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| Number | Title | Issue Date |
| 8178673 | Phosphonic acid compounds as inhibitors of serine proteases The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. ... | 05/15/2012 |
| 8106236 | Triaryl compounds and derivates thereof The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically accept... | 01/31/2012 |
| 8058390 | HDM2-inhibitor complexes and uses thereof The present invention includes crystallized HDM2 peptides as well as descriptions of the X-ray diffraction patterns of the crystals. The diffraction patterns allow the three dimensional structure of HDM2 to be determined at atomic resolution so that ligand binding s... | 11/15/2011 |
| 7867990 | Steroid hormone products and methods for preparing them The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having improved dissolution and release rate properties. The invention further relates to met... | 01/11/2011 |
| 7842501 | Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 11/30/2010 |
| 7820792 | CDNA encoding the human α2 δ4 calcium channel subunit The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional α2δ-4 protein. The calcium channel α2δ-4 p... | 10/26/2010 |
| 7786311 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological ... | 08/31/2010 |
| 7754730 | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions com... | 07/13/2010 |
| 7723295 | Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 05/25/2010 |
| 7718673 | Isonipecotamides for the treatment of integrin-mediated disorders The invention is directed to novel isonipecotamide derivatives of Formula (I): which are useful in treating integrin-mediated disorders. ... | 05/18/2010 |
| 7691844 | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, wh... | 04/06/2010 |
| 7576056 | Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 08/18/2009 |
| 7575888 | Method of determining chymase activity with secretory leukocyte protease inhibitor It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a ... | 08/18/2009 |
| 7557244 | Substituted biphenyl carboxylic acids and derivatives thereof The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, and R10 given below, and/or a salt or ester thereof. Furthermore the inventi... | 07/07/2009 |
| 7524643 | CDNA encoding the human alpha2 delta4 calcium channel subunit The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional α2δ-4 protein. The calcium channel α2δ-4 p... | 04/28/2009 |
| 7504414 | Substituted benzimidazoles and imidazo-[4,5]-pyridines 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 03/17/2009 |
| 7482364 | Phenylalkynes Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 01/27/2009 |
| 7468373 | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions com... | 12/23/2008 |
| 7459461 | Phosphonic acid compounds as inhibitors of serine proteases The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. ... | 12/02/2008 |
| 7446104 | Phenylalkynes Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 11/04/2008 |
| 7427683 | c-fms kinase inhibitors The invention is directed to compounds of Formulae I: wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceu... | 09/23/2008 |
| 7417030 | Indazole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, athero... | 08/26/2008 |
| 7408036 | Human voltage gated sodium channel β1A subunit and methods of use DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant prot... | 08/05/2008 |
| 7402586 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12—R15, R | 07/22/2008 |
| 7399767 | Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors The present invention is directed to novel heterocyclic benzo[c]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the... | 07/15/2008 |
| 7375123 | 1,2,4-thiadiazole derivatives as melanocortin receptor modulators The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disor... | 05/20/2008 |
| 7358261 | Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alky... | 04/15/2008 |
| 7354742 | Method for generating amplified RNA The present invention provides a new method for producing amplified RNA from a selected set of cells. This method combines and utilizes known methods in a novel way to produce the gene expression profiles. The methods of the present invention utilize thermostable DN... | 04/08/2008 |
| 7345052 | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions com... | 03/18/2008 |
| 7329657 | Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or am... | 02/12/2008 |
| 7317005 | Tricyclic benzodiazepines as vasopressin receptor antagonists The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the prese... | 01/08/2008 |
| 7317031 | Substituted triazole diamine derivatives as kinase inhibitors The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder. ... | 01/08/2008 |
| 7312306 | Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the... | 12/25/2007 |
| 7312045 | Aggrecanase-1 and -2 peptide substrates and methods The present invention describes synthetic peptide substrates of the metalloproteases, aggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these prot... | 12/25/2007 |
| 7304060 | Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or am... | 12/04/2007 |
| 7288540 | Phenylalkynes Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4 | 10/30/2007 |
| 7282480 | Aqueous sustained-release formulations of proteins The present invention is directed to sustained-release pharmaceutical formulations of therapeutic proteins containing carboxymethyl ether cellulose polymer and methods of manufacture and use thereof. ... | 10/16/2007 |
| 7271261 | Substituted benzimidazoles and imidazo-[4,5]-pyridines 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 09/18/2007 |
| 7265135 | 2-oxy, 2-amino, and 2-thio-imidazole compounds The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compo... | 09/04/2007 |
| 7259146 | Neuroprotective peptides Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and... | 08/21/2007 |
