatives, their preparation and pharmaceutical compositions containing them
Compounds of the formula: ##STR1## in which - R1 denotes a polyfluoroalkoxy or polyfluoroalkyl radical, and - R2 denotes either a chain --CH2 --(CH(R4))n --R3, in which R3 d...
04/16/1991
5006546Imidazole derivatives
The invention provides: (2S,4R,6S)-6-[(4,5-diphenylimidazol-2-yl)thiomethyl]-4-hydroxy-2-methoxy-3 ,4,5,6-tetrahydro-2H-pyran and (2R,4R,6S)-6-[(4,5-diphenylimidazol-2-yl)thiomethyl]-4-hydroxy-2-methoxy-3 ,4,5,6-tetrahydro-2H-pyran or a mixture thereof...
04/09/1991
5003110Process for the preparation of saturated aldehydes by hydrogenation of ଱,ଲ-unsaturated aldehydes
Saturated aldehydes are prepared by hydrogenation of ଱,ଲ-unsaturated aldehydes in a two-phase medium in the presence of a catalyst consisting of a rhodium derivative combined with a water-soluble ligand or of a rhodium complex with a water-sol...
03/26/1991
4994470Benzopyran derivatives and pharmaceutical compositions containing them
New benzopyran derivatives of general formula (I) in which: R1 denotes a hydrogen or halogen atom or a hydroxy, alkyloxy, nitro, amino, alkylsulphonamido, bis(alkylsulphonyl)amino, or acylamino radical, R denotes a radical of general formula: ##STR1...
02/19/1991
49945695,6-dihydro-4H-1,3-oxa(or thia)zine derivatives, their preparation and compositions containing them
Compounds of formula: ##STR1## in which R1 denotes 2-indolyl, 2-thienyl, 3-furyl, naphthyl, phenyl, or phenyl substituted with one or two halogen atoms, with alkoxy, alkyl, nitro, acylamino, alkylthio, acyl, trifluoromethoxy, morpholino, ...
02/19/1991
4990441Process for separating 2-keto-L-gulonic acid from a fermented medium
2-Keto-L-gulonic acid is separated from a fermented medium containing the calcium salt of 2-keto-L-gulonic acid, by carrying out the following operations: separation of insolubles; removal of inorganic cations; and separation of the 2-keto-L-gulonic acid....
02/05/1991
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