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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8153140 | Chimeric MSP-based malaria vaccine The invention provides an immunogenic composition comprising MSP-8 linked to an antigen. Methods of using the composition to induce an immune response in an animal are also provided. ... | 04/10/2012 |
| 8092805 | Dual inhibitors of HIV-1 gp-120 interactions Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided. ... | 01/10/2012 |
| 7939274 | Prostate cancer-related compositions, methods and kits based on DNA macroarray proteomics platforms The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates t... | 05/10/2011 |
| 7790861 | Prostate cancer-related compositions, methods, and kits based on DNA macroarray proteomics platforms The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates t... | 09/07/2010 |
| 7754435 | Prostate cancer-related compositions, methods, and kits based on DNA macroarray proteomics platforms The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates t... | 07/13/2010 |
| 7732577 | Isolated antibody specific for a mammalian MDM2 binding protein comprising SEQ ID No. 2 or 4 Isolated nucleic acid sequences encoding mammalian MDM2 binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and anti... | 06/08/2010 |
| 7674465 | Regulation of gene expression by the ARP The invention provides a novel gene and protein regulating the expression of Bacillus anthracis Anthrolysin O toxin, pharmaceutical compositions and antibodies which may be utilized for human or veterinary applications or for agricultural applications, and me... | 03/09/2010 |
| 7588912 | Compositions and methods for preventing and treating anthrax diseases Compounds, methods for identifying compounds and methods for using compounds which modulate interaction of lethal factor and anthrolysin O in the treatment and prevention of anthrax diseases are provided. ... | 09/15/2009 |
| 7556808 | Dual inhibitors of HIV-1 gp-120 interactions Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided. ... | 07/07/2009 |
| 7521073 | Compositions and methods for activating Toll-like receptor 4 Methods for activating Toll-like receptor 4 via cholesterol-dependent cytolysins isolated from a Gram-positive bacteria are provided. In addition compositions containing an isolated cholesterol-dependent cytolysin or a fragment thereof or a mimetic of the cytolysin ... | 04/21/2009 |
| 7374937 | Isolation and expansion of human marrow stromal cells The invention includes in vitro methods of inducing and enhancing proliferation of human marrow stromal cells for use in, for example, gene therapy and transplantation methods. The invention also includes a method of assessing the expandability (i.e., proliferative ... | 05/20/2008 |
| 7304142 | Mammalian MDM2 binding proteins Isolated nucleic acid sequences encoding mammalian MDM2 binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and anti... | 12/04/2007 |
| 7279331 | Differentiation of bone marrow cells into neuronal cells and uses therefor The present invention relates to methods of inducing differentiation of mammalian bone marrow stromal cells into neuronal cells by contacting marrow stromal cells with a neuronal differentiation-inducing compounds. Neuronal differentiation-inducing compounds of the ... | 10/09/2007 |
| 7056738 | Early stage multipotential stem cells in colonies of bone marrow stromal cells Marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells ... | 06/06/2006 |
| 6979447 | Immunomodulation and effect on cell processes relating to serotonin family receptors The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the trea... | 12/27/2005 |
| 6884423 | Antimicrobial histone H1 compositions, kits, and methods of use thereof The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. Th... | 04/26/2005 |
| 6565854 | Antimicrobial histone H1 compositions, kits, and methods of use thereof The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic b... | 05/20/2003 |
| 6380161 | Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions The present invention provides methods and compositions for treating cancer and chemotherapy-resistant cancers comprising a chemotherapeutic agent conjugated to or coadministered with a peptide.... | 04/30/2002 |
| 6365151 | Cellular immunogens comprising cognate proto-oxogenes A cellular immunogen is provided for immunizing a host against the effects of the product of a target proto-oncogene, where the overexpression of the target proto-oncogene is associated with a malignancy. The cellular immunogen comprises host cells which ... | 04/02/2002 |
