Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 8183178 | Iterated branching reaction pathways via nucleic acid-mediated chemistry The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermed... | 05/22/2012 |
| 8180717 | System for estimating a distribution of message content categories in source data A method of computerized content analysis that gives “approximately unbiased and statistically consistent estimates” of a distribution of elements of structured, unstructured, and partially structured source data among a set of categories. In one embodiment, thi... | 05/15/2012 |
| 8178907 | Nanoscopic wire-based electrical crossbar memory-devices and arrays Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surf... | 05/15/2012 |
| 8178579 | Dioxanes and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivati... | 05/15/2012 |
| 8178316 | Evaluating proteins The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affin... | 05/15/2012 |
| 8168159 | Compounds for tumor diagnosis and therapy The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that ar... | 05/01/2012 |
| 8154354 | Nonlinear pulse oscillator methods and apparatus Methods and apparatus for implementing stable self-starting and self-sustaining high-speed electrical nonlinear pulse (e.g., soliton, cnoidal wave, or quasi-soliton) oscillators. Chip-scale nonlinear pulse oscillator devices may be fabricated using III-V semiconduct... | 04/10/2012 |
| 8154002 | Nanoscale wire-based data storage The present invention generally relates to nanotechnology and submicroelectronic devices that can be used in circuitry and, in some cases, to nanoscale wires and other nanostructures able to encode data. One aspect of the invention provides a nanoscale wire or other... | 04/10/2012 |
| 8153470 | Doped elongated semiconductors, growing such semiconductors, devices including such semiconductors, and fabricating such devices A method for selectively aligning and positioning semiconductor nanowires on a substrate by providing a substrate; patterning electrodes on a surface of the substrate; conditioning the surface of the substrate to attach semiconductor nanowires to the surface by func... | 04/10/2012 |
| 8153432 | Multiplex automated genome engineering The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells. ... | 04/10/2012 |
| 8143686 | Laser-induced structuring of substrate surfaces In one aspect, the present invention provides a method of processing a substrate, e.g., a semiconductor substrate, by irradiating a surface of the substrate (or at least a portion of the surface) with a first set of polarized short laser pulses while exposing the su... | 03/27/2012 |
| 8143300 | Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u... | 03/27/2012 |
| 8124743 | Purification of a bivalently active antibody using a non-chromatographic method The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immu... | 02/28/2012 |
| 8119032 | Gas-phase functionalization of surfaces including carbon-based surfaces The invention provides methods functionalizing a planar surface of a graphene layer, a graphite surface, or microelectronic structure. The graphene layer, graphite surface, or planar microelectronic structure surface is exposed to at least one vapor including at lea... | 02/21/2012 |
| 8093262 | Use of huperzine for disorders Methods and compositions containing huperzine are used to prevent and alleviate neuropathic pain. The invention is also directed to methods and compositions for using huperzine for the prevention and/or treatment of neuropathic pain and orthostatic hypotension. ... | 01/10/2012 |
| 8093009 | Mass spectrometric methods and products The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects. ... | 01/10/2012 |
| 8092697 | Molecular characterization with carbon nanotube control In a method for fabricating a molecule characterization device, there is formed an aperture in a support structure, and electrical contact pads are formed on a selected surface of the support structure for connection to molecular analysis circuitry. Then at the aper... | 01/10/2012 |
| 8088951 | Epigenetic mechanisms re-establish access to long-term memory after neuronal loss The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation. ... | 01/03/2012 |
| 8088816 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl) -3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative... | 01/03/2012 |
| 8084596 | Regulated apoptosis We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genet... | 12/27/2011 |
| 8084205 | Genetic risk assessment technology for epithelial cancer involving gene-environment interaction between ERCC5 and tobacco use Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are provided. ... | 12/27/2011 |
| 8080467 | Silicon-based visible and near-infrared optoelectric devices In one aspect, the present invention provides a silicon photodetector having a surface layer that is doped with sulfur inclusions with an average concentration in a range of about 0.5 atom percent to about 1.5 atom percent. The surface layer forms a diode junction w... | 12/20/2011 |
| 8080394 | Method for determining predisposition to pulmonary infection Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful... | 12/20/2011 |
| 8080203 | Air sterilization apparatus An air sterilization apparatus for sterilizing air that can include a fan assembly, which may be mounted in an upper-part of a room, and a UVC lamp to emit a UVGI field. The air sterilization apparatus may direct air across the UVGI field to sterilize the air. A baf... | 12/20/2011 |
| 8076662 | Electric field induced phase transitions and dynamic tuning of the properties of oxide structures Phase transitions (such as metal-insulator transitions) are induced in oxide structures (such as vanadium oxide thin films) by applying an electric field. The electric field-induced phase transitions are achieved in VO2 structures that scale down to nanom... | 12/13/2011 |
| 8076151 | Ultra-sensitive temperature sensing and calorimetry Methods and apparatus for ultra-sensitive temperature sensing and calorimetry. Radiation is directed at a thin electrically conductive film having one or more small apertures. The incident radiation excites surface plasmons on a first surface of the electrically con... | 12/13/2011 |
| 8076116 | Nucleic acids encoding class II human histone deacetylases, and uses related thereto The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors. ... | 12/13/2011 |
| 8071314 | Immunocellular receptors related to neurological disorders and therapeutic uses thereof Class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Similarities in the ... | 12/06/2011 |
| 8067237 | Scaffolds for cell transplantation A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident c... | 11/29/2011 |
| 8058640 | Branched nanoscale wires The present invention generally relates to nanotechnology and, in particular, to branched nanoscale wires. In some cases, the branched nanoscale wires may be produced using vapor-phase and/or solution-phase synthesis. Branched nanoscale wires may be grown by deposit... | 11/15/2011 |
| 8048672 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet polypeptides, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which ... | 11/01/2011 |
| 8044089 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative,... | 10/25/2011 |
| 8031092 | Dual-mode based digital background calibration of pipelined ADCs for gain variations and device mismatches Methods and systems are described relating to dual-mode based digital background calibration of pipelined ADCs, for gain variations and device mismatches. Errors caused by gain insufficiency, nonlinearity, and capacitor mismatches are corrected by operating one ADC ... | 10/04/2011 |
| 8030057 | Fluid delivery system and method Method and device for storing and/or delivering fluids, wherein at least a first and a second fluid, such as chemical or biochemical reagents or rinse solutions, are maintained separately from each other in a common vessel and transferred in series from the vessel t... | 10/04/2011 |
| 8026224 | Tumor cells with increased immunogenicity and uses therfor Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic a... | 09/27/2011 |
| 8024274 | Practical secrecy-preserving, verifiably correct and trustworthy auctions A system and method for conducting verifiably correct auctions that preserves the secrecy of the bids while providing for verifiable correctness and trustworthiness of the auction is disclosed. Some of the elements of the method and apparatus are that the auction op... | 09/20/2011 |
| 8021532 | Dielectrophoretic tweezers apparatus and methods Dielectrophoretic (DEP) tweezers apparatus and methods for various applications, including particle trapping. Multiple electrodes (e.g., two or three) are disposed on or otherwise constitute an elongated object forming a tip. Exemplary electrode configurations inclu... | 09/20/2011 |
| 8017755 | RNA-based transcriptional regulators RNA molecules have been shown to play a variety of functional roles in biological processes. RNA sequences can adopt 3-D conformations able to regulate transcription. RNA-based transcriptional regulators when recruited to a DNA template act to promote or suppress th... | 09/13/2011 |
| 8017634 | Compositions for treating obesity and insulin resistance disorders Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activ... | 09/13/2011 |
| 8017323 | Free reactant use in nucleic acid-templated synthesis The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates ... | 09/13/2011 |
