Assignee: Pfizer Inc.

Location: New York, NY
No. of patents: 575

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Number	Title	Issue Date
8183238	Bicyclic and tricyclic compounds as KAT II inhibitors Compounds of Formula X: wherein A, X, Y, Z, R5, R6a, and R6b are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive defi...	05/22/2012
8183230	Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms The present invention is directed to pharmaceutical compositions containing a therapeutically effective amount of an Active Pharmaceutical Ingredient (“API”), a pharmaceutically acceptable cyclodextrin and a pharmaceutically acceptable preservative. The inventio...	05/22/2012
8178699	Modulators of CCR9 receptor and methods of use thereof Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated with modul...	05/15/2012
8178574	Tosylate salt of trans-N-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-yl-methyl)-phenyl] cyclobut anecarboxamide The present invention is directed to the tosylate salt of trans-N-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)-phenyl]-cyclobutanecarboxamide Formula (I): to solvates (e.g., hydrates) thereof, to polymorphs there...	05/15/2012
8178558	Substituted pyridylmethyl bicycliccarboxyamide compounds This invention relates to novel substituted pyridylmethyl bicyclocarboxamide compounds and to their use in therapy. These compounds are particularly useful as modulators of the VR1 (Type I Vanilloid) receptor, and are thus useful for the treatment of pain, neuralgia...	05/15/2012
8163280	Antibodies to c-Met The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and ant...	04/24/2012
8158673	Histamine-3 receptor antagonists This invention is directed to a compound of formula I, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a process of preparation of a compoun...	04/17/2012
8158660	Tricyclic compounds, compositions and methods The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated ...	04/17/2012
8158650	Substituted phenylmethyl bicyclocarboxyamide compounds This invention provides a compound of the formula (I). These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comp...	04/17/2012
8148409	Phenathrenone compounds, compositons and methods The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated ...	04/03/2012
8148401	Benzimidazole derivatives The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are...	04/03/2012
8148340	Immunomodulatory oligonucleotides Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are...	04/03/2012
8148331	Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities thereof. In particular, the present invention is directed to (1) a recomb...	04/03/2012
8143379	Human monoclonal antibodies to CTLA-4 In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, ...	03/27/2012
8138188	Melanocortin type 4 receptor agonist piperidinoylpyrrolidines The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in ...	03/20/2012
8138177	Benzimidazolone derivatives as CB2 receptor ligands This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds and the use of such compounds...	03/20/2012
8134007	Pyridine derivatives The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such c...	03/13/2012
8134004	Substituted N-bicyclicalkyl bicycliccarboxyamide compounds This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the ab...	03/13/2012
8133899	Pyrrolo[2,3-]pyrimidine compounds Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds. ...	03/13/2012
8133883	Compositions containing piperacillin and tazobactam useful for injection An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and option...	03/13/2012
8128937	N protein mutants of porcine reproductive and respiratory syndrome virus The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified virus and polynucleotides are also provided. ...	03/06/2012
8124639	Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their...	02/28/2012
8119624	Fused phenyl amido heterocyclic compounds The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from...	02/21/2012
8114871	3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined above. The invention...	02/14/2012
8106197	Aminoheteroaryl compounds as protein kinase inhibitors Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET. ...	01/31/2012
8097733	Pyrazole derivatives as 5-LO-inhibitors The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same. ...	01/17/2012
8097621	Pyrazolo[4,3-d]pyrimidines as phosphodiesterase inhibitors This invention relates to compounds of formula (I) ...	01/17/2012
8093400	Compounds useful in therapy The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y′ are as defined herein, and pharmaceutical compositions compris...	01/10/2012
8088804	N-hydroxyamide derivatives possessing antibacterial activity Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formu...	01/03/2012
8084488	*Forms of [R-(R,R)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium* Novel forms of atorvastatin magnesium salt designated Form A, Form B, Form C, Form D, Form E, and Form F, pharmaceutical compositions containing such compounds, methods for their preparation and methods utilizing the compounds for treatment of hyperlipidemia, hyperc...	12/27/2011
8080646	Human monoclonal antibodies to activin receptor-like kinase-1 The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathw...	12/20/2011
8080580	Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives Compounds of Formula (I) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by sodium-glucose transporter inhibitors (in particular, SGLT2 inhibitors). ...	12/20/2011
8080556	2-amino pyrimidine compounds as potent HSP-90 inhibitors The present invention is directed to compounds of formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors. ...	12/20/2011
8080243	Isolated antibody which specifically binds to PCSK9 The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The i...	12/20/2011
8076356	Triazolopyridinylsulfanyl derivatives as P38 map kinase inhibitors A compound of formula (I), or a pharmaceutical acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p3...	12/13/2011
8071606	Substituted pyrazinone amides useful for activation of glucokinase The present invention provides compounds of Formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. The variab...	12/06/2011
8067594	Process for the production of benzopyran-2-ol derivatives The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; compris...	11/29/2011
8067591	Pyrrolopyrazole, potent kinase inhibitors Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. ...	11/29/2011
8063044	Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation ther...	11/22/2011
8044227	Preparation of pregabalin and related compounds Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. ...	10/25/2011

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Assignee: Pfizer Inc.