Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8148424 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, h... | 04/03/2012 |
| 8138311 | Modified proteins, designer toxins, and methods of making thereof The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositio... | 03/20/2012 |
| 8084413 | Urocortin-III and uses thereof A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology co... | 12/27/2011 |
| 8067179 | Immunoglobulin libraries Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble antibodies comprising a constant domain. Screening methods that employ genet... | 11/29/2011 |
| 8044025 | Urocortin proteins and uses thereof A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Bot... | 10/25/2011 |
| 8043831 | Therapeutic agents comprising pro-apoptotic proteins The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-induc... | 10/25/2011 |
| 8017754 | Attenuated virus strains and uses thereof Methods and compositions concerning mutant flaviviruses with reduced virulence. In some embodiments the invention concerns nucleotide sequences that encode mutant flaviviral proteins. Viruses comprising mutant NS1 and NS4B genes display reduced virulence are provide... | 09/13/2011 |
| 7985435 | Triterpene compositions and methods for use thereof The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoi... | 07/26/2011 |
| 7869958 | Structure-based modulators of B1 G-protein coupled receptors The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present inve... | 01/11/2011 |
| 7824692 | disulfide bond formation proteins and uses thereof Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are... | 11/02/2010 |
| 7820620 | Cripto antagonism of activin and TGF-b signaling Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the ... | 10/26/2010 |
| 7815905 | Methods of increasing insulin sensitivity or decreasing insulin secretion by administering corticotropin releasing factor receptor-2 inhibitors In some aspects, the invention relates to methods for increasing insulin-sensitivity and/or decreasing insulin secretion in an individual by reducing or inhibiting corticotropin releasing factor 2 (CRFR2) signaling. CRFR2 antagonists may block agonism by one or more... | 10/19/2010 |
| 7807143 | Alpha-MSH therapies for treatment of autoimmune disease Methods and compositions for the enteral treatment of autoimmune disease such a multiple sclerosis with polypeptide therapeutics. Enteral therapeutics comprise monomeric alpha-MSH polypeptides such as ACTH. Therapeutic formulations of the invention may be used to re... | 10/05/2010 |
| 7790153 | Method of treating rheumatoid arthritis using orally administered type one interferons The present invention provides a method of treating auto-immune diseases in an animal comprising the step of orally administering a type one interferon to said animal. Also provided is a method of reducing inflammation associated with an auto-immune disease in an an... | 09/07/2010 |
| 7780974 | Avicin coated stents The invention provides novel compositions and methods related to stents, such as coronary stents, comprising avicins, which are triterpene saponin compositions. In particular aspects of the invention, the avicins have growth-inhibiting properties and/or anti-inflamm... | 08/24/2010 |
| 7759091 | Therapeutic agents comprising pro-apoptotic proteins The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-induc... | 07/20/2010 |
| 7754224 | P153 and p156 antigens for the immunodiagnosis of canine and human ehrlichioses and uses thereof Sequences encoding two immunoreactive glycoproteins were cloned from Ehrlichia canis (p153 gene) and Ehrlichia chaffeensis (p156 gene). These two glycoproteins are species-specific immunoreactive orthologs that are useful as subunit vaccines and... | 07/13/2010 |
| 7754211 | Immunotoxins directed against c-erbB-2(HER-2/neu) related surface antigens Novel immunotoxins and methods of treating neoplastic diseases are provided. More specifically, immunotoxins comprised conjugation of a c-erbB-2 targeting moiety and a cell growth modulator are provided. These immunotoxins specifically and selectively kill tumor cel... | 07/13/2010 |
| 7722880 | Immunoreactive 38-KDA ferric binding protein of and uses thereof The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a polynucleotide therefor. In particular embodiments, the protein i... | 05/25/2010 |
| 7718814 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, h... | 05/18/2010 |
| 7678549 | Polyphenol inhibition of nucleoside diphosphate kinase-B activity and cancer metastasis Aggressive human tumor cells from disparate tissues were found to secrete nucleoside diphosphate kinase-B (NDPK-B) as a phosphoprotein into the extracellular environment. The secreted enzyme was capable of trasphosphorylation activity in the absence of a phosphoryl ... | 03/16/2010 |
| 7674463 | Method of inhibiting angiogenesis by administration of a corticotropin releasing factor receptor 2 agonist The present invention provides transgenic mice deficient in corticotropin releasing factor receptor 2 (CRFR2). Mice deficient for CRFR1 exhibit decreased anxiety-like behavior and a decreased stress response. In contrast, CRFR2 null mutant mice are hypersensitive to... | 03/09/2010 |
| 7670632 | Triterpene compositions and methods for use thereof The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoi... | 03/02/2010 |
| 7638607 | Urocortin proteins and uses thereof A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse CDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Bot... | 12/29/2009 |
| 7629153 | Methods and compositions relating to improved lentiviral vector production systems The present invention provides HIV-derived lentivectors which are multiply modified to create highly safe, efficient, and potent vectors for expressing transgenes for gene therapy. The lentiviral vectors comprise various combinations of an inactive central polypurin... | 12/08/2009 |
| 7608638 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is ox... | 10/27/2009 |
| 7601341 | Vascular endothelial growth factor fusion constructs used to inhibit osteoclastogenesis The 121-amino acid isoform of vascular endothelial growth factor (VEGF121) is linked by a flexible G4S tether to a cytotoxic molecule such as toxin gelonin or granzyme B and expressed as a soluble fusion protein. The VEGF121, fusion protein exh... | 10/13/2009 |
| 7575924 | Methods and compositions relating to improved lentiviral vectors and their applications The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiv... | 08/18/2009 |
| 7575751 | Activin-A mutants Members of the TGF-β superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-β ligands including activins,... | 08/18/2009 |
| 7556816 | 28 kDa outer membrane protein multigene family The 28-kDa outer membrane proteins (P28) of Ehrlichia chaffeensis are encoded by a multigene family consisting of 21 members located in a 23-kb DNA fragment in the genome of E. chaffeensis. Fifteen of these proteins are claimed herein as novel sequence... | 07/07/2009 |
| 7521209 | Insertion of furin protease cleavage sites in membrane proteins and uses thereof Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual membrane-free domain that retains its native conformation. This protocol can be u... | 04/21/2009 |
| 7507794 | Isolated soluble corticotropin releasing factor receptor type 2 (sCRFR2) The present invention is directed to compositions and methods related to soluble G-protein coupled receptors (sGPCR). In ceratin aspects the invention includes compositions and methods related to a soluble corticotropin releasing factor receptor related protein, sCR... | 03/24/2009 |
| 7488865 | Urocortin-deficient mice and uses thereof The present invention provides transgenic mice deficient in urocortin. Urocortin null mutant mice are hypersensitive to stress and display heightened anxiety-like behaviors in the elevated plus maze and open field tests. These mice also demonstrate physiological alt... | 02/10/2009 |
| 7482017 | Flavivirus variants having phenotypic variation and immunogenic compositions thereof The present invention concerns isolated attenuated flaviviruses , such as West Nile viruses, having modifications that provide phenotypic varation, particularly in comparison to a more virulent reference strains. The invention encompasses the isolated viruses and im... | 01/27/2009 |
| 7462646 | Osteoclastogenesis inhibitors and uses thereof The present invention provides a method of reducing or inhibiting osteoclast development induced by the receptor for activation of nuclear factor kappa B ligand (RANKL), comprising the step of contacting said osteoclast, or a precursor of the osteoclast, with a phar... | 12/09/2008 |
| 7459427 | Urocortin-III and uses thereof A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology co... | 12/02/2008 |
| 7455839 | Method of inhibiting the formation of inhibin/betaglycan complexes with an anti-betaglycan antibody Inhibins and activins are protein hormones that reciprocally modulate a diversity of regulatory pathways. Competitive binding experiments revealed that betaglycan, the type III TGF-β receptor, also functions as an inhibin receptor. Betaglycan augments the binding o... | 11/25/2008 |
| 7432081 | disulfide bond formation proteins and uses thereof Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are... | 10/07/2008 |
| 7419783 | Engineering of leader peptides for the secretion of recombinant proteins in bacteria The present invention provides methods of isolating of leader peptides capable of directing export of heterologous proteins from the bacterial cytoplasm. The methods rely on the screening of libraries of putative leader peptides or of leader peptide mutants for sequ... | 09/02/2008 |
| 7371723 | Therapeutic agents comprising pro-apoptotic proteins The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-induc... | 05/13/2008 |
