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| Number | Title | Issue Date |
| 6391414 | Structure and method for joining parts The invention relates to an article of manufacture comprising a partial or complete tubular primary part defining a tube axis and having an at least partially curved circumferential wall at least partially encircling the axis; said wall comprising a joint... | 05/21/2002 |
| 6371939 | Autoinjector An autoinjector for replaceable containers of syringe type, comprising a barrel of axially roughly constant cross-section, a front opening with or for an injection needle and at least one movable rear piston, optionally with a plunger connected thereto, i... | 04/16/2002 |
| 6368585 | Opthalmic compositions and methods Ophthalmic composition for use in ocular surgery comprises an aqueous solution of sodium hyaluronate with a concentration within the range of 18-40 mg sodium hyaluronate/ml solution and the molecular mass of sodium hyaluronate being in the range of 1×10 | 04/09/2002 |
| 6359001 | Use of -methyl-p-tyrosine to inhibit melanin production in iris melanocytes The use of agents for blocking the synthesis of tyrosinase to prevent permanent pigmentation of the iris caused by melanin deposit induced by pharmacological treatments or by metabolic imbalance is described.... | 03/19/2002 |
| 6331173 | Device for displacing a member in a container A multi-chamber ampoule comprises a container having at least one movable partition therein, the movable partition being adapted to sealingly isolate at least two substances to be mixed with each other, a seal or plunger movably disposed in the container,... | 12/18/2001 |
| 6328934 | Device for detection of when a test probe gets into contact with a liquid surface A device for detection of when at test probe of conducting material contacts a liquid surface includes a test probe of conducting material. The test probe is electrically screened by an insulated screen, with a part of the test probe projecting in front o... | 12/11/2001 |
| 6329383 | 2-amino-5-pyrimidine acetic acid compounds The present invention relates to new benzimidazole compounds with the following general structure (I): ##STR1## in which Y--X is >C.dbd.X when X is NR8, O, or S and R2 is H, alkyl, substituted alkylaryl or substituted aryl; or Y--X is >C--X when X is H, a... | 12/11/2001 |
| 6326476 | Heparin derivatives and process for the preparation thereof The invention relates to new heparin derivatives from bovine or porcine heparin which have a molecular weight equal to or larger than the standard heparin, show a sulfur content which is equal to or higher than that of the starting heparin or at least 13%... | 12/04/2001 |
| 6322813 | Compact member, method of manufacturing and use thereof The invention relates to a compact member comprising a plurality of porous cellulose matrices (PCMs), and providing extended release of an active compound located in the pores of said PCMs together with a release modifying agent. The friability of the com... | 11/27/2001 |
| 6313132 | Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, whe... | 11/06/2001 |
| 6310248 | Process and intermediates The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): ##STR1## wherein R1 | 10/30/2001 |
| 6306433 | Method of preparing pharmaceutical compositions The invention relates to a method of preparing a composition of lipid particles comprising a bioactive protein, capable of being subjected to high shear forces without substantial loss of activity, and a lipid agent. The characterizing features of the met... | 10/23/2001 |
| 6299601 | Arrangement in electronically controlled injection devices and method A device and method for administering one or more injections from an injection cartridge ensures that administration may be performed only if the device is oriented in a predetermined direction. The device features a holding device for the injection cartr... | 10/09/2001 |
| 6290680 | Prefilled ampoules and manufacture thereof A syringe type ampoule having a) a barrel with a front end and a rear end defining an axis therebetween, the barrel having substantially constant cross-section between the front end and the rear end, at least the front end ending in an opening, b) a seale... | 09/18/2001 |
| 6270479 | Autoinjector An autoinjector for replaceable containers of syringe type, comprising a barrel of axially roughly constant cross-section, a front opening with or for an injection needle and at least one movable rear piston, optionally with a plunger connected thereto, i... | 08/07/2001 |
| 6258798 | Method for treatment of unstable coronary artery disease by an early revascularisation together with administration of a low molecular weight heparin The invention relates to a method for treatment of unstable coronary artery disease, which is characterised by an early revascularisation together with administration of a low molecular weight heparin. Preferably the low molecular weight heparin is admini... | 07/10/2001 |
| 6251965 | Process for the modification of elastomers with surface interpenetrating polymer networks and elastomers formed therefrom A process for forming a surface modification on a polymer substrate and polymer substrates having such surface modifications. The process comprises the steps of absorbing a swelling monomer into the polymer substrate for a period of time in order to swell... | 06/26/2001 |
| 6238371 | Device for acclimatization to therapy by injections The present invention is directed to a cannula, attachable to an injection device comprising a needle entirely surrounded by an essentially cylindrical collapsible needle cover in order to visually hide the entire needle during the whole procedure of admi... | 05/29/2001 |
| 6221051 | Delivery device and method for its operation A preparation delivery device comprising a) a container for the preparation having or being prepared for the arrangement of an opening, b) a mechanism operable to deliver at least part of the preparation in the container through the opening, c) attachment... | 04/24/2001 |
| 6213977 | Limited depth penetration needle housing Disclosed are methods and means for facilitating injection which enable a correct penetration depth of the needle. These improvements are obtainable by using a needle covering device comprising an axially displaceable first tubular sleeve (30) arranged ar... | 04/10/2001 |
| 6180601 | Low molecular weight hyaluronic acid with peptide or protein The invention relates to freeze-dried soft, flexible and continous matrix of low-molecular weight hyaluronic acid or salt thereof, in which the molecular weight of the hyaluronic acid is preferably between 50 000 and 200 000 Da, containing at least one pe... | 01/30/2001 |
| 6126945 | Tumor killing effects of enterotoxins, superantigens, and related compounds Staphylococcal enterotoxins obtained by secretion from Staphylococcus aureus, by expression of enterotoxins in other bacteria or cells, or by chemical mutagenic treatment of Staphlococcus aureus strains are used in treatment of cancer as tumoricidal agent... | 10/03/2000 |
| 6090596 | Method and means for the production of hyaluronic acid Supercapsulated strains of group A and C streptococci are provided. The strains are used in the production of hyaluronic acid with a molecular weight exceeding 6 million.... | 07/18/2000 |
| 5873856 | Limited depth penetration needle housing Disclosed are methods and means for facilitating injection which enable a correct penetration depth of the needle. These improvements are obtainable by using a needle covering device comprising an axially displaceable first tubular sleeve (30) arranged ar... | 02/23/1999 |
| 5776947 | Use of quinoline-3-carboxamide compounds for inhibiting the production of tumor necrosis factor (TNF) and/or for the treatment of septic shock The use of a quinoline-3-carboxamide compound comprising structure (I), optionally with substituents for the hydrogen atoms shown (H1-9), and a salt of compound (I) where (a) ---- represents that there are two conjugated double bonds between th... | 07/07/1998 |
| 5772630 | Injection cartridges An injection cartridge is disclosed which has provision for the after injection of a rinsing solution to wash off the medicament that is first injected. The novel cartridge has a forward compartment and a rearward compartment, each having a piston dispose... | 06/30/1998 |
| 5753518 | Method of determining affinity and kinetic properties A method of determining the affinity and kinetic properties of low molecular weight ligands for their interaction with a common receptor comprises the steps of immobilizing the receptor on a sensing structure, mixing in known proportions each ligand with ... | 05/19/1998 |
| 5712260 | Estramustine formulations with improved pharmaceutical properties The present invention provides a pharmaceutical composition comprising an estramustine derivative and a cyclodextrin, particularly in the manufacture of a medicament suitable for the oral administration of an estramustine derivative to a patient suffering... | 01/27/1998 |
| 5686464 | 3,3-diphenylpropylamines, their use and preparation A 3,3-diphenylpropylamine of the formula I, or its physiologically acceptable acid salt thereof: ##STR1## wherein R1 represents hydrogen or methyl, R2 and R3 independently represent hydrogen, methyl, methoxy, hydroxy,... | 11/11/1997 |
| 5658910 | Nicotinic acid esters Novel compounds of the formula: ##STR1## wherein R is selected from saturated or unsaturated alkyls, saturated or unsaturated cycloalkyls, heterocyclic compounds, or from (a) or (b) wherein G is carbon wherein G is carbon or nitrogen; m is 0-10, wher... | 08/19/1997 |
| 5599937 | Heteroaromatic quinuclidinenes, their use and preparation The invention relates to novel compounds of general formula (I), wherein R is a group of general formula (II) or (III), where X1 represents oxygen or sulphur and Y1 and Z1 both represent carbon, or X1 represents... | 02/04/1997 |
| 5594005 | Use of quinoline-3-carboxamide compounds for treatment of diabetes Quinoline-3-carboxamide compounds of formula (I) are effective in preventing, treating or ameliorating Type I diabetes. ##STR1## wherein ----- represents two conjugated double bonds between the atoms comprised by the dashed line, X1 and X | 01/14/1997 |
| 5565455 | Method for treating substance abuse disorders A method for relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse and/or for the suppression of dependence on drugs or substances of abuse which comprises administering to a patient in need thereof an effe... | 10/15/1996 |
| 5559269 | 3,3-diphenylpropylamines, their use and preparation The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represe... | 09/24/1996 |
| 5549669 | Intraocular lens having haptics with non-symmetrical cross-section An intraocular lens includes an optical lens body and haptics extending outwardly from the optical lens body. Each of the haptics is defined by a plane and includes at least a portion having a cross-section which is non-symmetrical with respect to the pla... | 08/27/1996 |
| 5527821 | Pharmacologically active alpha-[tertiary-aminomethyl]-benzenemethanol derivatives | 06/18/1996 |
| 5525593 | Medicinal use of IFG-II The use of IGF-II for preparing a medicament for the regeneration of muscle tissue; and methods for medical treatment for the purpose of regenerating muscle tissue, for minimizing scar formation during healing of a wound or for preventing undesired tissue... | 06/11/1996 |
| 5504092 | Use of Linomide to increase hemopoietic cell precursors The present invention concerns the use of Linomide, i.e. N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxa mide for the treatment of humans subjected to BMT, cytostatic treatment irradiations or combinations thereof.... | 04/02/1996 |
| 5501673 | Injection cartridge An injection cartridge of the dual-chamber type has a bypass connection between its two chambers which is arranged such that the interior wall of the cartridge is modified in a determined area in such a way that the movable wall between the two chambers d... | 03/26/1996 |
| 5335678 | Smoking composition The invention is comprised of a smoking composition of nicotine in the form of an inclusion complex located between crylisized polysaccharide and nicotine and a smoking material. The composition releases nicotine when exposed to elevated temperatures.... | 08/09/1994 |
