Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8173442 | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the ... | 05/08/2012 |
| 8163480 | Nucleic acid size detection method The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequenc... | 04/24/2012 |
| 8158931 | Methods for detecting dihydrotestosterone by mass spectrometry Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.... | 04/17/2012 |
| 8153962 | Mass spectrometry assay for congenital adrenal hyperplasia Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortis... | 04/10/2012 |
| 8124345 | Cystic fibrosis transmembrane conductance regulator gene mutations The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containin... | 02/28/2012 |
| 8114613 | Oxidized APOA1 determination by mass spectrometry Methods are provided for the detection and quantitation of proteins generally and apolipoprotein A-I and oxidized derivatives thereof in particular. Further provided are methods for the assessment of the risk cardiovascular disease in a subject, wherein the assessme... | 02/14/2012 |
| 8106351 | Mass spectrometry assay for plasma-renin Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1... | 01/31/2012 |
| 8101427 | Methods for detecting vitamin D metabolites by mass spectrometry Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount... | 01/24/2012 |
| 8093063 | Assay for detecting genetic abnormalities in genomic nucleic acids The present invention provides methods of detecting unamplifed genomic nucleic acid anchored to a solid support. The methods are useful for the detecting genetic abnormalities associated with various diseases, diagnosis, and prognosis. ... | 01/10/2012 |
| 8093003 | Fluorescence energy transfer by competitive hybridization A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which hav... | 01/10/2012 |
| 8092996 | Method for detecting cystic fibrosis The present invention relates to methods for amplifying various regions of the cystic fibrosis transmembrane regulator (CFTR) gene. Methods are provided for amplifying one or all 27 exons of the CFTR gene and a portion of the CFTR promoter region in a single tube. T... | 01/10/2012 |
| 8084269 | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the ... | 12/27/2011 |
| 8084212 | Assay for nucleic acid Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the IS1245 gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplifica... | 12/27/2011 |
| 8076157 | Vitamin D metabolite determination utilizing mass spectrometry following derivatization The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. ... | 12/13/2011 |
| 8076078 | Cystic fibrosis gene mutations The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containin... | 12/13/2011 |
| 8076074 | Balanced translocation in comparative hybridization The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy num... | 12/13/2011 |
| 8068993 | Diagnosing inapparent diseases from common clinical tests using Bayesian analysis A system and method of diagnosing diseases from biological data is disclosed. A system for automated disease diagnostics prediction can be generated using a database of clinical test data. The diagnostics prediction can also be used to develop screening tests to scr... | 11/29/2011 |
| 8039794 | Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometr... | 10/18/2011 |
| 8039216 | Methods for detecting nucleic acids using multiple signals Disclosed is are methods for identifying a nucleic acid in a sample. In one example, the method includes: (a) contacting the nucleic acid in the sample with an oligonucleotide that is specific for the nucleic acid in the sample and that is labeled with at least a fi... | 10/18/2011 |
| 8034636 | Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 10/11/2011 |
| 8034627 | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydrorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the... | 10/11/2011 |
| 8030084 | Thyroglobulin quantitation by mass spectrometry Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifyi... | 10/04/2011 |
| 8021888 | Rapid comparative genomic hybridization using acoustic surface waves Disclosed is a method for performing nucleic acid hybridization assays which involve the application of acoustic surface waves. The hybridization assays may be used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or as... | 09/20/2011 |
| 8017403 | Mass spectrometry method for measuring vitamin B6 in body fluid Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography. ... | 09/13/2011 |
| 8017015 | Monolithic column chromatography Provided herein are methods of liquid column chromatography in which preparative chromatography is performed in-line with analytical chromatography. In particular aspects a monolithic preparative column is used to purify an analyte of interest from a mixture of othe... | 09/13/2011 |
| 7993931 | Oxygen-18 labeled organic acids and use in diagnosing metabolic disorders Provided are methods and compositions for quantitatively measuring the amount of an unlabeled organic acid in a sample. Oxygen-18 labeled organic acids are used as internal standards to adjust for the loss of a structurally similar or identical unlabeled organic aci... | 08/09/2011 |
| 7972868 | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry Provided are methods of detecting the presence or amount of a dihydroxyvitamin in D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine t... | 07/05/2011 |
| 7972867 | Methods for detecting vitamin D metabolites by mass spectrometry Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount... | 07/05/2011 |
| 7972794 | Oxidized apoA-I determination by mass spectrometry Methods are provided for the detection and quantitation of proteins generally and apolipoprotein A-I and oxidized derivatives thereof in particular. Further provided are methods for the assessment of the risk cardiovascular disease in a subject, wherein the assessme... | 07/05/2011 |
| 7952068 | Methods for detecting catecholamines by mass spectrometry Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting ... | 05/31/2011 |
| 7952067 | Methods for detecting vitamin C by mass spectrometry Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.... | 05/31/2011 |
| 7897362 | Methods and kits for detecting ITA in a biological sample Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnan... | 03/01/2011 |
| 7893399 | Methods for detecting dehydroepiandrosterone by mass spectrometry Provided are methods for determining the amount of underivatized dehydroepiandrosterone (DHEA) in a sample using mass spectrometry. The methods generally involve ionizing DHEA in a sample and detecting and quantifying the amount of the ion to determine the amount of... | 02/22/2011 |
| 7892743 | Subtractive single label comparative hybridization Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisp... | 02/22/2011 |
| 7888075 | Detection of methicillin-resistant and methicillin-sensitive in biological samples Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA) in a sample. The present invention provides a diagnostic method comprising modification of sequences of S... | 02/15/2011 |
| 7838646 | Cystic fibrosis transmembrane conductance regulator gene mutations The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. The mutations include duplication of exons including duplication of exons 6b through 10. Methods of identifying if an individ... | 11/23/2010 |
| 7834313 | Mass spectrometry assay for plasma-renin Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1... | 11/16/2010 |
| 7824928 | Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 11/02/2010 |
| 7824858 | Assay for nucleic acid Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplificatio... | 11/02/2010 |
| 7820388 | Cystic fibrosis transmembrane conductance regulator gene mutations The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containin... | 10/26/2010 |
