Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 6894052 | Diarylalkylpiperazines active on the lower urinary tract Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are diarylalkylpiperazine derivatives. The methods comprise the administration of the novel compounds of the invention, and other compound... | 05/17/2005 |
| 6486163 | Thienopyranecarboxamide derivatives The invention relates to novel N-(substituted phenyl)-N'-[ω-(5-substituted-7-oxo-7H-thieno[3,2-b]pyran-3-carbonyla mino)alkyl]piperazines their N-oxides and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for... | 11/26/2002 |
| 6440963 | Use of selective COX-2 inhibitors for the treatment of urinary incontinence The treatment of neuromuscular dysfunction of the lower urinary tract by compounds which selectively inhibit the COX-2 isozyme is described. The compounds concerned inhibit the COX-2 isozyme with a potency at least 10-fold, and preferably at least 100-fol... | 08/27/2002 |
| 6399614 | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring The present invention is directed to novel 1-(N-phenylaminoalkyl)piperazine derivatives substituted at the position 2 of the phenyl ring. Pharmaceutical compositions comprising the compounds of the invention also are contemplated. The compounds of the pre... | 06/04/2002 |
| 6387909 | Thienopyranecarboxamide derivatives The invention relates to novel N-(substituted phenyl)-N'-[ω-(5-substituted-7-oxo-7H-thieno[3,2-b]pyran-3-carbonyla mino)alkyl]piperazines their N-oxides and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for... | 05/14/2002 |
| 6365591 | Isoxazolecarboxamide derivatives The invention relates to novel N-(substituted phenyl)-N'-[ω-(3-substituted phenyl-4-isoxazolecarbonylamino)alkyl]piperazines, their N-oxides, and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for alph... | 04/02/2002 |
| 6306861 | Thienopyrancecarboxamide derivatives The invention is directed to compounds of Formula I: ##STR1## wherein R is an aryl, cycloalkyl or polyhaloalkyl group, R1 is chosen from the group consisting of alkyl, alkoxy, polyfluoroalkoxy, hydroxy and trifluoromethanesulfonyloxy; each of R... | 10/23/2001 |
| 6271234 | 1,4-disubstituted piperazines Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are 1,4-disubstituted piperazine derivatives. The methods comprise the administration of the novel compounds of the invention, ... | 08/07/2001 |
| 6071920 | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are aniline derivatives substituted at position 2 of the aniline ring. The methods comprise the administration of the novel com... | 06/06/2000 |
| 5952021 | Stabilized biologically active compounds contained in coated microgranules which can be suspended in alimentary fluids A method to protect biactive compounds and microorganisms from inactivation in the gastric tract as well as in foods. The method involves preparation and coating of a multiplicity of microgranules containing the compounds or microorganisms. The microgranu... | 09/14/1999 |
| 5798362 | Quinazolinyl-amino derivatives having -antagonist activity New qunazolinyl-amino derivatives useful as 댑 -adrenoreceptor blockers are described. These compounds can be used as therapeutic agents for treating afflictions and diseases related to hyperactivity of the -adrenergic system, such... | 08/25/1998 |
| 5756737 | Process for the preparation of 9-(2-hydroxy)-ethoxymethyl-guanine A process for the preparation of acyclovir by alkylation of N2 -formylguanine with 2-oxa-1,4-diacyloxybutane and hydrolysis of the resulting intermediate is described.... | 05/26/1998 |
| 5696139 | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure The present invention provides S-enantiomers of 1,4-dihydropyridines useful for the treatment of heart failure, preparation of compositions thereof and a method for the treatment of hypertension and heart failure comprising administration of these compoun... | 12/09/1997 |
| 5670171 | Liquid-suspension controlled-release pharmaceutical composition Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coats of polymeric hydrophilic and hydrophobic... | 09/23/1997 |
| 5654476 | Process for the preparation of gemfibrozil A process for the preparation of 2,2-dimethyl-5-(2,5-xylyloxy)-valeric acid, which process comprises the reaction of 2,5-dimethylphenol with a compound of formula (II), ##STR1## wherein R is an alkyl, aryl, arylalkyl group and --X is a halogen atom, ... | 08/05/1997 |
| 5605896 | Bicyclic heterocyclic derivatives having 1 adrenergic and 5HT1A activities This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding &... | 02/25/1997 |
| 5527545 | Liquid-suspension controlled-release pharmaceutical composition Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coats of polymeric hydrophilic and hydrophobic... | 06/18/1996 |
| 5510119 | Controlled release therapeutic system for liquid pharmaceutical formulations Disclosed is a controlled release pharmaceutical dosage form, including: (a) microgranules of a pharmaceutical and an excipient; (b) a plurality of polymeric lipidic and wax-like coatings applied to the microgranules, the coated microgranules having dimen... | 04/23/1996 |
| 5474994 | Bicyclic heterocyclic derivatives having 1 -adrenergic and 5HT1A This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding &... | 12/12/1995 |
| 5472704 | Pharmaceutical controlled-release composition with bioadhesive properties A pharmaceutical composition for the controlled release of medicinal drugs, which has the property of adhering to biologic tissues is described. The characteristic features of the composition are a plurality of small-size units capable of ensuring a gradu... | 12/05/1995 |
| 5460828 | Process for the preparation of microgranules suitable for suspension in fluids The object of the invention is a process for the preparation of microgranules to be used in controlled-release liquid pharmaceutical compositions. Operating with high-shear mixer-granulators within clearly established crucial parameter ranges, this proces... | 10/24/1995 |
| 5453518 | Flavone derivatives A compound of the general formula: ##STR1## wherein X represents --CO--, --COO--, --CONH--, --CON(CH3)--, --CH2 NH--, --CH2 N(CH3)--, --CH2 NHCO--, --CH2 N(CH3)CO--, --CH | 09/26/1995 |
| 5405619 | Controlled release therapeutic system for liquid pharmaceutical formulations Disclosed is a controlled release pharmaceutical dosage form, including: (a) microgranules of a pharmaceutical and an excipient; (b) a plurality of polymeric lipidic and wax-like coatings applied to the microgranules, the coated microgranules having dimen... | 04/11/1995 |
| 5403842 | Benzopyran and benzothiopyran derivatives The invention relates to benzopyranone and benzothiopyranone compounds, compositions and methods of use which have adrenergic and serotonergic activity.... | 04/04/1995 |
| 5296236 | Controlled release therapeutic system for a liquid pharmaceutical formulations Disclosed is a controlled release pharmaceutical dosage form, including: (a) microgranules of a pharmaceutical and an excipient; (b) a plurality of polymeric lipidic and wax-like coatings applied to the microgranules, the coated microgranules having dimen... | 03/22/1994 |
| 5165937 | Controlled release tablets containing flavoxate Solid dosage form for the controlled release of flavoxate hydrochloride is described. The dosage form includes a matrix allowing gradual release of the flavoxate hydrochloride contained within it, a suitable binder which limits the dimensions of the finis... | 11/24/1992 |
| 4968832 | Novel asymmetric diesters of 1,4-dihydro-2,-dimethyl-pyridine-3,5-dicarboxylic acid Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## w... | 11/06/1990 |
| 4772621 | Antihypertensive diphenylpropyl aminopropyl ester of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## w... | 09/20/1988 |
| 4705797 | N-(3,3-diphenylpropyl) aminoethyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid, compositions and use Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## ... | 11/10/1987 |
| 4093648 | Therapeutically active benzoic acid derivatives and a process for preparing them Therapeutically active 2- and 3-substituted benzoic acid derivatives having the general formula ##STR1## wherein X is OH, NH2 or an anilino group having the phenyl ring unsubstituted or substituted by chlorine or by a 4-ethoxy group; or ... | 06/06/1978 |
| 3933793 | Therapeutically active 2-aminoalkylthio-3H-1.5-benzodiazepines and process for preparing them Novel derivatives of 3H-1,5-benzodiazepine and of their salts of addition with acids, including their quaternary ammonium salts, having the general formula: ##EQU1## are provided. Such compounds are effective therapeutically against a large spec... | 01/20/1976 |
