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| Number | Title | Issue Date |
| 6492490 | Liquid phase peptide syntheses of KL-4 pulmonary surfactant The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process... | 12/10/2002 |
| 6437100 | DNA encoding a human histamine receptor of the H3 subtype DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce activ... | 08/20/2002 |
| 6423550 | Home oral fluid sample collection device and package for mailing of such device This reagent strip is comprised of a testing portion which contains an absorbent cotton pad. This absorbent cotton pad may be placed in the mouth on the tongue to collect an oral fluid sample. A plastic frame surrounds the pad to help hold the fluid there... | 07/23/2002 |
| 6413743 | DNA encoding a human histamine receptor of the H3 subtype DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce activ... | 07/02/2002 |
| 6372779 | Anti-inflammatory compounds This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure: ##STR1##... | 04/16/2002 |
| 6251956 | Combination progestin oral contraceptive regimen An oral contraception regimen which comprises sequentially administering two or more progestational agents exhibiting different effects on the human endometrium in combination with an estrogen. The invention is also directed to an extended use oral contra... | 06/26/2001 |
| 6235710 | Spray dried erythropoietin The present invention provides a method for preparing stable, spray dried rhEPO and the rhEPO powder produced thereby.... | 05/22/2001 |
| 6221608 | Methods for identifying erythropoietin receptor binding protein The extracellular domain of the human erythropoietin receptor (EPO binding protein, EBP) has been expressed and overproduced in E. coli. Control of oxygen levels and pH during high density fermentation allows the production of only the protein variant wit... | 04/24/2001 |
| 6171868 | Method of sampling bodily fluids The invention provides for a method of making more than one punchout from a single dried blood spot. The method comprising the steps of making a first punch and sequentially making at least a second punch in the dried blood spot. The second punch comprise... | 01/09/2001 |
| 6136559 | DNA encoding as human histamine receptor of the H3 subtype DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce activ... | 10/24/2000 |
| 6120795 | Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation A method for preparing liposomal suspensions which comprises preparing a solution of a poorly soluble protein or other poorly soluble compound and an encapsulating amount of a suitable lipid in an alcoholic solvent, injecting the resulting solution into a... | 09/19/2000 |
| 6071537 | Anticonvulsant derivatives useful in treating obesity A method for treating obesity comprising administering a therapeutically effective amount of a compound of the formula: ##STR1## is disclosed.... | 06/06/2000 |
| 6069254 | Carboxamide derivatives of piperidine for the treatment of thrombosis disorders Carboxamide derivatives of pyrrolidine, piperidine, and hexahydroazepine of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.... | 05/30/2000 |
| 6039208 | Variable day start tablet dispenser This invention relates to a substantially circular tablet dispenser component system which may be adapted for a variable day start of a prescribed periodic tablet regimen. Also provided are a tablet dispenser kit, a tablet package adapted for filling the ... | 03/21/2000 |
| 6028202 | 1,5-diarylpyrazoles Compounds of Formula I ##STR1## wherein, R1 through R7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment o... | 02/22/2000 |
| 6024938 | Lyophilized imaging agent formulation comprising a chemotactic peptide A lyophilized imaging agent formulation and methods for making same are disclosed, such formulations comprise a targeting molecule such as antibody or chemotactic peptide, a linker such as diethylenetriaminepentaacetic acid (DTPA) or succinimidyl 6-hydraz... | 02/15/2000 |
| 6013764 | Liquid phase peptide synthesis of KL-4 pulmonary surfactant The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process... | 01/11/2000 |
| 6002066 | H2-M modified transgenic mice A transgenic mouse with alterations in the H2-Ma gene is prepared by introduction of an altered H2-Ma gene into a host mouse. The resulting transgenic mice do not produce functional H2-M molecules.... | 12/14/1999 |
| 6001800 | Spray dried erythropoietin A method of preparing spray dried recombinant erythropoietin (rhEPO) is disclosed. The method comprises providing an aqueous solution of rhEPO and atomizing the solution into a spray drying the spray and separating the dried rhEPO from the drying air. Als... | 12/14/1999 |
| 5994563 | Arylmethylphosphonic acid derivatives useful in treating bone wasting diseases Benzyl-phosphonate compounds represented by the formula I: ##STR1## are disclosed as useful in treating bone wasting diseases and as an immunosuppresant.... | 11/30/1999 |
| 5955645 | Thrombin receptor deficient transgenic mice A transgenic animal with alterations in an thrombin receptor gene is prepared by introduction of an altered thrombin receptor gene into a host animal. The resulting transgenic animals do not produce functional thrombin receptor molecules.... | 09/21/1999 |
| 5952303 | Lyophilized pulmonary surfactant peptide compositions An improved solid pharmaceutical composition comprising a lyophilized liposomal KL4 pulmonary surfactant composition comprising: (a) about 1 to about 10 percent weight KL4 polypeptide; and (b) 50 to about 100 weight percent phospholipid comprised of about 3 parts ... | 09/14/1999 |
| 5942532 | 2-substituted phenyl-benzimidazole antibacterial agents The invention relates to benzimidazole antibacterial compounds of the Formula I: ##STR1## as described herein, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhib... | 08/24/1999 |
| 5922731 | 5-(heteroaryl)alkyl!-3-oxo-pyrido1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders A compound of the general formula 1; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.... | 07/13/1999 |
| 5908754 | Method for in vitro determination of in vivo erythropoeitin bioactivity The present invention is directed to an in vitro method of determining the in vivo EPO activity of a sample containing EPO. More particularly, the present method comprises treating a sample containing EPO under conditions which remove desialylated EPO, an... | 06/01/1999 |
| 5888971 | Macrocyclic peptides useful in the treatment of thrombin related disorders Compounds of Formula I ##STR1## and Formula III ##STR2## which are useful in the treatment of thrombin and trypsin related disorders.... | 03/30/1999 |
| 5885573 | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies The binding specificity of the murine OKT3 has been transferred into a human antibody framework in order to reduce its immunogenicity. This "humanized" anti-CD3 mAb (gOKT3-5) was previously shown to retain, in vitro, all the properties of native OKT3, inc... | 03/23/1999 |
| 5869674 | Arylpyrazoles as leukotriene inhibitors Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.... | 02/09/1999 |
| 5862729 | Mechanical punch apparatus and method of using same A punch assembly for punching samples of dried blood spots (DBSs) from paper card samples includes: a base member, a cartridge and at least one cutting pin. The base member includes a bottom platform having an upper surface defining a track therein, an up... | 01/26/1999 |
| 5854242 | Benzoxazine antimicrobial agents The invention relates to benzoxazine and pyrido-oxazine antibacterial compounds of the general formula: ##STR1## wherein the moiety Q is a fused phenyl or fused pyridyl moiety as herein described, pharmaceutical compositions containing the compounds,... | 12/29/1998 |
| 5843958 | Arylpyrazoles as leukotriene inhibitors Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.... | 12/01/1998 |
| 5833072 | Dosage regimen container Generally, this invention relates to dosage containers. More specifically this invention relates to dosage containers which help identify a daily regimen of dosages, or a particular time period of dosages in a day. Most specifically, this invention relate... | 11/10/1998 |
| 5834521 | Substituted dibenz (A F)azulenes and methods of preparation Tetracyclic compounds having the following structure are described: ##STR1## wherein R1 -R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased ut... | 11/10/1998 |
| 5827860 | Peptidyl heterocycles useful in the treatment of thrombin related disorders Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.... | 10/27/1998 |
| 5827866 | Peptidyl heterocycles useful in the treatment of thrombin related disorders Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.... | 10/27/1998 |
| 5817668 | S-heteroatom containing alkyl substituted-3-oxo-pyrido1,2-A!benzimidozole-4-carboxamide derivatives useful in treating central nervous system disorders A compound of the general formula 1; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.... | 10/06/1998 |
| 5799821 | Variable day start tablet dispenser This invention relates to a substantially circular tablet dispenser component system which may be adapted for a variable day start of a prescribed periodic tablet regimen. Also provided are a tablet dispenser kit, a tablet packge adapted for filling the t... | 09/01/1998 |
| 5792444 | Labeled chemotactic peptides to image focal sites of infection or inflammation The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detec... | 08/11/1998 |
| 5783597 | 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use 2,5-Disubstituted thiophene derivatives, and more particularly, to 2-aryloxy-5-alkansulfonamido-thiophenes of the general formula: ##STR1## Wherein, R2 is CF3, C1 -C10 alkyl, or phenyl; X is O, S, or CH2 | 07/21/1998 |
| 5775536 | Variable day start tablet dispenser This invention relates to a substantially circular tablet dispenser component system which may be adapted for a variable day start of a prescribed periodic tablet regimen. Also provided are a tablet dispenser kit, a tablet packge adapted for filling the t... | 07/07/1998 |
