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| Number | Title | Issue Date |
| 6706165 | Fabrication of metallic microstructures via exposure of photosensitive composition A method of forming microstructures. An article including a metal atom precursor is disproportionally exposed to electromagnetic radiation in an amount and intensity sufficient to convert some of the precursor to elemental metal. Additional conductive material may t... | 03/16/2004 |
| 6705357 | Method and apparatus for gradient generation A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess differ... | 03/16/2004 |
| 6696061 | Immunomodulatory peptides A purified preparation of a peptide consisting essentially of an amino acid sequence identical to that of a segment of a naturally-occurring human protein, said segment being of 10 to 30 residues in length, inclusive, wherein said peptide binds to a human... | 02/24/2004 |
| 6686184 | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materi... | 02/03/2004 |
| 6686198 | Method of inducing and maintaining neuronal cells The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems from the unexpected finding that, contrary to traditional u... | 02/03/2004 |
| 6677338 | Serotonin transport inhibitors The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.... | 01/13/2004 |
| 6673354 | Compositions and methods for treating papillomavirus-infected cells By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mamma... | 01/06/2004 |
| 6673615 | Characterization of individual polymer molecules based on monomer-interface interactions The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the interface having a channel so dimensioned as to allow sequentia... | 01/06/2004 |
| 6664075 | Nucleic acids encoding hedgehog proteins The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatia... | 12/16/2003 |
| 6653089 | Differential treatment of selected parts of a single cell with different fluid components The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in cer... | 11/25/2003 |
| 6632608 | Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or T cell subset activity by modulation of XBP-1 activity The invention demonstrates that the transcription factor XBP-1 is a regulator of hepatocyte growth, plasma cell differentiation and T cell subset activity. Methods for identifying modulators of hepatocyte growth, plasma cell differentiation and/or T cell ... | 10/14/2003 |
| 6627067 | Molecular and atomic scale evaluation of biopolymers A method for evaluating a polymer molecule including linearly connected monomer residues includes providing a polymer molecule in a liquid, contacting the liquid with an insulating solid-state membrane having a detector capable of detecting polymer molecu... | 09/30/2003 |
| 6610656 | Method of promoting chondrocyte differentiation with hedgehog related polypeptides The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spa... | 08/26/2003 |
| 6579695 | Phosphopantetheinyl transferases and uses thereof The invention pertains to isolated phosphopantetheinyl transferases, such as the E. coli acyl carrier protein synthase, which transfer a phosphopantetheinyl group onto a substrate. The enzyme can be purified from a natural source, produced recombinantly, ... | 06/17/2003 |
| 6576469 | Inducible methods for repressing gene function Methods for the rapid repression of gene function in eucaryotic cells are disclosed including inducible means for both shutting down a targeted gene's transcription and rapidly removing a targeted gene's polypeptide product.... | 06/10/2003 |
| 6576237 | Vertebrate tissue pattern-inducing proteins, and uses related thereto The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatia... | 06/10/2003 |
| 6576781 | Synthesis of pseudopterosin compounds The present invention is directed to the synthetic processes outlined in Schemes 1, 2 and 3, to the novel intermediates recited therein, and to the uses of these compounds as synthetic precursors to the pseudopterosins. Other embodiments and aspects of th... | 06/10/2003 |
| 6573365 | Antibodies for NF-AT interacting protein, NIP45 Isolated nucleic acid molecules encoding a novel protein, NIP45, that interacts with members of the Nuclear Factor of Activated T cell (NF-AT) family of proteins, are disclosed. The invention further provides antisense nucleic acid molecules, recombinant ... | 06/03/2003 |
| 6570432 | Integrator topology for continuous integration Provided are integrator circuit topologies that enable continuous integration without reset of the integrator circuit. One such integrator circuit includes a first integrator and a second integrator, each of the two integrators having a non-inverting term... | 05/27/2003 |
| 6569859 | Synthetic analogs of ecteinascidin-743 The present invention is directed to the synthesis and characterization of compounds having the formula: ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 | 05/27/2003 |
| 6552071 | Methods for treating cell death diseases and inflammation The present invention features methods and compounds for treating or preventing a cell death disease or inflammation, and methods for synthesizing wedelolactone.... | 04/22/2003 |
| 6548734 | Methods relating to modulation of cartilage cell growth and/or differentiation by modulation of NFATp activity The invention demonstrates that NFATp represses cartilage cell division and represses the chondrogenic program in cells and displays the properties of a tumor suppressor gene. In addition, the invention demonstrates that inhibition of NFATp activity promo... | 04/15/2003 |
| 6548290 | Geminin gene and protein The claimed invention pertains to a novel protein called Geminin which is able to inhibit DNA replication and/or induce neurogenesis. The claimed invention includes the amino acid sequence, the nucleic acid sequence, and various domains thereof. The inven... | 04/15/2003 |
| 6548021 | Surface-bound, double-stranded DNA protein arrays The invention provides a synthetic array of surface-bound, bimolecular, double-stranded nucleic acid molecules, the array comprising a solid support and a plurality of bimolecular double-stranded nucleic acid molecule members, a member comprising a first ... | 04/15/2003 |
| 6548041 | Dopamine transporter imaging agents Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine tr... | 04/15/2003 |
| 6548736 | 7B2 knockout transgenic animals as models of endocrine disease In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human ma... | 04/15/2003 |
| 6540999 | Immunomodulatory methods using Lewisx oligosacchardies Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least ... | 04/01/2003 |
| 6541203 | Detecting structural or synthetic information about chemical compounds The present invention provides an improved system for the rapid and non-destructive identification of chemical compounds attached to solid supports. In general, the invention provides an identification unit comprising a tag attached to the solid support a... | 04/01/2003 |
| 6541609 | HIV-2 peptides A substantially pure polypeptide having at least one antigenic determinant that is substantially identical to an antigenic determinant of a protein from a cell line infected with simian T-lymphotrophic virus-III or human T-lymphotrophic virus-IV (HTLV-IV)... | 04/01/2003 |
| 6541539 | Hierarchically ordered porous oxides A low-cost, efficient method of preparing hierarchically ordered structures by combining, concurrently or sequentially, micromolding, latex templating, and cooperative self-assembly of hydrolyzed inorganic species and amphiphilic block copolymers.... | 04/01/2003 |
| 6537810 | Methods for regulating T cell subsets by modulating transcription factor activity Methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of one or more transcription factors that cooperate with NF-AT family proteins to regulate expression of a Th2-associ... | 03/25/2003 |
| 6534497 | Substitute 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 11-phenyl-dibenzazepine compounds that are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach... | 03/18/2003 |
| 6534035 | Methods of inhibiting clot formation The invention provides methods of detecting blood in vivo and methods of inhibiting clot formation and promoting therapeutic thrombolysis using alpha-2 antiplasmin (P) polypeptides.... | 03/18/2003 |
| 6531574 | T-lymphotrophic virus A substantially pure polypeptide having at least one antigenic determinant that is substantially identical to an antigenic determinant of a protein from a cell line infected with a specified virus that has been deposited with the ATCC, the protein being s... | 03/11/2003 |
| 6528633 | Cyclin-selective ubiquitin carrier polypeptides Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for su... | 03/04/2003 |
| 6525206 | Compounds with high monoamine transporter affinity Featured compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out above. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat vari... | 02/25/2003 |
| 6521561 | Main-group metal based asymmetric catalysts and applications thereof The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive π-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucle... | 02/18/2003 |
| 6518168 | Self-assembled monolayer directed patterning of surfaces A technique for creating patterns of material deposited on a surface involves forming a self-assembled monolayer in a pattern on the surface and depositing, via chemical vapor deposition or via sol-gel processing, a material on the surface in a pattern co... | 02/11/2003 |
| 6514724 | Hedgehog interacting proteins and uses related thereto The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as "hedgehog interacting proteins" or "HIPs", which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the... | 02/04/2003 |
| 6514935 | Methods of treating hypertension The invention features a method of inhibiting hypertension in a mammal by administering to the mammal a compound that reduces expression or activity of SmLIM.... | 02/04/2003 |
