Assignee: Ortho-Clinical Diagnostics, Inc.

Location: Rochester, NY
No. of patents: 51

Number	Title	Issue Date
8092361	Split spin centrifugation of test elements High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of...	01/10/2012
8080204	Two dimensional sample handler A method for positioning a sample in a diagnostic analyzer includes: providing two or more sample carriers on a conveyor; providing a fixed registration element for each sample carrier at predetermined locations along the conveyor; providing a flexure device positio...	12/20/2011
8076126	Single column immunological test elements A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover str...	12/13/2011
8058073	Immunodiagnostic test cards having indicating indicia An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid ...	11/15/2011
8048376	Particle agglutination in a tip An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particle...	11/01/2011
8043562	Analyzer having removable holders or a centrifuge An analyzer, preferably a desktop analyzer, includes: a component transport system; a liquid dispense or aspirating station; a member removably located on the transport system. The removable holder includes: a probe tip dispenser; a fluid supply section for holding ...	10/25/2011
8026101	Failure detection in automated clinical analyzers The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will ...	09/27/2011
8012766	Prediction of aspirated volume of a liquid Aspirating a liquid, includes: providing an aspirating probe comprising probe tip and piston pump, wherein the probe tip and piston pump are in fluid communication; measuring an initial gas pressure in the probe prior to liquid entering the liquid being aspirated; m...	09/06/2011
7846395	Container closure and device to install and remove closure A closure for a container includes: (a) an inner cylindrical wall having first and second ends and defining a space; (b) an outer cylindrical wall opposite the inner cylindrical wall and having the first and second ends to form an outer surface of the closure; (c) a...	12/07/2010
7867768	Two dimensional sample handler A method for positioning a sample in a diagnostic analyzer includes: providing two or more sample carriers on a conveyor; providing a fixed registration element for each sample carrier at predetermined locations along the conveyor; providing a flexure device positio...	01/11/2011
7855084	Chemistry system for clinical analyzer A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one ...	12/21/2010
7850917	Particle agglutination in a tip An apparatus and a related method for performing particle agglutination reactions in a single, disposable probe tip are disclosed. The probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugat...	12/14/2010
7816090	Multiple immunochemistry assays on an element A method of analyzing a sample for one or more analytes of interest includes: providing an element having a base layer; a layer containing streptavidin; a spreading layer, wherein the streptavidin may or may not be in the spreading layer; providing immunocomponents ...	10/19/2010
7803101	Random access multi-disc centrifuge A centrifuge includes: a plurality of centrifuge discs each disc having an attachment for attaching a container containing a liquid to be centrifuged; a disc driver positioned to engage and rotate the discs; a disc engager/disengager for individually moving each of ...	09/28/2010
7799283	Heating and cooling multiple containers or multi-chamber containers A device for heating or cooling multiple single chamber containers or a multi-chamber container. The device includes: a unitary heat or cold source providing a source of heat or cold; heat exchange elements in thermal communication with the heat or cold source and e...	09/21/2010
7792647	Quantitatively measuring error causing parameters in fluid handling A method for quantitatively measuring error causing physical parameters in a fluid handling system, includes: measuring the pressure of air between a piston of a pump and a liquid being handled; detecting a pressure abnormality; determining the time at which the pre...	09/07/2010
7655233	Optimal placement of a robust solvent/detergent process post viral ultrafiltration of an immune gamma globulin The solvent-detergent (S/D) process is used to inactivate enveloped viruses in plasma products. While concentrations of 1.0% detergent and 0.3% tri-n-butyl phosphate solvent have been considered necessary for robust removal of viral activity, we show the effectivene...	02/02/2010
7634367	Estimating fluidic properties and using them to improve the precision/accuracy of metered fluids and to improve the sensitivity/specificity in detecting failure modes A method for improving the accuracy or precision of a metered fluid includes: estimating a fluidic property of the fluid being metered; and adjusting one or more control parameters based on the estimated property to improve the accuracy or precision of a metered flu...	12/15/2009
7632468	Retaining clip for reagent test slides A retaining clip for retaining reagent test slides in a stacked arrangement includes a first assembly having a first cover plate and at least two parallel, co-planar rails extending transversely from an inner surface of the first cover plate. A second assembly inclu...	12/15/2009
7615346	Rapid and efficient capture of DNA from sample without using cell lysing reagent Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, ...	11/10/2009
7597847	Analyzer having a stationary multifunction probe An analyzer, preferably a desktop analyzer, includes: a stationary probe capable of dispensing or aspirating a liquid; one or more of a movable test element or movable liquid source; and a conveyor for moving the movable test element or liquid source with respect to...	10/06/2009
7569189	Opening and closing a container An apparatus for opening and closing a container having a slidable shutter closure moving past the apparatus includes: a rotatable shaft having an axis perpendicular to the direction of travel of the slidable shutter, the shaft being biased against rotation in eithe...	08/04/2009
7517694	Metering tip with internal features to control fluid meniscus and oscillation A metering tip for use in a clinical analytical apparatus includes a tapered body having at least one interior stepped areas. Each of the stepped areas include a sharp diametrical edge for latching a fluid meniscus being dispensed from the tip and for reducing fluid...	04/14/2009
7402282	Auxiliary sample supply for a clinical analyzer A sample handler includes a plurality of sealable metering tips, each of the tips, when sealed, containing a fluid volume of a test fluid and in which each of the sealed metering tips acts as an auxiliary sample supply container for use with at least one chemistry s...	07/22/2008
7399603	Antibodies for discrimination of prions In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans. ...	07/15/2008
7378057	Evaporation control for a fluid supply Evaporation control for a fluid supply, such as used in a clinical analyzer, can be provided by utilizing a straw-like insert which is disposed into a fluid-containing bottle. The straw provides an increased diffusion length or “stagnant” zone. The bottle can al...	05/27/2008
7353953	Packaging of multiple fluid receptacles Packaged fluid receptacles include: a plurality of fluid receptacles arranged one next to the other to form a composite structure having a top surface, bottom surface and end walls at a first end and a second end and having a longitudinal axis which extends through ...	04/08/2008
7332269	HCV core protein sequences The present invention describes peptides and recombinant proteins containing Hepatitis C virus core protein sequence in which one or more of the amino acids have been modified or deleted to remove the ability of these proteins to bind to specific anti-HCV murine mon...	02/19/2008
7312084	Tandem incubator for clinical analyzer An incubator includes an incubator ring assembly having at least two concentric rings supported for rotation about a common axle defining an axis of rotation. Each concentric ring includes a plurality of circumferentially defined load positions, each load position b...	12/25/2007
7307718	Determining an analyte by multiple measurements through a cuvette A method for measuring the presence or concentration of an analyte in a sample by spectrophotometry: providing an open top cuvette having a sample with an analyte to be measured; providing a light source and a detector for detecting emitted light; taking at least tw...	12/11/2007
7282372	Fluid measurements in a reaction vessel used in conjunction with a clinical analyzer A method for measuring the amount of fluid contained in a reaction vessel in a clinical analyzer includes the steps of adding a first aliquot of fluid to the reaction vessel and measuring the quantity of fluid contained therein. A second aliquot of fluid is then add...	10/16/2007
7262006	Rapid and efficient capture of DNA from sample without using cell lysing reagent Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, ...	08/28/2007
7256045	Analyzer with sample quality measurement, and method A system for detecting and analyzing patient sample quality and/or analytes, while the sample is in the metering tip used to aspirate the sample liquid from an original patient sample container, and also to dispense the liquid onto a slide test element. Spectrophoto...	08/14/2007
7250303	Chemistry system for a clinical analyzer A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one ...	07/31/2007
7159979	Rotationally stabilized contact lenses The invention provides a lens in which the lens periphery is controlled as to each of thickness differential and both the rate of change from thinner to thicker regions and the shape of the transition from thinner to thicker regions within each of the dual thin zone...	01/09/2007
7067247	Hepatitis B virus surface protein We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be persistently positive for both for HBsAg and anti-HBs Antibody (Ab) with ...	06/27/2006
7049060	HCV anti-core monoclonal antibodies Monoclonal antibodies that specifically bind to HCV core antigen. Also provided are hybridoma cell lines which secrete these antibodies, methods for making and using these antibodies, including kits that include these antibodies. ...	05/23/2006
6955889	Simultaneous determination of forward and reverse ABO blood group Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be performed separately, but A and B agglutinates can be detected and discri...	10/18/2005
6937955	Method for automatic alignment of metering system for a clinical analyzer A method for calibrating a clinical analyzer having a dispenser, and for automatically aligning the dispenser of the clinical analyzer includes loading a calibration element at a portion of the clinical analyzer; moving a dispenser of the clinical analyzer in a pre-...	08/30/2005
6913933	Fluid dispensing algorithm for a variable speed pump driven metering system A method for improving the fluid dispense rate in a metering system utilizing speed includes the steps of modifying the fluid flow rate profile during a portion thereof so as substantially increase or decrease the speed of the motor during certain portions of a mete...	07/05/2005

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Assignee: Ortho-Clinical Diagnostics, Inc.