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| Number | Title | Issue Date |
| 7947708 | Compounds modulating C-kit activity Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand ... | 05/24/2011 |
| 7893075 | Compounds modulating c-fms and/or c-kit activity and uses therefor Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for th... | 02/22/2011 |
| 7846941 | Compounds modulating c-kit and c-fms activity and uses therefor Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use th... | 12/07/2010 |
| 7872018 | Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. ... | 01/18/2011 |
| 7863289 | Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. ... | 01/04/2011 |
| 7863288 | Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. ... | 01/04/2011 |
| 7759475 | Enzyme expression methods and compositions Methods for expressing active enzymes are described that involve co-expressing a first enzyme with a second enzyme that has an enzymatic activity that reverses a modification on the first enzyme and/or for identification of soluble and/or active catalytic domains by... | 07/20/2010 |
| 7723374 | PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. ... | 05/25/2010 |
| 7605168 | PDE4B inhibitors Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and ... | 10/20/2009 |
| 7585859 | PDE4B inhibitors and uses therefor Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof. ... | 09/08/2009 |
| 7572806 | PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. ... | 08/11/2009 |
| 7531568 | PPAR active compounds Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ. ... | 05/12/2009 |
| 7517970 | Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same Methods for expressing active enzymes are described that involve co-expressing a first enzyme with a second enzyme that has an enzymatic activity that reverses a modification on the first enzyme and/or for identification of soluble and/or active catalytic domains by... | 04/14/2009 |
| 7498342 | Compounds modulating c-kit activity Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand ... | 03/03/2009 |
| 7491831 | PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. ... | 02/17/2009 |
| 7476746 | PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. ... | 01/13/2009 |
| 7348338 | PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. ... | 03/25/2008 |
| 7202266 | PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. ... | 04/10/2007 |
