Assignee: Parker Hughes Institute

Location: Roseville, MN
No. of patents: 49

Number	Title	Issue Date
7186736	NNI for treatment of multi-drug resistant HIV The present invention is directed to compounds and methods suitable for the treatment of HIV infection. ...	03/06/2007
7144874	Aryl phosphate derivatives of d4T having activity against resistant HIV strains Methods of inhibiting virus replication of in a cell infected with a resistant strain of HIV that includes administering to the infected cell a virus replication inhibiting amount of an aryl phosphate derivative of d4T. ...	12/05/2006
7071176	Aryl phosphate derivatives of AZT having anti-HIV activity Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase....	07/04/2006
7037937	Cytotoxic compounds Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular proliferation, for example, as effective anti-cancer agents. The com...	05/02/2006
7038049	Haloanilino quinazolines and therapeutic use thereof The present disclosure includes compounds, for example a compound according to formula I or a pharmaceutically acceptable salt thereof. The compounds of the present disclosure are useful in methods of treating cancerous...	05/02/2006
6960606	Adamantyl Thiazole Thioureas Novel aromatic and heterocyclic thiazolyl thiourea compounds, pharameutical compositions including such, and methods for their use are disclosed. The compounds are effective agents for the treatment of HIV infection, including non-nucleoside inhibitor-resistant, and...	11/01/2005
6958359	Vanadium compounds as anti-angiogenic agents Vanadium compounds for inhibiting angiogenesis useful for treating or preventing diabetic retinopathy, hemangiomas, cancers with abnormal blood vessel supply, restenosis following vascular injury, and the like. ...	10/25/2005
6953875	Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders A transgenic zebrafish animal model is disclosed. The model can be used for study of hematopoetic cell differentiation, control, and screening of therapeutic agents and can include a transgenic zebrafish expressing a heterologous Ikaros protein. ...	10/11/2005
6933300	JAK-3 inhibitors for treating allergic disorders Inhibitors of JAK3 kinase for the treatment of allergy, and others are described. ...	08/23/2005
6878388	Vanadium compounds for treating proliferative cell disorders Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue. ...	04/12/2005
6774139	Dual function microbicides Contraceptive activity as well as anti-microbial, particularly anti-viral protection is provided by contraceptive compositions containing a thiourea compound of the invention exhibiting spermicidal or sperm-immobilizing activity. Preferred compounds of the invention...	08/10/2004
6734207	Cytotoxic compounds Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular proliferation, for example, as effective anti-cancer agents. The com...	05/11/2004
6727265	Phenoxyethyl-thiourea-pyridine compounds and their use for treatment of HIV-infections The invention provides compounds which inhibit reverse transcriptase (RT) and which inhibit replication of a retrovirus, such as human immunodeficiency virus-1 (HIV-1). The compound of the invention are phenoxyethyl-thiourea-pyridines. The invention additionally pro...	04/27/2004
6689793	Piperidinylethyl-, phenoxyethyl-, and ଲ-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity The present invention is directed to derivatives of piperidinylethyl, phenoxyethyl, and fluorophenethyl bromopyridyl thioureas, which have been found to be effective non-nucleoside inhibitors (NNRTI) of NNI-resistant and multi-drug resistant human immunod...	02/10/2004
6642221	Vanadium compounds as anti-proliferative agents Vanadium compounds as anti-proliferative agents. These compounds act to disrupt mitotic and meiotic spindle formation and thus are useful to prevent cell mitosis (proliferation) and meiosis....	11/04/2003
6552027	Quinazolines for treating brain tumor Novel substituted quinozaline compounds and conjugates useful to inhibit the growth of brain tumor cells and to inhibit adhesion and migration of brain tumor cells. The compounds of the invention include 4-(3'-bromo-4'-hydroxy phenyl)-amino-6,7-dimethoxyq...	04/22/2003
6545152	R-isomers of nonnucleoside inhibitors Novel chiral derivitaves of non-nucleoside inhibitors (NNI), particularly R-isomers of halopyridyl and thiazoyl thiourea compounds are provided as potent inhibitors of reverse transcriptase (RT), and particularly of retroviral RT, most particularly HIV RT...	04/08/2003
6528495	Aryl phosphate derivatives of d4T having anti-HIV activity Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse tra...	03/04/2003
6512003	Synthetic spiroketal pyranes as potent anti-cancer agents and use Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The c...	01/28/2003
6503890	Aryl phosphate derivatives of d4T having anti-HIV activity Aryl phosphate nucleoside derivatives show potent activity against HIV without undesirable levels of cytotoxic activity. Examples of aryl phosphate nucleoside derivatives include aryl phosphate derivatives of d4T with para-bromo substitution on the aryl g...	01/07/2003
6495556	Dimethoxy quinazolines for treating diabetes The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the presen...	12/17/2002
6482828	4-(4'-hydroxyphenyl) amino-6,7-dimethoxyquinazoline to prevent development of colorectal cancer The present invention is directed to a method of preventing the development or recurrence of colorectal cancer in a mammal comprising administering to the mammal, an effective cancer preventative amount of 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoli...	11/19/2002
6482815	Organic-arsenic compounds Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells....	11/19/2002
6482816	Organic arsenic compounds Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells....	11/19/2002
6452005	JAK-3 inhibitors for treating allergic disorders Inhibitors of JAK3 kinase for the treatment of allergy inhibit mast cell degranulation an dmediator release....	09/17/2002
6407078	AZT derivatives exhibiting spermicidal and anti-viral activity Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient conta...	06/18/2002
6391921	Treatment of inflammation with 2,4,6-trihydroxy-଱-para-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 2,4,6-trihydroxy-଱-p-methoxyphenylacetophenone (also identified herein as "D-58"), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or p...	05/21/2002
6376504	Phenethyl-5-bromopyridlythiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DBABO) derivatives exhibiting spermicidal activity Novel phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity as well as anti-viral activity. These novel compounds can be incorporated within contraceptive compositions to provide for...	04/23/2002
6355678	Inhibitors of the EGF-receptor tyrosine kinase and methods for their use Novel compounds and pharmaceutical compositions useful as EGFR tyrosine kinase inhibitors. Methods of the invention include administration of the EGFR TK inhibitors to treat diseases characterized by enhanced expression of EGF, including cancers, particul...	03/12/2002
6350736	Aryl phosphate derivatives of d4T having anti-HIV activity Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse tra...	02/26/2002
6335364	Synthetic spiroketal pyranes as potent anti-cancer agents Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The c...	01/01/2002
6329420	Tubulin binding compounds (COBRA) Novel tubulin binding compounds having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds a...	12/11/2001
6326373	JAK-3 inhibitors for treating allergic disorders Inhibitors of JAK3 kinase for the treatment of allergy inhibit mast cell degranulation an dmediator release....	12/04/2001
6319947	Vanadium (IV) metallocene complexes having spermicidal activity Novel spermicidal compounds which are organometallic cyclopentadienyl metal complexes, particularly vanadium IV complexes, are described including corresponding contraceptive and therapeutic compositions and method for providing contraception and selectiv...	11/20/2001
6316454	6,7-Dimethoxy-4-anilinoquinazolines 6,7-Dimethoxy-4-anilinoquinaozolines of the formula: ##STR1## or pharmaceutically acceptable acid addition salts thereof are disclosed. These novel compounds are useful for inducing apoptosis and preventing metastases of brain tumor cells....	11/13/2001
6313130	JAK-3 inhibitors for treating allergic disorders Inhibitors of JAK3 kinase for the treatment of allergy inhibit mast cell degranulation an dmediator release....	11/06/2001
6300351	Beta-fluoroethyl thiourea compounds and use Novel compounds that are potent inhibitors of HIV reverse transcriptase (RT) are described in the invention. These novel compounds also inhibit replication of a retrovirus, such as human immunodeficiency virus-1 (HIV-1). The novel compounds of the inventi...	10/09/2001
6294575	BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors....	09/25/2001
6262053	Melamine derivatives as potent anti-cancer agents Novel pharmaceutical compositions including melamine derivatives and methods for the treatment of cancer including prostate, brain, breast, and leukemia are described. The methods are directed to administering a therapeutically effective amount of a pharm...	07/17/2001
6258841	Tubulin binding compounds (COBRA) Novel tubulin binding compounds having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds a...	07/10/2001

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Assignee: Parker Hughes Institute