Assignee: Organogenesis Inc.

Location: Canton, MA
No. of patents: 38

Number	Title	Issue Date
7348176	Chamber with adjustable volume for cell culture and organ assist The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates san...	03/25/2008
7214242	Bioengineered tubular graft prostheses The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bior...	05/08/2007
7157278	Cultured cells from pancreatic islets A cell composition of endocrine progenitor cells derived from mammalian pancreatic islet cells that can be trans-planted into a diabetic patient such that the cells of the cell composition differentiates into functioning insulin-producing beta cells. ...	01/02/2007
7121999	Method of preparing layered graft prostheses The invention is directed to bioengineered graft prostheses made from two or more superimposed, chemically bonded layers of processed tissue material prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the inventi...	10/17/2006
7060103	Tissue repair fabric A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis...	06/13/2006
7041131	Bioengineered vascular graft support prostheses The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength,...	05/09/2006
7025916	Process of making bioengineered collagen fibrils The invention is directed to a class of fiber or strand suspension compositions that may be processed further into viscoelastic pastes or porous solids. The preferred compositions of the invention comprise biologically derived or biologically compatible materials, s...	04/11/2006
6986735	Method of making a bioremodelable vascular graft prosthesis The invention is directed to methods of making bioremodelable graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strengt...	01/17/2006
6978815	System and method for forming bioengineered tubular graft prostheses An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning a...	12/27/2005
6893653	Chemical cleaning of biological material The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. T...	05/17/2005
6890351	Method for treating diseased or damaged organs A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides ...	05/10/2005
6855542	Chamber with adjustable volume for cell culture and organ assist The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates san...	02/15/2005
6759245	Cell culture systems and methods for organ assist devices The invention features modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are gro...	07/06/2004
6730510	Culture dish and bioreactor system A bioreactor has a base for defining a well, a dish with a membrane suspended in the base, and a lid with gas permeable membranes and self-sealing ports. ...	05/04/2004
6699716	In vivo induction for enhanced function of isolated hepatocytes The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The in...	03/02/2004
6599690	Chemical cleaning of biological material The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native...	07/29/2003
6592794	Process of making bioengineered collagen fibrils The invention is directed to a class of fiber or strand suspension compositions that may be processed further into viscoelastic pastes or porous solids. The preferred compositions of the invention comprise biologically derived or biologically compatible m...	07/15/2003
6572650	Bioengineered vascular graft support prostheses The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility...	06/03/2003
6394812	Vivo induction for enhanced function of isolated hepatocytes The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The in...	05/28/2002
6347525	Ice seeding apparatus for cryopreservation systems This invention is directed to a method of ice seeding a biological samples, such as cells, harvested tissues, and cellular biological constructs such as culture tissue equivalents. The method initiates the formation of ice that is controllable to allow fo...	02/19/2002
6334872	Method for treating diseased or damaged organs This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and e...	01/01/2002
6228607	Bioreactor The invention relates to a bioreactor for a cell treatment of a medium. Said bioreactor comprises an element defining a chamber in which cells for treating the medium are located, a liquid permeable membrane separating the said chamber from a first channe...	05/08/2001
6167710	Ice seeding apparatus for cryopreservation systems An apparatus for ice seeding during cryopreservation of biological samples such as cells, harvested tissues, and cellular biological constructs such as culture tissues equivalents wherein ice seeding is performed by discharging a liquefied or chilled gas ...	01/02/2001
5997896	Reconstituted collagen fiber segment compositions and methods of preparation thereof The invention provides injectable collagen compositions that are reconstituted collagen fiber segments made from acid extracted collagen with telopeptides in a biocompatible carrier, with the collagen concentration in the composition ranging up to 200 mg/...	12/07/1999
5993844	Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native...	11/30/1999
5964096	Method and package design for cryopreservation and storage of cultured tissue equivalents This invention is directed to an efficient cryopreservation package desgin of harvested mammalian tissues and living cultured tissue equivalents made by in vitro technology. The invention involves immersing a mammalian tissue or cultured tissue equivalent...	10/12/1999
5891617	Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing This invention is directed to cryopreservation of harvested mammalian tissues and living cultured tissue equivalents made by in vitro technology. The invention involves immersing a mammalian tissue or cultured tissue equivalent in a cryoprotectant solutio...	04/06/1999
5766937	Culture vessel and assembly An assembly and components therefor are disclosed for use in the field of cell and tissue culture. The assembly includes a base having one or more wells, and a cell culture insert which is mountable to the base such that the bottom wall of the insert is s...	06/16/1998
5733337	Tissue repair fabric This invention is directed to prosthesis, which, when implanted into a mammalian patient, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the...	03/31/1998
5718012	Method of strength enhancement of collagen constructs A method for improving the tensile strength of wet collagen threads or collagen thread constructs for implantation to replace or repair tissue or organs wherein the strength of the threads is improved by plasticizing the threads with a plasticizing agent,...	02/17/1998
5712163	Chemically defined cell culture media and system and methods for use, particularly for culturing epithelial cells The present invention provides systems, methods and chemically defined media for the cultivation of cells, particularly epithelial cells. Cells may be cultured with a varied calcium concentration. Furthermore, a calcium concentation in excess of 1.00 mM m...	01/27/1998
5689961	Ice seeding apparatus for cryopreservation systems An apparatus for ice seeding during cryopreservation of biological samples such as cells, harvested tissues, and cellular biological constructs such as culture tissue equivalents wherein ice seeding is performed by discharging a liquefied or chilled gas f...	11/25/1997
5536656	Preparation of tissue equivalents by contraction of a collagen gel layered on a collagen gel Tissue equivalents are produced by applying a solution of collagen without cells to a permeable membrane, gelling to produce a collagen gel on the membrane, applying a mixture of collagen and a contractile agent to the collagen gel, gelling the mixture an...	07/16/1996
5518878	Cryopreservation of cultured skin or cornea equivalents with agitation This invention is directed to cryopreservation of cultured tissue equivalents made by in vitro technology. The invention involves immersing a cultured tissue equivalent in a cooled cryoprotectant solution, agitating the cryoprotectant solution and the imm...	05/21/1996
5460962	Peracetic acid sterilization of collagen or collagenous tissue This invention is directed to the sterilization of collagen and collagenous tissue which is to be used for implantation, repair, or use in a mammalian host in the emerging field of tissue engineering. The sterilants are low concentration peracetic acid so...	10/24/1995
5378469	Collagen threads The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads....	01/03/1995
5374515	In vitro cornea equivalent model This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an i...	12/20/1994
5256418	Collagen constructs The present invention provides collagen constructs and methods of making and using such constructs. The present invention also provides tissue equivalents having improved characteristics and methods of making and using such tissue equivalents. This invent...	10/26/1993

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Assignee: Organogenesis Inc.