Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8093262 | Use of huperzine for disorders Methods and compositions containing huperzine are used to prevent and alleviate neuropathic pain. The invention is also directed to methods and compositions for using huperzine for the prevention and/or treatment of neuropathic pain and orthostatic hypotension. ... | 01/10/2012 |
| 8093009 | Mass spectrometric methods and products The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects. ... | 01/10/2012 |
| 8092697 | Molecular characterization with carbon nanotube control In a method for fabricating a molecule characterization device, there is formed an aperture in a support structure, and electrical contact pads are formed on a selected surface of the support structure for connection to molecular analysis circuitry. Then at the aper... | 01/10/2012 |
| 8088951 | Epigenetic mechanisms re-establish access to long-term memory after neuronal loss The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation. ... | 01/03/2012 |
| 8088816 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl) -3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative... | 01/03/2012 |
| 8084596 | Regulated apoptosis We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genet... | 12/27/2011 |
| 8084205 | Genetic risk assessment technology for epithelial cancer involving gene-environment interaction between ERCC5 and tobacco use Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are provided. ... | 12/27/2011 |
| 8080467 | Silicon-based visible and near-infrared optoelectric devices In one aspect, the present invention provides a silicon photodetector having a surface layer that is doped with sulfur inclusions with an average concentration in a range of about 0.5 atom percent to about 1.5 atom percent. The surface layer forms a diode junction w... | 12/20/2011 |
| 8080394 | Method for determining predisposition to pulmonary infection Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful... | 12/20/2011 |
| 8080203 | Air sterilization apparatus An air sterilization apparatus for sterilizing air that can include a fan assembly, which may be mounted in an upper-part of a room, and a UVC lamp to emit a UVGI field. The air sterilization apparatus may direct air across the UVGI field to sterilize the air. A baf... | 12/20/2011 |
| 8076662 | Electric field induced phase transitions and dynamic tuning of the properties of oxide structures Phase transitions (such as metal-insulator transitions) are induced in oxide structures (such as vanadium oxide thin films) by applying an electric field. The electric field-induced phase transitions are achieved in VO2 structures that scale down to nanom... | 12/13/2011 |
| 8076151 | Ultra-sensitive temperature sensing and calorimetry Methods and apparatus for ultra-sensitive temperature sensing and calorimetry. Radiation is directed at a thin electrically conductive film having one or more small apertures. The incident radiation excites surface plasmons on a first surface of the electrically con... | 12/13/2011 |
| 8076116 | Nucleic acids encoding class II human histone deacetylases, and uses related thereto The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors. ... | 12/13/2011 |
| 8071314 | Immunocellular receptors related to neurological disorders and therapeutic uses thereof Class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Similarities in the ... | 12/06/2011 |
| 8067237 | Scaffolds for cell transplantation A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident c... | 11/29/2011 |
| 8058640 | Branched nanoscale wires The present invention generally relates to nanotechnology and, in particular, to branched nanoscale wires. In some cases, the branched nanoscale wires may be produced using vapor-phase and/or solution-phase synthesis. Branched nanoscale wires may be grown by deposit... | 11/15/2011 |
| 8048672 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet polypeptides, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which ... | 11/01/2011 |
| 8044089 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative,... | 10/25/2011 |
| 8031092 | Dual-mode based digital background calibration of pipelined ADCs for gain variations and device mismatches Methods and systems are described relating to dual-mode based digital background calibration of pipelined ADCs, for gain variations and device mismatches. Errors caused by gain insufficiency, nonlinearity, and capacitor mismatches are corrected by operating one ADC ... | 10/04/2011 |
| 8030057 | Fluid delivery system and method Method and device for storing and/or delivering fluids, wherein at least a first and a second fluid, such as chemical or biochemical reagents or rinse solutions, are maintained separately from each other in a common vessel and transferred in series from the vessel t... | 10/04/2011 |
| 8026224 | Tumor cells with increased immunogenicity and uses therfor Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic a... | 09/27/2011 |
| 8024274 | Practical secrecy-preserving, verifiably correct and trustworthy auctions A system and method for conducting verifiably correct auctions that preserves the secrecy of the bids while providing for verifiable correctness and trustworthiness of the auction is disclosed. Some of the elements of the method and apparatus are that the auction op... | 09/20/2011 |
| 8021532 | Dielectrophoretic tweezers apparatus and methods Dielectrophoretic (DEP) tweezers apparatus and methods for various applications, including particle trapping. Multiple electrodes (e.g., two or three) are disposed on or otherwise constitute an elongated object forming a tip. Exemplary electrode configurations inclu... | 09/20/2011 |
| 8017755 | RNA-based transcriptional regulators RNA molecules have been shown to play a variety of functional roles in biological processes. RNA sequences can adopt 3-D conformations able to regulate transcription. RNA-based transcriptional regulators when recruited to a DNA template act to promote or suppress th... | 09/13/2011 |
| 8017634 | Compositions for treating obesity and insulin resistance disorders Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activ... | 09/13/2011 |
| 8017323 | Free reactant use in nucleic acid-templated synthesis The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates ... | 09/13/2011 |
| 8017125 | Copolymers for suppression of autoimmune diseases, and methods of use Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymer... | 09/13/2011 |
| 8014430 | Quantum cascade laser A quantum cascade laser utilizing non-resonant extraction design having a multilayered semiconductor with a single type of carrier; at least two final levels (1 and 1′) for a transition down from level 2; an energy spacing E21 great... | 09/06/2011 |
| 8012382 | Molded waveguides Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A c... | 09/06/2011 |
| 8011229 | Determining postural stability A method for determining postural stability of a person can include acquiring a plurality of pressure data points over a period of time from at least one pressure sensor. The method can also include the step of identifying a postural state for each pressure data poi... | 09/06/2011 |
| 8008743 | Vapor deposition of silicon dioxide nanolaminates This invention relates to materials and processes for thin film deposition on solid substrates. Silica/alumina nanolaminates were deposited on heated substrates by the reaction of an aluminum-containing compound with a silanol. The nanolaminates have very uniform th... | 08/30/2011 |
| 8008024 | Methods, products and treatments for diabetes The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided. ... | 08/30/2011 |
| 8008014 | Capture, recapture, and trapping of molecules with a nanopore In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopo... | 08/30/2011 |
| 7998904 | Evolving new molecular function Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecul... | 08/16/2011 |
| 7994362 | Histone deacetylases, and uses related thereto The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available composi... | 08/09/2011 |
| 7993905 | Device containing cytophilic islands that adhere cells separated by cytophobic regions The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells... | 08/09/2011 |
| 7993538 | Patterning by energetically-stimulated local removal of solid-condensed-gas layers and solid state chemical reactions produced with such layers The invention provides a method for forming a patterned material layer on a structure, by condensing a vapor to a solid condensate layer on a surface of the structure and then localized removal of selected regions of the condensate layer by directing a beam of energ... | 08/09/2011 |
| 7985546 | Genomic library construction Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided. ... | 07/26/2011 |
| 7977049 | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g... | 07/12/2011 |
| 7974325 | Methods and apparatus for generating terahertz radiation Apparatus and methods for generating radiation via difference frequency generation (DFG). In one exemplary implementation, a quantum cascade laser (QCL) has a significant second-order nonlinear susceptibility (χ(2)) integrated in an active region of the ... | 07/05/2011 |
