Assignee: Regents of the University of Michigan

Location: Ann Arbor, MI
No. of patents: 67

Number	Title	Issue Date
8067237	Scaffolds for cell transplantation A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident c...	11/29/2011
8003622	Peptide biosynthesis and pain therapy The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a ...	08/23/2011
7955602	Annexin proteins and autoantibodies as serum markers for cancer The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also pr...	06/07/2011
7896222	Manufacture of shape memory alloy cellular materials and structures by transient-liquid reactive joining This invention discloses a method, using pure niobium as a transient liquid reactive braze material, for fabrication of cellular or honeycomb structures, wire space-frames or other sparse builtup structures or discrete articles using Nitinol (near equiatomic titaniu...	03/01/2011
7759081	Annexin proteins and autoantibodies as serum markers for cancer The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also pr...	07/20/2010
7662599	Nucleic acids and polypeptides involved in the production of cryptophycin The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the inventi...	02/16/2010
7646902	Computerized detection of breast cancer on digital tomosynthesis mammograms A method for using computer-aided diagnosis (CAD) for digital tomosynthesis mammograms (DTM) including retrieving a DTM image file having a plurality of DTM image slices; applying a three-dimensional gradient field analysis to the DTM image file to detect lesion can...	01/12/2010
7615189	Analyte accumulation device A device for accumulation of vapor analytes incorporating nanotubes grown by CVD is described. The devices are used in sensors and as a preconcentrator for a gas chromatograph. ...	11/10/2009
7597237	Rotatable multi-pin apparatus, and process for friction driven stitch welding and structural modification of materials A process is disclosed that creates a high shear rate in a workpiece using a head including a ring-shaped rotatable shoulder, a first pin and a second pin, both pins extending downwardly relative to the shoulder. The process includes coupling the workpiece to a tabl...	10/06/2009
7566558	Nucleic acids and polypeptides involved in the production of cryptophycin The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the inventi...	07/28/2009
7479269	Methods for selectively enriching TH1 and TH2 cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	01/20/2009
7276348	Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat...	10/02/2007
7268148	Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying ...	09/11/2007
7267954	Methods for the detection of variant cayman ataxia nucleic acids The present invention relates to ataxia, in particular to protein and nucleic acids encoding proteins associated with ataxia. The present invention provides assays for the detection of ataxia polymorphisms and mutations associated with disease or disease carrier sta...	09/11/2007
7256277	Nucleotide and protein sequence of mammastatin and methods of use A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express ...	08/14/2007
7253271	BSND nucleic acids and proteins The present invention relates to the BSND (barttin) protein and nucleic acids encoding the BSND protein. The present invention provides assays for the detection of BSND and barttin polymorphisms and mutations associated with disease states. ...	08/07/2007
7244557	Method of screening modulators of Nod1 signaling The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling. ...	07/17/2007
7229814	Nucleic acids and polypeptides involved in the production of cryptophycin The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the inventi...	06/12/2007
7229774	Expression profile of prostate cancer The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer marker...	06/12/2007
7220739	Therapeutic application of pro-apoptotic benzodiazepines Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of the following structures:	05/22/2007
7211654	Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling com...	05/01/2007
7208154	Methods and compositions for the treatment of MHC-associated conditions The present invention relates to methods and compositions for counteracting and reversing disease-causing signaling defects in disorders with underlying signal transduction aberrations, including but not limited to rheumatoid arthritis. ...	04/24/2007
7202045	Detection and treatment of cancers of the lung The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the ...	04/10/2007
7189865	Thiomolybdate analogues and uses thereof The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aber...	03/13/2007
7186712	Compositions and methods relating to novel compounds and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat...	03/06/2007
7175843	Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	02/13/2007
7173010	Orphanin FQ receptor The present invention provides Orphanin FQ receptor nucleic acids and polypeptides and uses thereof. In particular, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention a...	02/06/2007
7147863	UVA (> 360-400) and UVB (300-325) specific sunscreens UVB radiation of about 300-310 nm wavelength and UVA radiation of about 380-390 nm wavelength, each of which exists in solar light, induces MMPs (matrix metalloproteinases) in human skin that degrade the collagen of the dermal matrix. This degradation contributes to...	12/12/2006
7144880	Compositions relating to novel compounds and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat...	12/05/2006
7135611	Compositions and methods for characterizing and regulating Wnt pathways The present invention relates to transgenic animal models for altered Wnt expression. The present invention also provides methods for generating animal models and screening methods for identifying biologically active compounds. ...	11/14/2006
7125866	Therapeutic applications of pro-apoptotic benzodiazepines Benzodiazepinc compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of structures (I) or (II): wherein R1, R2, R3	10/24/2006
7115360	Isolation and use of solid tumor stem cells A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation an...	10/03/2006
7112658	Orphanin FQ receptor polypeptides The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of us...	09/26/2006
7108975	Atlastin The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used f...	09/19/2006
7097972	Method and composition for regulating apoptosis This invention provides non-naturally occurring and isolated naturally occurring nucleic acid molecules which encode proteins designated pro-Yama, p11 Yama and p20 Yama. This invention also provides recombinant polynucleotides coding for these proteins. Also provide...	08/29/2006
7092492	Universal radiologic patient positioning marker The present invention relates to autoradiographic marking devices. In particular, the present invention provides compositions useful for marking X-ray films. ...	08/15/2006
7087582	Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21 The present invention provides a combination including a double-balloon catheter and a nucleic acid encoding the cyclin dependent kinase inhibitor p21. The nucleic acid may also encode HLA-B7, an immunotherapeutic agent, a cytokine or a prodrug converting enzyme.	08/08/2006
7074893	Methods and compositions for the treatment of diseases associated with signal transduction aberrations The present invention relates generally to therapeutic methods and compositions. More particularly, methods and compositions to counteract and reverse disease-causing signaling defects in diseases with underlying signal transduction aberrations, including but not li...	07/11/2006
7069151	Mapping of differential display of proteins The present invention relates to protein separation systems and methods capable of resolving and characterizing large numbers of cellular proteins. In particular, the present invention provides a novel mass mapping system and methods for the differential display of ...	06/27/2006
7060493	Nod2 nucleic acids and proteins The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specif...	06/13/2006

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Assignee: Regents of the University of Michigan