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| Number | Title | Issue Date |
| 6083990 | Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones The present invention discloses the use of permanently charged steroid agonists or antagonists as potent anti-angiogenic compositions comprising as an active ingredient a compound of the general formulae I, II or III: ##STR1## wherein DRUG is any ste... | 07/04/2000 |
| 5993846 | Bioadhesive emulsion preparations for enhanced drug delivery The invention relates to novel methods for making oil-in-water emulsions having mucoadhesive properties which are primarily intended for administration of biologically active compounds to mucosal surfaces. The emulsion has an aqueous continuous phase and ... | 11/30/1999 |
| 5961970 | Submicron emulsions as vaccine adjuvants A vaccine adjuvant composition of an oil-in-water submicron emulsion that has about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, about 0.05 to 5% of a nonionic surfactant, about 0.00001 to 1% of an im... | 10/05/1999 |
| 5891469 | Solid Coprecipitates for enhanced bioavailability of lipophilic substances Lipophilic active ingredients are co-melted with tocopherol polyethyleneglycol succinate (TPGS) and a dispersion adjuvant to obtain solid dry coprecipitate compositions suitable as an oral dosage form. The solid TPGS coprecipitates of lipophilic active in... | 04/06/1999 |
| 5750142 | Dry compositions for preparing submicron emulsions The present invention relates to dry, stable compositions which can be reconstituted to form pharmaceutical or cosmetic emulsions, and to methods for making such compositions. An emulsion is formed from about 0.2 to 25 weight percent of a first component ... | 05/12/1998 |
| 5716637 | Solid fat nanoemulsions as vaccine delivery vehicles The present invention provides pharmaceutical vaccine compositions that are nanoemulsions of particles having a lipid core which is in a solid or liquid crystalline phase at 25° C., and which is surrounded by at least one phospholipid bilayer for the par... | 02/10/1998 |
| 5662932 | Solid fat nanoemulsions The present invention provides pharmaceutical compositions comprising nanoemulsions of particles comprising a lipid core which is in a solid or liquid crystalline phase at 25° C., stabilized by at least one phospholipid envelope, for the parenteral, oral... | 09/02/1997 |
| 5650425 | Permanently ionic derivatives of steroid hormones and their antagonists The present disclosure relates to compounds of the general formulae: ##STR1## wherein DRUG is a steroid agonist or antagonist, a mixed agonist-antagonist, or a partial agonist, and to the use of such compounds as anti-inflammatory and anti-tumor agen... | 07/22/1997 |
| 5576311 | Cyclodextrins as suspending agents for pharmaceutical suspensions The present invention relates to stable aqueous suspension of drugs suitable for therapeutic administration without requiring solubilization or complexation of those drugs. The suspensions are stabilized with cyclodextrin type suspending agents. Stabilize... | 11/19/1996 |
| 5576016 | Solid fat nanoemulsions as drug delivery vehicles The present invention provides pharmaceutical compositions comprising nanoemulsions of particles comprising a lipid core which is in a solid or liquid crystalline phase at 25° C, stabilized by at least one phospholipid envelope, for the parenteral, oral,... | 11/19/1996 |
| 5540930 | Suspension of loteprednol etabonate for ear, eye, or nose treatment The invention provides novel compositions of matter containing water-insoluble steroid drugs suitable for therapeutic use. The invention provides stable aqueous suspensions of water-insoluble steroid drugs of particle sizes of ࣘ15 μm which remain in su... | 07/30/1996 |
| 5514670 | Submicron emulsions for delivery of peptides The present invention provides emulsions comprising a plurality of submicron particles, a bioactive peptide, and an aqueous continuous phase or that effect enhanced oral bioavailability of the peptide. Another aspect of the invention provides compositions... | 05/07/1996 |
