Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.

Location: Collegeville, PA
No. of patents: 84

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Number	Title	Issue Date
6187548	Methods using human calcium sensor protein, fragments thereof and DNA encoding same The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demon...	02/13/2001
6143508	Device and process for cell capture and recovery Devices, processes and compositions are provided for effective separation of cells from a mixture of cells, where depletion or positive selection may be employed to provide a cellular population of interest. Of particular utility is the separation of cell...	11/07/2000
6127550	Stereospecific preparation of chiral 1-aryl-and 1-heteroaryl-2-substituted ethyl-2-amines This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted et...	10/03/2000
6057369	Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds This invention is directed to compounds of formula I: ##STR1## wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are especia...	05/02/2000
6034093	Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of ...	03/07/2000
5866685	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides The present invention relates to azacycloalkylalkanoyl peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardi...	02/02/1999
5863888	Human Bek Fibroblast growth factor receptor The complete cDNA cloning of two human genes previously designated flg and bek is disclosed. These genes encode for two similar but distinct surface receptors comprised of an extracellular domain with three immunoglobulin-like regions, a single transmembr...	01/26/1999
5861314	Adeno-associated viral (AAV) liposomes and methods related thereto A composition for genetic manipulation which comprises a liposome comprised of lipid material, and adeno-associated viral (AAV) material. Typically, the AAV material is plasmid, and comprises a terminal repeat of the AAV genome. Methods are disclosed for ...	01/19/1999
5861171	Adeno-associated viral (AAV) liposomes and methods related thereto A composition for genetic manipulation which comprises a liposome comprised of lipid material, and adeno-associated viral (AAV) material. Typically, the AAV material is plasmid, and comprises a terminal repeat of the AAV genome. Methods are disclosed for ...	01/19/1999
5849538	DNA encoding human endothelial cell growth factors and plasmids comprising said DNA The present invention is directed to DNA encoding human endothelial cell growth factors, and to plasmids comprising said DNA. In particular, the invention relates to DNA encoding a cleavable signal peptide and an endothelial cell growth factor, wherein re...	12/15/1998
5834441	Adeno-associated viral (AAV) liposomes and methods related thereto A composition for genetic manipulation which comprises a liposome comprised of lipid material, and adeno-associated viral (AAV) material. Typically, the AAV material is plasmid, and comprises a terminal repeat of the AAV genome. Methods are disclosed for ...	11/10/1998
5827826	Compositions of human endothelial cell growth factor The present invention is directed to compositions comprising endothelial cell growth factor, an acceptable carrier and, optionally, an extracellular matrix protein, a glycosaminoglycan or serum albumin. The compositions are useful for wound repair....	10/27/1998
5807686	Pluripotential quiescent stem cell population A cell population which is composed of cells bearing the stem cell marker CD34 and which are small in size and have little granulation are obtained by separating low density mononuclear hematopoietic cells according to size and then selecting for CD34	09/15/1998
5795889	Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from ...	08/18/1998
5780590	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-N-N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl!-(L)-aspartyl!-(L)-ଲ -cyclohexyl-alanine amide, to processes for preparing said stable cryst...	07/14/1998
5780280	Recombinant adeno-associated virus vectors Simplified methods to produce recombinant adeno-associated virus (rAAV) vectors are described. The methods involve the use of chimeric plasmids which incorporate the Epstein Barr nuclear antigen (EBNA) gene, the latent origin of replication of Epstein Bar...	07/14/1998
5736554	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties Compounds of the Formula ##STR1## wherein: K is N or N.fwdarw.O; Q is CH2 or O; T is ##STR2## or R3 O--CH2 ; X is a straight or branched chain alkylene, cycloalkylene or cycloalkenylene group, each of which is op...	04/07/1998
5730713	Removal of selected factors from whole blood or its components This invention provides a composition, device and method for the removal of selected factors, such as cytokines or pharmaceuticals, from a substance such as whole blood or plasma. Advantageously, the invention provides for the treatment or prevention of s...	03/24/1998
5731315	Substituted sulfonic acid n-(aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of ...	03/24/1998
5721237	Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties This invention relates to a method for the selective treatment of cell growth and differentiation characterized by activity of the human epidermal growth factor receptor type 2 (HER2). More specifically, this invention relates to the use of substituted or...	02/24/1998
5714493	Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase This invention relates to the treatment of intimation in a patient suffering from such disorder. More specifically, the invention relates to mono- and/or bicyclic aryl or heteroaryl quinazoline compounds in the treatment of inflammation....	02/03/1998
5710158	Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase This invention relates to the modulation and/or inhibition of cell signaling, cell proliferation, cell inflammatory response, the control of abnormal cell growth and cell reproduction. More specifically, this invention relates to the use of mono- and/or b...	01/20/1998
5710254	Purification of von Willebrand factor by affinity chromatography A method of improving the therapeutic activity of von Willebrand Factor obtained from materials comprising on Willebrand Factor comprising incubating said Factor at a temperature of about 20° C. to about 55° C. for about 1 to about 30 hours, most prefer...	01/20/1998
5677329	Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about...	10/14/1997
5674482	Polymers with alkyl- or heteroalkyl -aryl backbone and pharmaceutical compositions incorporating same A biologically active polymeric compound comprising an alkylaryl or heteroalkylaryl backbone having about 5 to about 50 repeating aromatic ring-containing units and which, according to the computer program marketed as SYBYL.RTM. version 5.2 running on a D...	10/07/1997
5656643	Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from ...	08/12/1997
5656598	Use of fibroblast growth factors to stimulate bone growth The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pa...	08/12/1997
5656655	Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase A method of inhibiting cell proliferation in a patient suffering from such disorder comprising the administration to the patient of a pharmaceutically effective amount of a pharmaceutical composition containing, in admixture with a pharmaceutically accept...	08/12/1997
5652366	DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof This invention relates to di[(1 R)-(-)-camphosulfonic acid) salt of [1S-[1଱,2ଲ,3ଲ,4଱,(S*)]]-4-[7-[[2-(3-chloro-2-thienyl )-1-ethylethyl]amino]3 H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxamide , and a p...	07/29/1997
5648243	Human serum albumin expression construct The present invention provides DNA constructs comprising a promoter DNA sequence and a DNA sequence coding for human serum albumin. In one embodiment the human serum albumin sequence comprises at least one, but not all, of the introns in the naturally occ...	07/15/1997
5646153	Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from ...	07/08/1997
5614496	Use of fibroblast growth factors to stimulate bone growth The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pa...	03/25/1997
5612353	Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibi...	03/18/1997
5605884	Factor VIII formulations in high ionic strength media Stable, highly purified Factor VIII protein formulations are provided in high ionic strength media which comprises: sodium chloride, potassium chloride or mixtures thereof; calcium chloride; and histidine as the buffering agent....	02/25/1997
5596020	Amino bi- and tri-carbocyclic alkane bis-aryl squalene synthase inhibitors This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is f...	01/21/1997
5589377	Recombinant adeno-associated virus vectors Simplified methods to produce recombinant adeno-associated virus (rAAV) vectors are described. The AAV rep and cap genes are combined in a single recombinant adenovirus vector, i.e., a rep/cap adenovirus vector which combines in a single vector all comple...	12/31/1996
5571506	Aromatic oligomeric compounds useful as mimics of bioactive macromolecules This invention relates to aromatic oligomeric compounds useful in the treatment of cardiovascular, bone metabolic, hypolipidaemic, neuronal, gastrointestinal and elastase-mediated connective tissue degradation disorders and disorders which may be treated ...	11/05/1996
5571790	Recombinant human endothelial cell growth factor Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human ori...	11/05/1996
5563128	Phosphonate derivatives of lipophilic amines This invention relates to a class of novel phosphonate derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis aryl cycloalkylamino and azacycloalkyl phosphonates. Compounds of this i...	10/08/1996
5561134	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties Compounds of the Formula ##STR1## wherein: K is N or N.fwdarw.O; Q is CH2 or O; T is ##STR2## or R3 O--CH2 ; X is a straight or branched chain alkylene, cycloalkylene or cycloalkenylene group, each of which is op...	10/01/1996

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Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.