Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8183213 | Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators Combination therapy comprising RXR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed. ... | 05/22/2012 |
| 7452708 | Human PRSS11-like S2 serine protease and uses thereof A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L... | 11/18/2008 |
| 7388011 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S. ... | 06/17/2008 |
| 7384979 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which ... | 06/10/2008 |
| 7365062 | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, wh... | 04/29/2008 |
| 7265102 | Substituted pyrazoles Substituted pyrazoles of general formula methods of manufacturing them, compositions containing them, and methods of using them to, for example, treat autoimmune diseases mediated by cathepsin S, and inhibit cath... | 09/04/2007 |
| 7241778 | Non-imidazole aryloxypiperidines Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions. ... | 07/10/2007 |
| 7205384 | Process for preparing peptidyl heterocyclic ketone derivatives The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to... | 04/17/2007 |
| 7049401 | Human histamine receptor of the H3 subtype DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombina... | 05/23/2006 |
| 6943149 | Benzimidazolone peptidomimetics as thrombin receptor antagonists The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke,... | 09/13/2005 |
| 6924302 | Substituted triazole diamine derivatives as kinase inhibitors The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder. ... | 08/02/2005 |
| 6855560 | Method of identifying compounds that modulate human histamine H3 receptor DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombina... | 02/15/2005 |
| 6750369 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which... | 06/15/2004 |
| 6696056 | Pharmaceutical compositions of erythropoietin The present invention provides aqueous pharmaceutical formulations of erythropoietin that are free of human serum blood products, stabilized with a quantity of an amino acid and a sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) derivative. The pres... | 02/24/2004 |
| 6518285 | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials Piperidinyloxy, pyrrolidinyloxyl and azetidinyloxy compounds of the formula: ##STR1## wherein R1 is a piperidinyl, pyrrolidinyl or azetidinyl moiety as described herein and in which the substituents have the meaning indicated in the descri... | 02/11/2003 |
| 6511980 | Substituted diamine derivatives useful as motilin antagonists The present invention relates to novel substituted diamine derivatives for the formula ##STR1## wherein R1, R2, R3, R4, X1, X2, X3, X4, A, Y and n are as described in ... | 01/28/2003 |
| 6512120 | Methods for the synthesis of densely functionalized pyrrolidine intermediates This invention is directed to methods of synthesizing densely functionalized pyrrolidine compounds through the use of intramolecular Diels Alder reactions.... | 01/28/2003 |
| 6372955 | Methods for Producing B cells and antibodies from H2-O modified transgenic mice A transgenic animal with alterations in an H2-O gene is prepared by introduction of an altered H2-O gene into a host animal. The resulting transgenic animals produce a substantially greater frequency of high affinity antibodies compared to H2-O wild type ... | 04/16/2002 |
| 6147096 | Substituted pyrrolobenzimidazoles for treating inflammatory diseases This invention provides compounds, and pharmaceutically acceptable salts thereof, having the structure shown below, as well as related pharmaceutical compositions, and methods of treatment and synthesis. ##STR1##... | 11/14/2000 |
| 6033671 | Identification of human cytomegalovirus genes involved in down-regulation of MHC class I heavy chain expression The human cytomegalovirus (HCMV) genomic US region encodes a family of homologous genes essential for the inhibition of major histocompatiblity complex (MHC) class I mediated antigen presentation observed during viral infection. Here we show that US3 and ... | 03/07/2000 |
