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| Number | Title | Issue Date |
| 6425888 | Ocular treatment device A unit container for a treatment fluid comprises a sealed enclosure of which one wall section thereof is formed with at least one opening. The enclosure is pressuriseable to discharge its contents through the opening or openings, which is or are of suffic... | 07/30/2002 |
| 6228894 | Softgel-compatible composition containing retinol A softgel-compatible composition containing retinol comprises retinol-impregnated microparticles. The composition may include an optionally thickened silicone oil, or may include an emulsion comprising a silicone oil. Ascorbic acid may be present as ascor... | 05/08/2001 |
| 6022499 | Method for striping or marbleizing capsules An apparatus and a process useful for producing patterned gelatin ribbons for forming patterned soft gelatin capsules are disclosed. The apparatus and process use multiple spreader boxes to form a wide variety of possible patterns.... | 02/08/2000 |
| 5912011 | Solvent system to be enclosed in capsules To increase the solubility of acidic medicines a high concentration solvent system to be encapsulated comprises a) 10-80% by weight acidic medicine, b) 0.1-1.0 mole hydroxide ions for one mole equivalent of said medicine, and c) 1-20% by weight water. included... | 06/15/1999 |
| 5897874 | Expulsion of material from a delivery device A delivery device for delivering an active substance to a patient at a predetermined time after administration comprises a male hydrogel plug engaged in the neck of a female body. An expandable excipient such as a hydrogel powder or a pharmaceutical disin... | 04/27/1999 |
| 5891470 | Softgel formulation containing retinol A softgel formulation containing retinol comprises a soft gelatin shell and a fill material within that shell containing retinol-impregnated microparticles. The fill material may be an optionally thickened silicone oil, or may be an emulsion comprising a ... | 04/06/1999 |
| 5837287 | Process for preparing solid pharmaceutical dosage forms A process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises forming a solution or a suspension in a solvent of a form of the pharmaceutica... | 11/17/1998 |
| 5827541 | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances Process for preparing an oral rapidly disintegrating dosage form of a hydrophobic pharmaceutically active substance comprising forming a suspension of the hydrophobic pharmaceutically active substance in a solvent containing a pharmaceutically acceptable ... | 10/27/1998 |
| 5817323 | Soft gelatin capsule shell compositions A composition for use in the shell of a comestible capsule comprising Gelatin and a plasticiser such as Glycerol together with a further component which forms a secondary matrix for the plasticiser. The provision of this secondary matrix enables the relat... | 10/06/1998 |
| 5770224 | Capsule construction A controlled release capsule comprises a male plug (2) formed of a water swellable hydrogel which is engaged within a neck portion (4) of a female body (6). The capsule contains a pharmaceutically active material. In contact with an aqueous medium, such a... | 06/23/1998 |
| 5750143 | Controlled release device A controlled release capsule comprises a male plug (2) formed of a water-swellable hydrogel which is engaged with a neck portion (4) of a female body (6). The capsule is intended to deliver two dosages of pharmaceutically active material at different time... | 05/12/1998 |
| 5740660 | Method and apparatus for forming soft gelatin capsules containing particulate material Rotary die apparatus for producing filled gelatin capsules comprises two cylindrical rollers mounted with their longitudinal axes substantially parallel and defining a nip therebetween, with at least one roller having a plurality of recesses on its outer ... | 04/21/1998 |
| 5738875 | Process for preparing solid pharmaceutical dosage forms A process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises forming a solution or a suspension in a solvent of a form of the pharmaceutica... | 04/14/1998 |
| 5735105 | Encapsulation apparatus and process A continuous solvent free gelatin encapsulation apparatus and process includes an oil roll back assembly (20) for applying a controlled amount of a food-approved lubricant to a first side of the gelatin ribbon and an applicator guide bar assembly (40) for... | 04/07/1998 |
| 5729958 | Method for manufacturing freeze dried dosages in a multilaminate blister pack An improved method for manufacturing freeze dried pharmaceutical tablets in blister packs is disclosed. Liquid dosages are introduced into a multilayer laminated blister sheet having an impermeable intermediate layer (14) that is positioned between first ... | 03/24/1998 |
| 5672300 | Method for striping or marbleizing capsules An apparatus and a process useful for producing patterned gelatin ribbons for forming patterned soft gelatin capsules are disclosed. The apparatus and process use multiple spreader boxes to form a wide variety of possible patterns.... | 09/30/1997 |
| 5670159 | Fragrance-containing cosmetic gelatin capsule Fragrances in soft gelatin capsules are disclosed. The desired fragrance is dissolved in a solvent system comprising a volatile solvent, a non-volatile cosolvent, or a combination of a volatile solvent and a non-volatile cosolvent or cosolvents. The resul... | 09/23/1997 |
| 5645856 | Delivery systems for hydrophobic drugs There is provided a carrier for hydrophobic drugs, and pharmaceutical compositions based thereon, which carrier comprises a digestible oil and a pharmaceutically acceptable surfactant component for dispersing the oil in vivo upon administration of the car... | 07/08/1997 |
| 5631023 | Method for making freeze dried drug dosage forms The present invention discloses an improved technique for preparing a rapidly dispersing pharmaceutic tablet of a granular therapeutic agent which has both relatively low solubility and relatively large particle size. Xanthan gum is added to a liquid admi... | 05/20/1997 |
| 5624681 | Tamper evident pharmaceutical dosage form A dosage form for pharmaceuticals, nutrient supplements and food products which is nontoxic and suitable for introduction into mammalian bodies comprising soft elastic gelatin capsule containing a colorless clear liquid carrier and an active ingredient. T... | 04/29/1997 |
| 5614217 | Capsule shell formulation to produce brittle capsules A gelatin capsule that is generally resistant to humidity having a non-hygroscopic plasticizer and an elasticity reducing gelatin extender in the formulation of the gelatin capsule shell. The capsule is capable of being manufactured on conventional rotary... | 03/25/1997 |
| 5587149 | Topical application emulsions The present invention relates in general to products for topical application to the skin, and more particularly to improved stable emulsions for containing water soluble active ingredients, such as Vitamin C, glycolic acid, etc., which may nonetheless be ... | 12/24/1996 |
| 5569466 | Fill compositions for soft elastic gel capsules A dosage unit form comprises a biologically active agent, such as a pharmaceutical, nutritional supplement or diagnostic, dissolved or suspended in a carrier liquid encapsulated in a soft elastic gel capsule. The carrier liquid comprises maltitol syrup as... | 10/29/1996 |
| 5554385 | High amylose starch substituted gelatin capsules A gelatin capsule sheath in which a portion of the gelatin is replaced with a high amylose content starch to provide a dry capsule sheath having 3-60% by weight high amylose starch wherein the amylose content of the starch is at least 50% and preferably 9... | 09/10/1996 |
| 5535885 | Fragrance sample container The invention is a fragrance sample container comprised of a central cosmetic-containing portion substantially surrounded by a peripheral portion having thickened edges. The entire container is preferably made of soft-gelatin. The thickened edges of the p... | 07/16/1996 |
| 5529767 | Printed shaped bodies and sheets containing gelatin This invention is comprised of printed shaped bodies and sheets comprising gelatin or having at least an outer surface comprised of at least 5% gelatin or chemically modified gelatin, the shaped bodies and sheets being printed with ink by an ink jet. In p... | 06/25/1996 |
| 5505961 | Gelatin capsules containing a highly concentrated acetaminophen solution A method is disclosed for increasing the solubility of acetaminophen alone or in combination with antihistamines, antitussives, decongestants, and expectorants to form a clear solution for encapsulation into a softgel. The acetaminophen is solubilized alo... | 04/09/1996 |
| 5484598 | Soft gelatin medicament capsules with gripping construction Knurled surfaces such as raised ribs are provided on the shell of a soft gelatin capsule in order to enhance gripping and manipulation of the capsule. The capsule has a removable tab at one end thereof which may also be provided with a knurled surface. On... | 01/16/1996 |
| 5457895 | Method of identifying freeze-dried dosage forms The invention permits the application of an identifying mark onto a freeze-dried tablet without the need for application of pressure or for printing directly on the tablet. The invention comprises the preparation of a freeze-dried unit that is embossed wi... | 10/17/1995 |
| 5422160 | Softgel capsule with a patterned outer shell surface A softgel having a texture on at least a portion of its surface and a process and apparatus for the manufacture thereof. The process for manufacturing the textured softgel includes forming a flowable gelatin mass, providing a rotary drum having an outer s... | 06/06/1995 |
| 5380534 | Soft gelatin medicament capsules with gripping construction Knurled surfaces such as raised ribs are provided on the shell of a soft gelatin capsule in order to enhance gripping and manipulation of the capsule. The capsule has a removable tab at one end thereof which may also be provided with a knurled surface. On... | 01/10/1995 |
| 5376688 | Enhanced solubility pharmaceutical solutions Pharmaceutically acceptable solutions of acidic, basic or amphoteric pharmaceutical agents are disclosed. These solutions are suitable for encapsulation in gelatin capsules for subsequent oral administration and include the pharmaceutical agent, an ion sp... | 12/27/1994 |
| 5358118 | Stepped edge blister pack A stepped-edge blister pack for containing and dispensing unit doses of medication such as capsules, tablets, caplets or fast-dissolving dosage forms (FDDF) is disclosed. The invention is comprised of a base sheet and a substantially planar lidding sheet.... | 10/25/1994 |
| 5246635 | Method and apparatus for the manufacture of textured softgels A softgel having a texture on at least a portion of its surface and a process and apparatus for the manufacture thereof. The process for manufacturing the textured softgel includes forming a flowable gelatin mass, providing a rotary drum having an outer s... | 09/21/1993 |
| 5071643 | Solvent system enhancing the solubility of pharmaceuticals for encapsulation This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises... | 12/10/1991 |
| 5046618 | Child-resistant blister pack A child-resistant blister pack for fragile single-dosage forms, e.g. a fast-dissolving dosage form ((FDDF) is disclosed. Limited entry points are provided, and completion of a sequence of steps is necessary to access the dosage forms within the depression... | 09/10/1991 |
| 4910021 | Targeted enternal delivery system A capsule for oral administration of a pharmaceutically active ingredient contains a pharmaceutical composition comprising the active ingredient, for example, a peptide, an absorption promoter and usually, a carrier. The absorption promoter is capable of ... | 03/20/1990 |
| 4888239 | Ethanol fill formulation for sofgels etc. Gelatin capsules of the type having an outer shell comprising gelatin and, optionally, a plasticizer, and a capsule filling, the filling containing at least one active substance and/or a dietetic agent or foodstuff as well as a solvent mixture, the solven... | 12/19/1989 |
| 4829057 | Oxytetracycline capsules with increased stability and methds of producing the same Soft elastic gelatin capsules containing primarily the crystalline form A of oxytetracycline hydrochloride exhibit increased storage ability.... | 05/09/1989 |
| 4800083 | Sustained release method and product A capsule product and method for gradually releasing a medicament for absorption to a body of a warm blooded animal through the gastrointestinal system. The capsule has a fill material which includes a masticatory substance and a medicament that is disper... | 01/24/1989 |
