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| Number | Title | Issue Date |
| 7667497 | Process variation tolerant circuit with voltage interpolation and variable latency A circuit having dynamically controllable power. The circuit comprises a plurality of pipelined stages, each of the pipelined stages comprising two clocking domains, a plurality of switching circuits, each switching circuit being connected to one of the pipelined st... | 02/23/2010 |
| 7666708 | Doped elongated semiconductors, growing such semiconductors, devices including such semiconductors, and fabricating such devices A bulk-doped semiconductor that is at least one of the following: a single crystal, an elongated and bulk-doped semiconductor that, at any point along its longitudinal is, axis, has a largest cross-sectional dimension less than 500 nanometers, and a free-standing an... | 02/23/2010 |
| 7659053 | Methods of alteration of surface affinities using non-chemical force-creating fields The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/... | 02/09/2010 |
| 7625706 | Methods and apparatus for characterizing polynucleotides Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase,... | 12/01/2009 |
| 7619290 | Nanosensors Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized. Nanodetector devices are described. ... | 11/17/2009 |
| 7615380 | Methods for modulating an immune response by modulating KRC activity This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation, increasing TNF-alpha induced apoptosis, inhibiting JNK activation, in... | 11/10/2009 |
| 7611892 | Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of the prostate and testis, such as cancer. ... | 11/03/2009 |
| 7595260 | Doped elongated semiconductors, growing such semiconductors, devices including such semiconductors, and fabricating such devices A bulk-doped semiconductor may be at least one of the following: a single crystal, an elongated and bulk-doped semiconductor that at any point along its longitudinal axis, has a largest cross-sectional dimension less than 500 nanometers, and a free-standing and bulk... | 09/29/2009 |
| 7585671 | Hedgehog interacting proteins and uses related thereto The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the v... | 09/08/2009 |
| 7582490 | Controlled fabrication of gaps in electrically conducting structures A method for controlling a gap in an electrically conducting solid state structure provided with a gap. The structure is exposed to a fabrication process environment conditions of which are selected to alter an extent of the gap. During exposure of the structure to ... | 09/01/2009 |
| 7575889 | Compound combinations for inhibiting cell division and methods for their identification and use The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compoun... | 08/18/2009 |
| 7575856 | Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant The present invention describes devices, solutions, and methods for the ex-vivo assessment, resuscitation, triage, and maintenance of human candidate cadaveric hearts. ... | 08/18/2009 |
| 7566808 | Management of ophthalmologic disorders, including macular degeneration A drug may be used in the preparation of a medicament for the treatment or prevention of an ophthalmologic disorder, wherein the drug inihibits, antagonizes, or short-circuits the visual cycle at a step of the visual cycle that occurs outside a disc of a rod photore... | 07/28/2009 |
| 7566767 | Synthetic peptides and methods of use for autoimmune disease therapies The invention provides peptide compositions, and methods of making and using therapeutic compositions for treatment of a subject for an autoimmune or an inflammatory disease. The invention also provides kits for assaying binding of a composition to a water-soluble M... | 07/28/2009 |
| 7560581 | Vapor deposition of tungsten nitride Tungsten nitride films were deposited on heated substrates by the reaction of vapors of tungsten bis(alkylimide)bis(dialkylamide) and a Lewis base or a hydrogen plasma. For example, vapors of tungsten bis(tert-butylimide)bis(dimethylamide) and ammonia gas supplied i... | 07/14/2009 |
| 7557229 | Atomic layer deposition using metal amidinates Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) N,N′-diisopropylacetamidinate vapor and hydrogen gas. Cobalt metal films were dep... | 07/07/2009 |
| 7557068 | Evolving new molecular function Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecul... | 07/07/2009 |
| 7556776 | Microfluidic manipulation of fluids and reactions The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including microreactors for manipulating fluids and reactions. In some embodiments, structures and methods for manipulating many (e.g., ... | 07/07/2009 |
| 7553478 | Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient ... | 06/30/2009 |
| 7546517 | Error-correcting circuit for high density memory This invention relates to a circuit technique for rapidly and efficiently correcting for read and write data errors in a digital semiconductor memory. More generally, this can also be in any type of digital memory or digital communication channel. As semiconductor m... | 06/09/2009 |
| 7544497 | Compositions for manipulating the lifespan and stress response of cells and organisms Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activatin... | 06/09/2009 |
| 7542137 | Pathogen detection using coherent anti-stokes Raman scattering microscopy The invention provides a system and method for automatic real-time monitoring for the presence of a pathogen in water using coherent anti-stokes Raman scattering (CARS) microscopy. Water sample trapped in a trapping medium is provided to a CARS imager. CARS images a... | 06/02/2009 |
| 7541450 | Ligand-dependent protein splicing Ligand-dependent inteins allow for modulation of a protein's activity in vivo. Upon binding of the ligand to the ligand-dependent intein inserted into the protein of interest, the hybrid protein undergoes protein splicing removing the intein. The activity of the spl... | 06/02/2009 |
| 7524431 | Lift-off patterning processing employing energetically-stimulated local removal of solid-condensed-gas layers The invention provides a method for forming a patterned material layer on a structure, by condensing a vapor to a solid condensate layer on a surface of the structure and then localized removal of selected regions of the condensate layer by directing a beam of energ... | 04/28/2009 |
| 7514067 | Methods for tumor diagnosis and therapy The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that ar... | 04/07/2009 |
| 7511156 | Analogs of Salinosporamide A Disclosed herein are analogs of Salinosporamide A, having the Formulae Ia-IVa as follows: Like Salinosporamide A, the compounds of the present invention will inhibit the proteasome, an intracellular enzyme complex that dest... | 03/31/2009 |
| 7507848 | Vapor deposition of metal oxides, silicates and phosphates, and silicon dioxide Metal silicates or phosphates are deposited on a heated substrate by the reaction of vapors of alkoxysilanols or alkylphosphates along with reactive metal amides, alkyls or alkoxides. For example, vapors of tris(tert-butoxy)silanol react with vapors of tetrakis(ethy... | 03/24/2009 |
| 7501286 | Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry The invention provides reagents, kits and methods for detecting and/or quantifying proteins in complex mixtures, such as a cell lysate. The methods can be used in high throughput assays to profile cellular proteomes. In one aspect, the invention provides a peptide i... | 03/10/2009 |
| 7500213 | Array-based architecture for molecular electronics An architecture for nanoscale electronics is disclosed. The architecture comprises arrays of crossed nanoscale wires having selectively programmable crosspoints. Nanoscale wires of one array are shared by other arrays, thus providing signal propagation between the a... | 03/03/2009 |
| 7491494 | Evolving new molecular function Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provid... | 02/17/2009 |
| 7476740 | Tropane compounds The present invention provides novel tropane compounds and methods for their use. ... | 01/13/2009 |
| 7476596 | Doped elongated semiconductors, growing such semiconductors, devices including such semiconductors, and fabricating such devices A bulk-doped semiconductor that is at least one of the following: a single crystal, an elongated and bulk-doped semiconductor that, at any point along its longitudinal axis, has a largest cross-sectional dimension less than 500 nanometers, and a free-standing and bu... | 01/13/2009 |
| 7476500 | In vivo selection system for enzyme activity The present invention provides in vivo systems in which activity of a biological cleavage enzyme, such as a site-specific recombinase, a homing endonuclease, or an intein, is linked to cell viability and therefore can be selected. The invention further provides meth... | 01/13/2009 |
| 7468271 | Molecular characterization with carbon nanotube control There is provided a first reservoir containing a liquid solution including a molecule to be characterized and a second reservoir for containing a liquid solution including a molecule that has been characterized. A solid state support structure is provided including ... | 12/23/2008 |
| 7466069 | Carbon nanotube device fabrication A carbon nanotube device in accordance with the invention includes a support structure including an aperture extending from a front surface to a back surface of the structure. At least one carbon nanotube extends across the aperture and is accessible through the ape... | 12/16/2008 |
| 7465720 | Proteasome inhibiting β-lactam compounds Disclosed is a total synthesis of a biologically active β-Lactam—Compound 3, which is related to Salinosporamide A and Omuralide, both structurally and by its activity as a proteasome inhibitor. Also disclosed are protea... | 12/16/2008 |
| 7462447 | Methods for evaluating susceptibility to a bone homeostasis disorder The invention provides mutant SH3-binding protein (SH3BP2) nucleic acids, polypeptides, and agents which selectively bind to the mutant SH3BP2 molecules and which do not bind to the wild type SH3BP2 molecules. Methods for selecting agents which inhibit mutant SH3BP2... | 12/09/2008 |
| 7456252 | Therapeutic peptides for demyelinating conditions The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition. ... | 11/25/2008 |
| 7446880 | Method and apparatus for measuring and monitoring optical properties based on a ring-resonator A method and apparatus for performing refractive index, birefringence and optical activity measurements of a material such as a solid, liquid, gas or thin film. The apparatus has an optical ring-resonator with a closed optical path that constitutes a cavity. A sampl... | 11/04/2008 |
| 7442783 | Natural IgM antibodies and inhibitors thereof The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders. ... | 10/28/2008 |