Assignee: Pfizer Inc.

Location: New York, NY
No. of patents: 575

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Number	Title	Issue Date
6776908	Micro-equilibrium dialysis vertically-loaded apparatus An improved device for equilibrium dialysis procedures utilizing a dialysis membrane inserted in a gap in and separating all of any number of test wells contained in the dialysis block into at least a donating and receiving side which can be accessed and manipulated...	08/17/2004
6777393	4″-substituted-9-deoxo-9a-aza-9a homoerythromycin a derivative The invention relates to a method of preparing compounds of the formula and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial an...	08/17/2004
6777424	Methods for treating osteoarthritis using an estrogen agonist / antagonist The present invention provides methods and kits for treating osteoarthritis using an estrogen agonist/antagonist. ...	08/17/2004
6770645	Pharmaceutically active compounds Compound of general formula I: wherein R1, R2, R3, R4, X, Y and R5 have the meanings given herein which are useful in the curative and prophylactic treatment of a me...	08/03/2004
6767558	Inhibiting oxidative degradation of pharmaceutical formulations The invention provides methods for inhibiting oxidative degradation of pharmaceutical formulations comprising at least one oxidation-susceptible active drug ingredient which methods comprise adding an oxidation-inhibiting amount of a ferrous ion source, preferably i...	07/27/2004
6764676	Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus The present invention is directed to a novel strain of feline immunodeficiency virus, designated herein as FIV-141, and to attenuated forms of the virus produced by mutating specific regions of the viral genome. The virus and mutated forms of the virus may be used t...	07/20/2004
6764993	Use of o-vanillin and o-vanillin/trolox combinations The invention provides methods of protecting solid-state proteins from the effects of ionizing radiation which comprise combining the protein with a radiation-protecting amount of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde; radiation-pr...	07/20/2004
6763607	Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid disper...	07/20/2004
6765023	Use of substituted N, N-disubstituted reverse aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle...	07/20/2004
6759534	Process and intermediates for pyridazinone antidiabetic agents The present invention relates to a process for preparing pyridazinone aldose reductase inhibitors which are useful in the prevention and/or treatment of diabetic complications such as diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cardiomy...	07/06/2004
6759393	Growth hormone and growth hormone releasing hormone compositions The present invention relates to methods and compositions of growth hormone and/or growth hormone releasing hormone that promote of the release and the elevation of growth hormone when administered to animals. The present invention further relates to methods and com...	07/06/2004
6756401	Compositions and methods for treating osteoporosis and lowering cholesterol This invention relates to methods, pharmaceutical compositions and kits useful in promoting bone formation and/or preventing bone loss and lowering blood cholesterol. The compositions are comprised of an estrogen agonist/antagonist as a first active component and a ...	06/29/2004
6756385	Imidazole derivatives The invention provides compounds of formula 1 wherein R1, R2, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to ha...	06/29/2004
6756388	Benzothiophenes and related compounds as estrogen agonists The invention is a compound of Formula (I): wherein R is —OH, R1 is —OH, R2 is —H, n is 2 or 3 and X is sulfur, or a pharmaceutically acceptable salt ...	06/29/2004
6756373	Pharmaceutically active compounds There is provided a compound of formula I: wherein X represents O or NR5 R4 represents H, halo, cyano, nitro, halo(loweralkyl), OR6, OC(O)R7, C(O)R8, ...	06/29/2004
6753332	Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents The present invention relates to compounds of the formula wherein R1, R3, R5 and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicin...	06/22/2004
6753334	Preparation of sodium-hydrogen exchanger type-1 inhibitors This invention relates to methods of preparing sodium-hydrogen exchanger type 1 (NHE-1) inhibitors of formula I′ intermediates of the NHE-1 inhibitors and a new almost colorless form of the NHE-1 inhibitor N-(5-cyclopro...	06/22/2004
6750363	Olefination process to itaconate and succinate derivatives An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. wh...	06/15/2004
6747054	EP4 receptor selective agonists in the treatment of osteoporosis This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula I, wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutical compo...	06/08/2004
6746856	Microbial conversion of bicyclic heteroaromatic compounds The present invention relates to processes for the microbial oxidation of bicyclic heteroaromatic compounds which comprise contacting these compounds with a microorganism, or a suitable mutant thereof, and incubating the resulting mixture under conditions sufficient...	06/08/2004
6743799	Use of PDE V inhibitors for improved fecundity in mammals The invention relates to the use of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase type five (cGMP PDE V) inhibitor for increasing fecundity in a mammal by one or more of (a) promoting the growth of an oocyte, zygote, blastocyst, embryo and/or foetus, ...	06/01/2004
6743921	Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-y...	06/01/2004
RE38524	Dipeptide derivatives as growth hormone secretagogues This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the lev...	06/01/2004
6737430	Mutual prodrug of amlodipine and atorvastatin The present invention relates to a mutual prodrug of amlodipine and atorvastatin, pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions thereof and the use of said prodrug and its salts in the manufacture of medicaments for the treatme...	05/18/2004
6737437	EP4 receptor selective agonists in the treatment of osteoporosis This invention is directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteo...	05/18/2004
6733754	Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal. ...	05/11/2004
6734306	N-benzenesulfonyl L-proline compounds as bradykinin antagonists This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein X1 and X2 are halo; R1 and R2 are independently hydrogen or C	05/11/2004
6734175	Treatments for obesity and methods for identifiying compounds useful for treating obesity The present invention provides a method of treating obesity, sexual dysfunction (including erectile dysfunction), diabetes, insulin resistance, hyperinsulinemia, Syndrome X, adrenal dysfunction, hypertension, hypercholesterolemia, atherosclerosis, hyperlipoproteinem...	05/11/2004
6734303	Process for the production of quinazolines The invention provides a process for the production of a compound of formula (A) or a pharmaceutically acceptable salt or solvate thereof: which comprises condensing a compound of formula (B)	05/11/2004
6734186	Compounds for the treatment of female sexual dysfunction A method of treating a female suffering from FSD, in particular FSAD, is described. The method comprises delivering to the female an agent that is capable of potentiating cAMP in the sexual genitalia; wherein the agent is in an amount to cause potentiation of cAMP i...	05/11/2004
6727238	Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi...	04/27/2004
6727283	Sertraline oral concentrate The present invention provides an essentially nonaqueous, liquid pharmaceutical concentrate composition for oral administration containing sertraline or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients. The present in...	04/27/2004
6727352	Methods of making macrolides This invention relates to methods of preparing a compound of Formulae 2, 5 and 7, wherein R2-R5, R7, R9, R10 and R15 are defined herein. ...	04/27/2004
6727392	Process for the preparation of non-steroidal glucocorticoid receptor modulators A process for preparing a compound of the formula useful as a non-steroidal glucocorticoid receptor modulator. ...	04/27/2004
6723744	Indole carboxylic acids as thyroid receptor ligands A compound of the formula wherein W, R1, R2, R3, R4, R5, R6, R7, R8 and R13 are as defined herein, useful in the treatmen...	04/20/2004
6720427	Thiazole derivatives The invention provides compounds of formula 1 wherein R1, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inh...	04/13/2004
6720330	Somatostatin antagonists and agonists that act at the SST subtype 2 receptor Compounds according to the formula A—Z—W as herein described, wherein A is selected from the groups consisting of: A′—(CH2)n—, A′—(CH2)nSO2—, and A′—(CH2)nCO—, where n...	04/13/2004
6720336	4,4-biarylpiperidine derivatives The present invention relates to compounds of the formula I, wherein Z1, Z2, R1, R2 and R3 are defined as in the specification, pharmaceutical compositions containin...	04/13/2004
6720351	Triamide-substituted heterobicyclic compounds The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for p...	04/13/2004
6716861	3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors Compounds of formula (I): wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP. ...	04/06/2004

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Assignee: Pfizer Inc.