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| Number | Title | Issue Date |
| 5591767 | Liquid reservoir transdermal patch for the administration of ketorolac The invention is directed to a patch for the transdermal delivery of the racemic form or the active enantiomer of the analgesic ketorolac. The transdermal patch is capable of delivering therapeutically effective doses of the drug for a period of 12 hours ... | 01/07/1997 |
| 5589498 | Transdermal delivery of the active enantiomer of ketorolac The invention provides for the transdermal delivery of the active enantiomer of the analgesic ketorolac. Transdermal patches according to the invention are capable of delivering (-) ketorolac to a patient at therapeutically effective levels, at a flux rat... | 12/31/1996 |
| 5492534 | Controlled release portable pump A portable pump, useful for medical and non-medical uses, has two pouches (3, 4) in pressure transmitting relationship, the first (4) containing an infusate (5) and the second (3), a driving medium (2). The driving medium is pressurized in any of a variet... | 02/20/1996 |
| 5490415 | Diffusion test apparatus and method A diffusion test apparatus (2), used to test diffusion of a drug within a vehicle through a test membrane (8), includes a receiver assembly (6) and a donor assembly (4) secured to one another. The receiver assembly includes a number of open-top receiver r... | 02/13/1996 |
| 5370924 | Method for manufacturing transdermal devices A method for fabrication of multilayer transdermal drug release devices that divides the assembly of the various drug delivery components of the device into their unit operations; treats the prefabricated units as modules that are later combined to obtain... | 12/06/1994 |
| 5368571 | Electrochemical controlled dispensing assembly and method A pump assembly (20) employs electrochemistry to selectively control the delivery rate of a dispensing fluid (21) from a dispensing reservoir (24) by selectively controlling the flow rate of a driving fluid (19) from a driving reservoir (23) to a receivin... | 11/29/1994 |
| 5362496 | Method and therapeutic system for smoking cessation A method for treating conditions responsive to nicotine therapy, and particularly for smoking cessation therapy and for reducing nicotine craving, is described that utilizes transdermal nicotine delivery for obtaining base-line nicotine plasma levels coup... | 11/08/1994 |
| 5350581 | Method for manufacturing transdermal devices A method for fabrication of multilayer transdermal drug release devices that divides the assembly of the various drug delivery components of the device into their unit operations; treats the prefabricated units as modules that are later combined to obtain... | 09/27/1994 |
| 5338548 | Method for increasing the storage stability of physostigmine This patent relates a method for increasing the storage stability of physostigmine free base and physostigmine analogs by incorporating the free base into a polymer matrix. Chemically compatible enhancers and adjuvants do not interfere with the stabilizat... | 08/16/1994 |
| 5318540 | Controlled release infusion device A portable infusion device assembly, having two pouches in pressure transmitting relationship, the first containing infusate and the second, a driving medium. The driving medium is pressurized by activation of osmotic pump, electrochemical reaction, relea... | 06/07/1994 |
| 5290240 | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid An infusion pump assembly (20) is provided which employs electrochemistry to selectively control the delivery rate of a dispensing fluid (21) from a dispensing reservoir (24) by selectively controlling the flow rate of a driving fluid (19) from a driving ... | 03/01/1994 |
| 5135753 | Method and therapeutic system for smoking cessation A method for smoking cessation therapy is described that utilizes transdermal nicotine delivery for obtaining base-line coupled with buccal administration of nicotine to satisfy transient craving.... | 08/04/1992 |
| 4943435 | Prolonged activity nicotine patch A transdermal patch for delivering nicotine for prolonged periods of 12-24 hours. The patch includes a rate-controlling membrane or monolith to keep the nicotine flux within useful and safe limits. The patch is typically replaced once a day, and can be us... | 07/24/1990 |
| 4919939 | Periodontal disease treatment system A controlled release drug delivery system for placement in the periodontal pocket, gingival sulcus, tooth socket, wound or other cavity within the mouth. The system incorporates drug-containing microparticles in a fluid carrier medium, and is effective in... | 04/24/1990 |
| 4898582 | Portable infusion device assembly A portable infusion device assembly, having two side-by-side compartments, the first containing the drug or agent to be infused and an osmotic pump, and the second containing the driving liquid for the pump. The two chambers are separated during storage b... | 02/06/1990 |
| 4839174 | Novel transdermal nicotine patch A controlled release transdermal delivery system for nicotine administration. The system comprises an impermeable backing layer, a polyurethane matrix layer containing between about 5 wt % and 50 wt % nicotine, and an adhesive skin-contacting layer. The s... | 06/13/1989 |
