Assignee: Pharmachemie B.V.

Location: Haarlem, NL
No. of patents: 19

Number	Title	Issue Date
7430842	Protected vial, and method for manufacturing same For the prevention of contamination of a vial with traces of medicinal fluids, for example cytostatics and antibiotics, which may be spilt on the outside of the vial while filling, the vial is provided with a tight-fitting protective envelope, preferably made of a t...	10/07/2008
6613767	Stable aqueous folinate solution A stable aqueous solution of folinic acid of up to about 400 mg/ml, which does not crystallize at refridgeration temperatures, is obtained by preparing an aqueous solution of sodium folinate....	09/02/2003
6407265	Tin polyoxaalkanecarboxylates and compositions containing them Tin polyaalkanecarboxylates having the formula [(R1p R2q Sn)r Os ]t wherein R1 represents C1 -C6 alkyl, branched or straight, substituted or not by on...	06/18/2002
6344571	Water soluble analogs and prodrugs of paclitaxel The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R1 =C(O)CH2 CH(OH)COOX, R2 =H, C(O)CH2 CH(OH)COOX, X=H, Li, Na or any other pharmaceutically acceptable counterion, a...	02/05/2002
6225463	Synthesis of new ଲ-lactams The object of the present invention is the development of new chiral auxiliaries for improved ଲ-lactam formation that control both the diastereoselectivity of ଲ-lactam formation and which can be removed without destruction of the sensitive aze...	05/01/2001
5874595	Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III 10-Deacetylbaccatin III is selectively acylated to baccatin III and derivatives thereof in high yield with anhydrides (e.g. acetic anhydride), catalysed by Lewis acids. Extremely effective catalysts in this reaction are compounds of the formula MLx	02/23/1999
5874550	Process for preparing epirubicin or acid addition salts thereof from daunorubicin This invention relates to a novel method for the chemical preparation of epirubicin or acid addition salts thereof, in particular the HCl salt, from daunorubicin. This process avoids the disadvantages of the prior art. First daunorubicin is methanolized t...	02/23/1999
5760072	Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy A paclitaxel prodrug has a paclitaxel portion coupled to a cleavable N-(aliphatic or aromatic)-O-glycosyl carbamate spacer group, and can be administered orally, topically or by injection to provide an anti-tumor effect, the prodrug being activated by a h...	06/02/1998
5710135	Anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula ##STR1## as well as the acid addition salts thereof. Further the synt...	01/20/1998
5583157	Dibutyltin bis(dihydroxybenzoates) and compositions containing these compounds This invention provides novel Sn compounds, i.e. di-n.butyltindihydroxybenzoates, which exhibit excellent activities against varies tumors. This invention also provides pharmaceutical compositions which contain said novel Sn compounds in combination with ...	12/10/1996
5559147	Aromatic fluorine-containing organotin compounds and anti-tumour composition The invention relates to novel aromatic fluorine-containing organotin compounds of the formula {(F5 C6 RCO2 SnBu2)2 O}2 and {(F5 C6 RCO2)2 SnBu2	09/24/1996
5382597	Organo-tin compounds having anti-tumour activity and anti-tumour compositions The invention relates to anti-tumor compositions containing as an active ingredient one or more compounds of the formula Ar3 Sn--O--C(O)--C6 H2 XYZ wherein X and Y are each H, OH, halogen or alkyl; and Z is halogen, amino, alko...	01/17/1995
5320095	Device for use with the inhalation of powdered materials contained in rod-shaped capsules The invention relates to a device for use with the inhalation of powdered materials contained in rod-shaped capsules, having two parts (2, 3) which may be pivoted one relative to the other, and provided with a mixing chamber (7) having substantially tange...	06/14/1994
5294701	Anthracycline compounds and intermediates This invention provides novel anti-tumour compounds of the formula ##STR1## wherein R1 and R2 are hydrogen or together form an alkyl-, alkoxy- or OH-substituted aromatic group, which optionally contains an N atom as a hetero-ato...	03/15/1994
5183913	Cyclic triketone compounds and trimethylsilyoxy butadiene compounds and their use in the preparation of daunomycinone derivatives The invention provides novel cyclic triketone compounds of the formulae ##STR1## wherein S is H, alkyl or alkoxy and R* is a group of the formule ##STR2## wherein R1 is methyl and R2 is an alkyl group containing at least 2 ...	02/02/1993
5177076	Aqueous folinate solution stable at refrigerator temperature, as well as process for its preparation An aqueous folinate solution stable at refrigerator temperature is provided which contains folinate ions, complexed calcium ions, and if desired free calcium ions in a total amount of more than 12 mg/ml, as well as anions of a complexing agent for calcium...	01/05/1993
5104896	Carboplatin composition A carboplatin composition is provided in the form of an aqueous solution of carboplatin buffered at a pH of 2-6.5. Such a ready to use solution possesses a remarkable stability....	04/14/1992
5097051	Cyclic triketone compounds and trimethylsilyloxy butadiene compounds and their use in the preparation of daunomycinone derivatives The invention provides novel cyclic triketone compounds of the formulae ##STR1## wherein S is H, alkyl or alkoxy and R* is a group of the formule ##STR2## wherein R1 is methyl and R2 is an alkyl group containing at least 2 ...	03/17/1992
5079349	Trimethylsilyl acetylene compounds, their preparation and their use in the preparation of daunomycinone derivatives The invention relates to novel compounds of the formulae ##STR1## wherein S is H, alkyl or alkoxy and R is a good leaving group, and to the preparation of these compounds in a stereospecific manner to obtain a configuration wherein OH at C-3 and OR a...	01/07/1992

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Assignee: Pharmachemie B.V.