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| Number | Title | Issue Date |
| 8183036 | Luciferase biosensor A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided. ... | 05/22/2012 |
| 8183007 | ADP detection based methods using adenylate cyclase and bioluminescence The disclosure provides compositions and methods to determine or detect ADP or the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and ATP hydrolases such as ATPases, e.g., HSP90, that employ ATP as a subs... | 05/22/2012 |
| 8168405 | Covalent tethering of functional groups to proteins and substrates therefor A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 05/01/2012 |
| 8113425 | RF point of sale and delivery method and system using communication with remote computer and having features to read a large number of RF tags A method and system for providing point-of-sale and point-of-delivery and/or distribution of products in a restricted access unit near the customer. The method and system utilize products equipped with radio frequency tags and reduce the effects of energy sharing, s... | 02/14/2012 |
| 8106052 | Luminescence-based methods and probes for measuring cytochrome P450 activity The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step... | 01/31/2012 |
| 8071328 | Bioluminescent protease assay A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided. ... | 12/06/2011 |
| RE42931 | Covalent tethering of functional groups to proteins A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 11/15/2011 |
| 8039613 | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods A formulation containing guanidine thiocyanate together with acetamide, one or more acetamide derivatives, or a combination of acetamide and one or more acetamide derivatives is used to purify one or more nucleic acids contained in a medium. In particular, a medium ... | 10/18/2011 |
| 8031072 | RFID reader enclosure and man-o-war RFID reader system An apparatus including an enclosure for an RFID reader to be affixed to a storage container; an RFID reader that scans a first storage container using a first antenna and a second storage container using a second antenna; and a networked system of RFID apparatuses i... | 10/04/2011 |
| 8030034 | Nucleic acid purification with a binding matrix The present invention relates to methods, kits, and compositions for generating purified RNA samples and purified DNA samples. In particular, the present invention provides methods for generating a purified RNA or DNA sample from a sample containing both DNA and RNA... | 10/04/2011 |
| 8030017 | Thermostable luciferases and methods of production Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, are disclosed. Methods of producing the luciferases include recursive ... | 10/04/2011 |
| 8025228 | RF point of sale and delivery method and system using communication with remote computer and having features to read a large number of RF tags A method and system for providing point-of-sale and point-of-delivery and/or distribution of products in a restricted access unit near the customer. The method and system utilize products equipped with radio frequency tags and reduce the effects of energy sharing, s... | 09/27/2011 |
| 8008006 | Synthetic nucleic acid molecule compositions and methods of preparation A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell. ... | 08/30/2011 |
| 7967199 | Radio frequency identification method and system of distributing products A method and system for vending products from a defined area, such as a micro-warehouse with a door. The method includes fitting each product with a radio frequency identification tag, positioning the plurality of products in a micro-warehouse, sensing opening and c... | 06/28/2011 |
| 7951550 | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. ... | 05/31/2011 |
| 7942321 | Radio frequency identification method and system of disturbing products A method and system for vending products from a defined area, such as a micro-warehouse with a door. The method includes fitting each product with a radio frequency identification tag, positioning the plurality of products in a micro-warehouse, sensing opening and c... | 05/17/2011 |
| 7935803 | Polynucleotides encoding proteins for covalent tethering to functional groups and substrates A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 05/03/2011 |
| 7906298 | Thermostable luciferase mutant A protein having luciferase activity and at least 60% similarity to luciferase from Photinus pyralis, Luciola mingrelica, Luciola cruciata or Luciola lateralis. Hotaria paroula, Pyrophorus plagiophtalamus, Lampyris noctiluca, Pyrocoelia nayako or Ph... | 03/15/2011 |
| 7906282 | Synthetic nucleic acid molecule compositions and methods of preparation A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell. ... | 03/15/2011 |
| 7902343 | Detection of microsatellite instability and its use in diagnosis of tumors Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits ... | 03/08/2011 |
| 7891549 | Biological sample processing apparatus that selects the personality type of the apparatus A biological sample processing apparatus having a central processing unit, a display in communication with the central processing unit and a selector for selecting a personality type of the apparatus, the selector being in communication with the central processing a... | 02/22/2011 |
| 7888086 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 02/15/2011 |
| 7879540 | Synthetic nucleic acid molecule compositions and methods of preparation A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell. ... | 02/01/2011 |
| 7867726 | Compositions comprising a dehalogenase substrate and a fluorescent label and methods of use A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 01/11/2011 |
| 7791479 | RFID point of sale and delivery method and system A method and system for providing point-of-sale and point-of-delivery and/or distribution of products in a restricted access unit near the customer. The method and system utilize products equipped with radio frequency tags and reduce the effects of energy sharing, s... | 09/07/2010 |
| 7784689 | Radio frequency identification method and system of distributing products A method and system for vending products from a defined area, such as a micro-warehouse with a door. The method includes fitting each product with a radio frequency identification tag, positioning the plurality of products in a micro-warehouse, sensing opening and c... | 08/31/2010 |
| 7749706 | Detection of microsatellite instability and its use in diagnosis of tumors Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits ... | 07/06/2010 |
| 7741067 | Luciferase-based assays A method and kit is provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to... | 06/22/2010 |
| 7735732 | Radio frequency identification method and system of distributing products A method and system for vending products from a defined area, such as a micro-warehouse with a door. The method includes fitting each product with a radio frequency identification tag, positioning the plurality of products in a micro-warehouse, sensing opening and c... | 06/15/2010 |
| 7732128 | Kits for detection of ATP Methods and kits for detecting the presence of ATP, for measuring ATP concentrations, and for detecting viable cells using a composition comprising an ATP-dependent enzyme and one or more ATPase inhibitors. ... | 06/08/2010 |
| 7728118 | Synthetic nucleic acid molecule compositions and methods of preparation A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell. ... | 06/01/2010 |
| 7721947 | Biological sample processing apparatus that selects the personality type of the apparatus A biological sample processing apparatus having a central processing unit, a display in communication with the central processing unit and a selector for selecting a personality type of the apparatus, the selector being in communication with the central processing a... | 05/25/2010 |
| 7710275 | RFID reader enclosure and man-o-war RFID reader system An apparatus including an enclosure for an RFID reader to be affixed to a storage container; an RFID reader that scans a first storage container using a first antenna and a second storage container using a second antenna; and a networked system of RFID apparatuses i... | 05/04/2010 |
| 7700310 | Method for detecting transferase enzymatic activity Methods and kits for detecting transferase activity in a sample by measuring ATP using a composition comprising an ATP-dependent bioluminescence-generating enzyme, a luminogenic molecule and one or more transferase quenching agents. ... | 04/20/2010 |
| 7692022 | Luminescence-based methods and probes for measuring cytochrome P450 activity The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step... | 04/06/2010 |
| 7666987 | Bioluminescent caspase assay compounds A sensitive bioluminescent assay to detect proteases including caspases is provided which employs an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a substrate for a caspase or an aminoluciferin or a carboxy... | 02/23/2010 |
| 7661591 | RF point of sale and delivery method and system using communication with remote computer and having features to read a large number of RF tags A method and system for providing point-of-sale and point-of-delivery and/or distribution of products in a restricted access unit near the customer. The method and system utilize products equipped with radio frequency tags and reduce the effects of energy sharing, s... | 02/16/2010 |
| 7591421 | Radio frequency identification method and system of distributing products A method and system for vending products from a defined area, such as a micro-warehouse with a door. The method includes fitting each product with a radio frequency identification tag, positioning the plurality of products in a micro-warehouse, sensing opening and c... | 09/22/2009 |
| 7560232 | Methods of capturing, detecting and quantifying RNA:DNA hybrids and a modified RNase H useful therein Methods for specific RNA capture, detection and quantification are presented utilizing a protein that selectively binds RNA:DNA hybrids, preferably an RNase H that is modified to reduce degradation of the nucleic acid molecules and enhance specific detection of mixe... | 07/14/2009 |
| 7553632 | Luminogenic and nonluminogenic multiplex assay A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided. ... | 06/30/2009 |
