Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 4542096 | Detecting rearranged human c-myc DNA fragments associated with oncogenes Rearranged DNA fragments associated with oncogenes are detected by DNA hybridization to a labelled probe comprising DNA fragment subject to rearrangement.... | 09/17/1985 |
| 4490358 | Screening vaccines and immunization process Mammals are vaccinated against infectious organisms and polypeptides are screened for utility as vaccines by a complementing set of monoclonal antibodies, the first of which antibodies binds specifically to the site on the organism which itself binds spec... | 12/25/1984 |
| 4485265 | Photovoltaic cell In a photovoltaic cell structure containing a visibly transparent, electrically conductive first layer of metal oxide, and a light-absorbing semiconductive photovoltaic second layer, the improvement comprising a thin layer of transition metal nitride, car... | 11/27/1984 |
| 4456550 | Vascular permeability factor A purified vascular permeability protein factor and method of manufacture, wherein the factor has the following characteristics: (a) in an aqueous solution (0.01 M Na3 PO4, pH 7) whose concentration of NaCl is varied linearly, the factor ... | 06/26/1984 |
| 4456687 | Agents for promoting growth of epithelial cells Certain agents are disclosed which promote growth of epithelial cells, including human epidermal cells. These agents are known to increase the level of cellular cyclic-AMP.... | 06/26/1984 |
| 4452774 | Isonitrile radionuclide complexes for labelling and imaging agents A coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid m... | 06/05/1984 |
| 4435837 | Pattern recognition and orientation system A system that automatically scans the shape of a flat object located in a viewing field, recognizes the shape by identifying at least one moment (e.g., the first moment, area; the second moments, products of inertia; or a higher moment), calculates the ce... | 03/06/1984 |
| 4427653 | Method of making monoclonal antibodies Methods featuring, in one aspect, a method of preparing an antigen or mixture of antigens substantially free of antigens specific to at least two monoclonal antibodies, said method involving contacting an antigen mixture with one or more previously-isolat... | 01/24/1984 |
| 4418149 | Fused hybrid gene This invention is a process to produce specific proteins coded for by eukaryotic (or prokaryotic) DNA in bacteria. The invention, which uses recombinant DNA techniques, produces proteins in their natural, functional state unencumbered by extraneous peptid... | 11/29/1983 |
| 4415660 | Method of making a cloning vector A cloning vector useful in recombining DNA (i.e. recombinant DNA studies) is made by mutagenesis of a satellite bacteriophage P4 wt or P4 vir1 and subsequent separation and purification of the mutant progeny in a cesium chloride equilibrium den... | 11/15/1983 |
| 4415668 | Cell culture Improved cell culture microcarriers having controlled amphipathic (hydrophobic and polar) properties and controlled positive charge capacities, which make these microcarriers controllable in size in aqueous or non-aqueous environments and which produce ou... | 11/15/1983 |
| 4413233 | Dynamic NMR measurement Apparatus and method for dynamically measuring a chemical entity in living biological tissue having a physical characteristic capable of fluctuation, the apparatus including an NMR pulse spectrometer capable of providing an observation pulse for instantan... | 11/01/1983 |
| 4409550 | NMR Sodium images Apparatus for producing a sodium NMR image of sodium-containing biological tissue including an NMR pulse spectrometer capable of providing a plurality of simultaneous observation pulses and changing magnetic field gradients in order to produce an image, a... | 10/11/1983 |
| 4390629 | Polypeptide degrading enzymes Proteases derived from E. coli, and a method for preparing a proteinaceous mixture having proteolytic activity.... | 06/28/1983 |
| 4367222 | Immune globulin specific to Group B streptococci Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11×10 | 01/04/1983 |
| 4367221 | Immunization against Group B streptococci Culturing Strepococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11×10 | 01/04/1983 |
| 4367223 | Vaccine against Group B streptococci Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8.varies.11... | 01/04/1983 |
| 4356263 | Method of making a polysaccharide vaccine Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11×10 | 10/26/1982 |
| 4342748 | Sleep-promoting factor Sleep-promoting factor isolated from brains of sleep-deprived animals or from human urine and concentrated using ion-exchange resins.... | 08/03/1982 |
| 4338397 | Mature protein synthesis A method is provided for synthesizing within a bacterial host, and secreting through the membrane of the host, a selected mature protein or polypeptide. The method involves: (a) cleaving a cloning vehicle to form a cleavage site after a promoter of either... | 07/06/1982 |
| 4336336 | Fused gene and method of making and using same This invention is a method for fusing, within a bacterial host, a gene for a cytoplasmic protein to a gene for a non-cytoplasmic protein, so that the hybrid protein produced is transported to, near, or beyond the cell surface for ease of collection and pu... | 06/22/1982 |
| 4332892 | Protein synthesis This invention is a process to produce specific proteins coded for by eukaryotic (or prokaryotic) DNA in bacteria. The invention, which uses recombinant DNA techniques, produces proteins in their natural, functional state unencumbered by extraneous peptid... | 06/01/1982 |
| 4332901 | Cloning vector A cloning vector useful in recombining DNA (i.e. recombinant DNA studies) is made by mutagenesis of a satellite bacteriophage P4 wt or P4 vir1 and subsequent separation and purification of the mutant progeny in a cesium chloride equilibrium den... | 06/01/1982 |
| 4324887 | Type II group B Streptococci polysaccharide Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11×10 | 04/13/1982 |
| 4322537 | Tertiary amine oxidation and products thereof Tertiary amines in which at least one group bonded directly to the nitrogen atom is alkyl of 2 to 20 carbon atoms or in which two or more groups bonded directly to the nitrogen atom together are alkylene of 4 to 7 carbon atoms, are oxidized by trihaloacet... | 03/30/1982 |
| 4318401 | Percutaneous vascular access portal and catheter A percutaneous vascular access portal for implantation in a patient for an extended period of time including a cannula having a skirt at its distal end for attaching to the wall of a blood vessel and a flange at the other end to be located near the patien... | 03/09/1982 |
| 4318301 | Apparatus for measuring papillary muscle contractility Apparatus for measuring papillary muscle contractility when subjected to electrical stimulus while immersed in a test bathing liquid includes a test chamber for maintaining the liquid at a controlled temperature and having a membrane for diffusion of oxyg... | 03/09/1982 |
| 4278761 | Enzyme assay and kit therefor Compositions and methods featuring, in one aspect, an enzyme assay in which one of a pair of enzymes is immobilized on an insoluble support, and brought into contact with a solution containing the other enzyme of the pair and the substrates of both enzyme... | 07/14/1981 |
| 4264737 | Method of making genetically stable mutants of vibrio cholerae Incubation of a parent strain of Vibrio cholerae at elevated temperature to produce a hypotoxinogenic variant strain and mutation of the variant strain results in mutant strains which retain the biotype and antigens of the parent strain, and which are gen... | 04/28/1981 |
| 4256743 | Inhibition of bone resorption with H1 -blocking antihistamines Inhibition of bone resorption in mammals suffering from a disease in which bone resorption exceeds new bone formation by administering an H1 -blocking antihistamine.... | 03/17/1981 |
| 4217412 | Production of tumor angiogenesis factor by cell culture Process for the production of human TAF in vitro comprising growing the human medulloblastoma cell line TE-671 in agitated, liquid suspension of nutrient culture medium at about 35°-38° C. for a sufficient time to elaborate TAF and recovering the resul... | 08/12/1980 |
| 4207414 | Polysaccharide antigens Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8-11×10 | 06/10/1980 |
| 4131727 | Method of purifying alcohol dehydrogenase and affinity resin therefor An affinity resin containing pyrazole immobilized on a solid insoluble support by a coupling arm bonded at the 4-position having a length of at least 12 Angstrom units is used to purify and fractionate crude alcohol dehydrogenase extract into a pyrazole-b... | 12/26/1978 |
| 4111751 | Method of purifying alcohol dehydrogenase An affinity resin containing pyrazole immobilized on a solid insoluble support by a coupling arm bonded at the 4-position having a length of at least 12 Angstrom units is used to purify and fractionate crude alcohol dehydrogenase extract into a pyrazole-b... | 09/05/1978 |
| 4021387 | Eosinophilotactic tetrapeptides Two eosinophilotactic tetrapeptides of amino acid sequence Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu have been isolated from extracts of human lung fragments. These tetrapeptides have been synthesized by solid phase peptide synthesis procedures and the syntheti... | 05/03/1977 |
