Assignee: Rhone-Poulenc Rorer S.A.

Location: Antony, FR
No. of patents: 227

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Number	Title	Issue Date
6312946	Viable contaminant particle free adenoviruses, their prepartion and use Novel adenovirus-derived viral vectors, the preparation thereof, and their use in gene therapy, are disclosed. In particular, recombinant adenoviruses including an adenovirus genome wherein (i) the E1 region is inactivated, (ii) the genomic organization i...	11/06/2001
6300375	Sodium oxamate for the treatment of diabetic conditions The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and consti...	10/09/2001
6294377	Adenoviral vectors of canine origin The present invention resides in use of a recombinant adenovirus of animal origin containing a heterologous DNA sequence for the preparation of a pharmaceutical composition intended for the therapeutic and/or surgical treatment of the human body....	09/25/2001
6287762	Purification of a triple helix formation with an immobilized oligonucleotide Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on s...	09/11/2001
6288075	Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same Compounds of formula (I): ##STR1## their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them are discussed....	09/11/2001
6261807	Method for preparing a recombinant adenovirus genome A novel method for preparing recombinant adenoviruses and the use of such adenoviruses in gene therapy are disclosed. Plasmids used in the construction of said adenoviruses are also disclosed....	07/17/2001
6239270	Nucleic acids encoding human calcium sensor protein The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demon...	05/29/2001
6235497	Recombinant expression of the rat vesicular acetylcholine transporter A nucleic sequence coding for a protein involved in the vesicular transport of acetylcholine, the corresponding protein and the promoter sequences implicated in expressing said protein are disclosed. The invention also discloses expression vectors contain...	05/22/2001
6210963	Recombinant cells from the monocyte-macrophage cell line for gene therapy Cell compositions containing mononuclear phagocyte systems cells, and their use in cell therapy, e.g. adoptive immunotherapy, are disclosed....	04/03/2001
6210879	Method for diagnosing schizophrenia The present invention relates to a method for diagnosing schizophrenia, said method being based on the detection in vitro of the presence of the allele Ep of the microsatellite HUNTH01 in the gene TH. The invention also relates to the primers used for imp...	04/03/2001
6207675	Pyrrole derivatives, their preparation and pharmaceutical compositions containing them The invention concerns pyrrole derivatives of general formula (I) useful for treatment and prevention of diseases in which are involved viruses of the herpes family and/or cytokines in particular TNF଱. ##STR1##...	03/27/2001
6200798	Defective recombinant adenoviruses with inactivated IVa2 gene The present invention relates to new viral vectors derived from adenoviruses, their preparation and utilization in gene therapy. It relates particularly to defective recombinant adenoviruses wherein the Iva2 gene at least is inactivated....	03/13/2001
6197980	4-Acetoxy-2଱-benzoyloxy-5ଲ,20-epoxy-1ଲ,7ଲ,10ଲ-tri hydroxy-9-oxo-11-taxen-13଱-yl(2R,3S)-3-t-butoxycarbonylamino-3-phenyl -2-hydroxypropionate trihydrate 4-acetoxy-2଱-benzoyloxy-5ଲ, 20-epoxy-1ଲ, 7ଲ, 10ଲ-trihydroxy-9-oxo-11-taxen-13଱-y1(2R,3S)-3-t-butoxycarbonyla mino-3-phenyl-2-hydroxypropionate trihydrate obtained by a process of centrifugal partition chromatography....	03/06/2001
6194412	Mixtures derived from grains of Eugenia Jambolana Lamarck preparation and use of said mixtures and some of their constituents as medicaments The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and consti...	02/27/2001
6194582	Taxoids, their preparation and pharmaceutical compositions containing them New taxoids of general formula (I), their preparation, and pharmaceutical compounds containing them. ##STR1## In general formula (I), for example, Ar represents an aryl radical, R represents an alkoxyacetyl radical, R1 represents a benzoyl radical o...	02/27/2001
6187746	Pharmaceutical compositions based on dalfopristine and on quinupristine, and preparation thereof The present invention relates to injectable compositions containing a dalfopristine/quinupristine combination comprising an aqueous solution containing the dalfopristine/quinopristine combination and an additive intended to avoid or reduce the intolerance...	02/13/2001
6180362	Peptides which inhibit ras protein activity, their preparation and use Peptides capable of inhibiting the transforming activity of activated p21 proteins, their preparation and compositions containing them are disclosed. Particular regions of the GAP protein have been identified and characterized that are involved in the tra...	01/30/2001
6160135	Taxoids, preparation thereof and pharmaceutical compositions containing same Novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing same, are disclosed. In general formula (I), Z is a hydrogen atom or a radical of general formula (H), wherein R1 is an optionally substitu...	12/12/2000
6156789	Method for treating abnormal cell proliferation in the brain This invention relates to a method for treating abnormal cell proliferation in the brain by administering a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof: ##STR1## in which R represents a hydrogen atom or an acetyl,...	12/05/2000
6156545	Biosynthesis method enabling the preparation of cobalamins The present invention relates to a biosynthetic process for preparing cobalamines. More precisely, it relates to a process for amplifying the production of cobalamines and, more specifically, of coenzyme B12 by means of recombinant DNA techniqu...	12/05/2000
6150387	Heterocyclic carboxamide compounds effective in the treatment of drug abuse This invention relates to the use of heterocyclic carboxamide compounds for preventing or reducing self-administration, by a human or animal patient, of a drug or a substance capable of giving rise to pharmacomania or to overuse. The preferred types of dr...	11/21/2000
6146663	Stabilized nanoparticles which may be filtered under sterile conditions This invention relates to stabilized nanoparticles which may be filtered under sterile conditions, comprising at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) which is emulsified...	11/14/2000
6143530	Circular DNA expression cassettes for in vivo gene transfer Double-stranded DNA molecules characterised in that they are circular and in that they essentially include one or more genes of interest....	11/07/2000
6143518	Method for the production of recombinant proteins, plasmids and modified cells Expression plasmids comprising a nucleic acid sequence of interest controlled by a T7 bacteriophage promoter and a stabilizing region comprising all or part of the par region of the RP4 plasmid or a derivative thereof. The invention also concerns the use ...	11/07/2000
6140112	Pharmaceutical compositions and their use, namely for the treatment of neurodegenerative diseases The present invention pertains to the use of compounds affecting the activity of transcription factors for the preparation of a pharmaceutical composition for the treatment of neurodegenerative diseases....	10/31/2000
6127175	Cells for the production of recombinant adenoviruses The invention relates to cells usable for the production of defective adenoviruses comprising, inserted into their genome, a portion of the region E4 of an adenovirus genome carrying the reading phase ORF6 under the control of a functional promoter....	10/03/2000
6124465	Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents ...	09/26/2000
6120805	Microspheres, process for their preparation and their use Biocompatible microspheres containing one or more active principals, a biodegradable and biocompatible polymer and a surface-active agent which is also biodegradable and biocompatible, contain less than 10 ppm of heavy metals. These microspheres are prepa...	09/19/2000
6117649	Genetically engineered yeast strains Yeast strains expressing human genes coding regulating cytochrome P450 expression, a method for making same and applications thereof are described....	09/12/2000
6114550	Method for the stereo-selective preparation of a derivative of ଲ-phenyl-isoserine and its use in the preparation of taxane derivatives A ଲ-phenylisoserine derivative of general formula (I): ##STR1## in the form of a salt or an ester, in which Ar represent an aryl radical, R represents a phenyl or naphthyl or a O--R1 radical and G1 represents --CH2	09/05/2000
6107286	Lipopolyamines as transfection agents and pharamaceutical uses thereof Cationic lipids of general formula (I), wherein m is an integer from 2 to 6 inclusive; n is an integer from 1 to 9 inclusive, preferably 1-5, where, when n is 2-9, a single R grouping other than hydrogen is present in the general formula, and m has variab...	08/22/2000
6100264	5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them A compound of the formula ##STR1## in which Ra represents an -alk-COOalk' radical, a --CH2 --PO(Oalk)2 radical, a --CH.dbd.CH--COOalk' radical or a phenyl radical substituted with an alkoxycarbonyl radical....	08/08/2000
6057454	1-oxo-1H-inden-2-yl-1H-imidazole-2-carboxylic acid intermediates A compound of formula (II): ##STR1## in which R is a hydrogen atom or a carboxy, alkoxycarbonyl, --CO--NR4 R5, --PO3 H2 or --CH2 OH radical, and R1 is an -alk-NH2, -alk-NH--...	05/02/2000
6043375	Process for the preparation of an oxazolidinecarboxylic acid which is useful for preparing therapeutically active taxoids A method of preparing a taxoid of formula III by esterifying protected baccatin III or deacetylbaccatin III using an oxazolidinecarboxylic acid, or an acid halide, or an acid anhydride thereof....	03/28/2000
6033885	Integrative recombinant adenoviruses, preparation thereof and therapeutical uses thereof The present invention relates to recombinant adenoviruses having a cassette capable of integrating into the genome of infected cells, their preparation, pharmaceutical compositions containing them, and their use. In particular, the cassette contains at le...	03/07/2000
6028245	Transgenic animals overexpressing MDM2 The present invention relates to transgenic, non-human animals overexpressing a MDM2 gene. These animals model MDM2 over-expression associated with human tumors, display a major phenotype characterized by the severe skin disorder ichthyosis, and are usefu...	02/22/2000
6022985	Process for the preparation of 4-acetoxy-2଱-benzoyloxy-5ଲ, 20-epoxy-1, 7ଲ-10ଲ-trihydroxy-9-oxo-tax-11-en-13଱-yl(2R,3S)-3-tert-b utoxy-carbonYlamino-2-hydroxy-3-phenylpropionate trihydrate Process for the preparation of 4-acetoxy-2଱-benzoyloxy-5ଲ,20-epoxy-1,7ଲ, 10ଲ-trihydroxy-9-oxo-tax-11-en-13଱-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate, characterized in that the 4-...	02/08/2000
6017966	Stabilized pharmaceutical compositions containing dobutamine The present invention concerns stable injectable pharmaceutical compositions comprising dobutamine and ascorbic acid, or a salt thereof, and processes to prepare such compositions....	01/25/2000
6013662	Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents ...	01/11/2000
6013240	Nucleic acid containing composition, preparation and uses of same Compositions containing one or more nucleic acids and cationic polymers, and their use in gene therapy, particularly for in vivo nucleic acid transfer....	01/11/2000

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Assignee: Rhone-Poulenc Rorer S.A.