Assignee: Palatin Technologies, Inc.

Location: Cranbury, NJ
No. of patents: 38

Number	Title	Issue Date
8114844	Linear and cyclic melanocortin receptor-specific peptidomimetics Linear and cyclic peptidomimetics which bind to one or more melanocortin receptors are provided, which peptidomimetics include at least one ring-constrained amino acid surrogate of formula I: where R1, R2	02/14/2012
7968548	Melanocortin receptor-specific piperazine compounds with diamine groups Melanocortin receptor-specific compounds with diamine groups of the general formula and pharmaceutically acceptable salts thereof, where W is a diamine heteroatom unit with at least one cationic center, hydrogen bond donor ...	06/28/2011
7964601	Melanocortin receptor-specific compounds A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are a...	06/21/2011
7964181	Amino acid surrogates for peptidic constructs Ring-constrained amino acid surrogates of formula I: where R1, R2, R3, R4, R5, R6a, R6b, R7, and y are as defined in the specification,...	06/21/2011
7897721	Cyclic peptide compositions for treatment of sexual dysfunction A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and p are as defined. Further pr...	03/01/2011
7834017	Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents There is provided compounds having the formula of structure I: wherein the groups —C(R8)(CH2)vCH(R9)(CH2)y-Q and —C(R8)(CH2)v	11/16/2010
7807678	Peptidomimetics of biologically active metallopeptides The invention relates to a method of deriving a peptidomimetic of a biologically active metallopeptide, wherein the peptidomimetic includes at least one non-peptide ring structure defining a template space superimposable on a corresponding defined template space of ...	10/05/2010
7795378	Peptide compositions for treatment of sexual dysfunction A peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and n are as defined. Further provided ...	09/14/2010
7795221	Linear natriuretic peptide constructs Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z...	09/14/2010
7754691	Linear melanocortin receptor-specific peptides for cachexia Linear peptides with a C-terminus —OH group that are specific for one or more melanocortin receptors, and which may be used in the treatment of melanocortin receptor-mediated disorders, including a variety of body weight disorders including cachexia, and for treat...	07/13/2010
7732451	Naphthalene-containing melanocortin receptor-specific small molecule A method of modulating energy homeostasis in a mammal without eliciting a sexual response by administration of a therapeutically effective amount of a pharmaceutical composition including a melanocortin receptor compound of the formula:	06/08/2010
7727991	Substituted melanocortin receptor-specific single acyl piperazine compounds Melanocortin receptor-specific compounds of the general formula and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, W is a heteroatom unit with at ...	06/01/2010
7727990	Melanocortin receptor-specific piperazine and keto-piperazine compounds Melanocortin receptor-specific compounds of the general formula and pharmaceutically acceptable salts thereof, where X, W, J, Q, L1, L2, L3, R1a, R1b, R2a, a...	06/01/2010
7718802	Substituted melanocortin receptor-specific piperazine compounds Melanocortin receptor-specific compounds of the general formulas and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, L is a linker, W is a heteroat...	05/18/2010
7709484	Substituted melanocortin receptor-specific piperazine compounds A substituted piperazine compound having the structure I: or the structure IX: or an enantomeric, stereoisomeric or diastereomeric form of the foregoing, and pharmaceutically acce...	05/04/2010
7655658	Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds A thienopyrimidine compound of the formula: wherein R1, R2, R3, and R4 are as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-assoc...	02/02/2010
7622440	Cyclic natriuretic peptide constructs Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J...	11/24/2009
7601753	Pyrrolidine melanocortin-specific compounds Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in the specif...	10/13/2009
7550602	Small molecule compositions for sexual dysfunction Compounds of the general formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and X are as defined. Further provided are methods for treatment of sexual dysfunction, i...	06/23/2009
7473760	Cyclic peptide compositions for treatment of sexual dysfunction A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6, m, n and p are as defined. Further provided are c...	01/06/2009
7456184	Melanocortin receptor-specific compounds A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are a...	11/25/2008
7425608	Method of making metallopeptides Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at leas...	09/16/2008
7417027	Linear and cyclic melanocortin receptor-specific peptides Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity. In one embodiment, a linear peptide of the following general formula is provided:	08/26/2008
7396814	Metallopeptide compositions for treatment of sexual dysfunction Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid...	07/08/2008
7385025	Metallopeptide compounds Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each availab...	06/10/2008
7354923	Piperazine melanocortin-specific compounds Melanocortin receptor-specific piperazine or ketopiperazine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where X is CH2 or C═O, R1, R2, a...	04/08/2008
7351690	Knockout identification of target-specific sites in peptides The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary structure within a known parent polypeptide that binds to the target of inte...	04/01/2008
7345144	Cyclic peptides for treatment of cachexia A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the spec...	03/18/2008
7342089	Cyclic peptides for treatment for cachexia A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z ...	03/11/2008
7307063	Melanocortin metallopeptides for treatment of sexual dysfunction Metallopeptides are provided for use in treatment of sexual dysfunction in mammals. The metallopeptides are agonists for at least one of melanocortin-3 or melanocortin-4 receptors. The metallopeptides are conformationally fixed on complexation of a metal ion-binding...	12/11/2007
7235625	Multiple agent therapy for sexual dysfunction Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose mean...	06/26/2007
7189755	Pyrrolidine melanocortin-specific compounds Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in...	03/13/2007
7176279	Cyclic peptide compositions and methods for treatment of sexual dysfunction A cyclic peptide with a C-terminus —OH group. Further provided are compositions and methods for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cycli...	02/13/2007
7097824	Tuftsin metallopeptide analogs and uses thereof Tuftsin receptor-specific peptides, peptidomimetics and peptide-like constructs are provided, particularly for use in biological, pharmaceutical and radiopharmaceutical applications, in which the peptide, peptidomimetic or construct is conformationally fixed on comp...	08/29/2006
7049398	Melanocortin metallopeptide constructs, combinatorial libraries and applications Metallopeptides and metallopeptide combinatorial libraries specific for melanocortin receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and pep...	05/23/2006
6979436	Opioid metallopeptide compositions and methods Metallopeptides and metallopeptide combinatorial libraries specific for opioids receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-...	12/27/2005
6794489	Compositions and methods for treatment of sexual dysfunction Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle...	09/21/2004
6579968	Compositions and methods for treatment of sexual dysfunction Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequ...	06/17/2003

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Assignee: Palatin Technologies, Inc.