Assignee: Onyx Pharmaceuticals, Inc.

Location: Richmond, CA
No. of patents: 44

Number	Title	Issue Date
7141404	cytosine deaminase A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme. ...	11/28/2006
6890747	Phosphoinositide 3-kinases The present invention relates PI3K crystals, polypeptide muteins, polypeptide fragments, antibodies thereto, nucleic acids coding for these polypeptides, methods of modifying PI3Kγ activity, and methods of modulating PI3Kγ activity. These include polypeptides and ...	05/10/2005
6764674	Adenovirus E1B shuttle vectors Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, and optionally the substitution therefore of a heterologous gene that substantially exhibits the temp...	07/20/2004
6762284	Nucleotide sequences that encode phosphatidylinositol-3′ kinase associated proteins and uses thereof Identification, characterization and expression of nucleotides that encode phosphatidylinositol-3′kinase associated protein(s) that bind to the intermediate SH2 domain on the regulatory subunit of PI3K, p85, by the associated protein(s) C-terminal amino acids, and...	07/13/2004
6723316	Herpes simplex virus-1 Glycoprotein C mutants for treating unwanted hyperproliferative cell growth The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex virus, which is cytopathic to susceptible target cells, such as neoplastic cells. Preferably, the virus does not produce a funct...	04/20/2004
6682920	Compositions and methods for identifying PKB kinase inhibitors Compositions and methods are described that are useful to assay for compouds that affect PKB kinase activity which have medical applications for the diagnosis and treatment of disease....	01/27/2004
6660259	Herpes simplex virus for treating unwanted hyperproliferative cell growth The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex-type 1 virus, which is cytopathic to susceptible hyperproliferative cells, such as neoplastic cells. Preferably, the ...	12/09/2003
6635244	Adenovirus E1B-55K single amino acid mutants and methods of use Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for trea...	10/21/2003
6569655	Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustr...	05/27/2003
6558918	Nucleic acid that encode a cell growth regulatory protein Compositions of matter consisting of a family of related nucleic acid sequences that encode proteins, termed Cell Growth Regulatory Proteins, that phosphorylate cell cycle targets, and methods of using the nucleotide sequences and the proteins encoded the...	05/06/2003
6511825	Cell signaling polypeptides and nucleic acids The present invention relates to an isolated SRK polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, in...	01/28/2003
6500653	Nucleic acids and polypeptides which resemble RHO and which interact with cell signaling pathways and proteins The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction...	12/31/2002
6428960	Selection method for producing recombinant baculovirus The present invention provides a novel method for producing recombinant baculoviruses expressing genes of interest by inserting a selectable marker gene, specifically the puromycin resistance (pac) gene, adjacent to the gene of interest into the baculovir...	08/06/2002
6391630	Plasmids that encode green fluorescent protein Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that...	05/21/2002
6379665	Phospholipase D polypeptide and DNA sequences Provided are novel phospholipase D DNA and amino acid sequences. The sequences are useful in methods and compositions for identifying phospholipase D mediator molecules which are in turn useful in therapeutic pharmaceutical compositions for treating rheum...	04/30/2002
6340575	Methods and compositions for treating abnormal cell growth related to unwanted guanine nucleotide exchange factor activity Methods and compositions are described that affect the GTPase activity of members of the Ras superfamily, preferably Rac, such compositions include guanine nucleotide exchange factors that modulate the GTPase activity, preferably in the presence of GEF en...	01/22/2002
6296845	Selective killing and diagnosis of p53+ neoplastic cells Methods and compositions for treating and diagnosing neoplastic disease using viruses are provided. Preferably, mutant adenovirus lacking viral proteins which bind and/or inactivate p53 are administered to a patient having a neoplasm which comprises cells...	10/02/2001
6238881	Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustr...	05/29/2001
6225060	Baculovirus expression system and method for high throughput expression of genetic material The present invention provides novel recombinant baculovirus expression systems for expressing foreign genetic material in a host cell. Such expression systems are readily adapted to an automated method for expression foreign genetic material in a high th...	05/01/2001
6187799	Inhibition of raf kinase activity using aryl ureas Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se....	02/13/2001
6133419	Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof Identification, characterization and expression of nucleotides that encode phosphatidylinositol-3' kinase associated protein(s) that bind to the intermediate SH2 domain on the regulatory subunit of PI3K, p85, by the associated protein(s) C-terminal amino ...	10/17/2000
6133243	Liposomal-viral DNA complexes for treating disease Methods and compositions for treating cancer consisting of viral DNA in association with liposomal material, the viral DNA substantially incapable of encoding a functional viral oncoprotein capable of binding to a functional tumor suppressor gene product ...	10/17/2000
6080578	Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 a...	06/27/2000
6048706	Human PAK65 A novel human serine protein kinase, human p21-protein activated serine kinase p65 protein, referred to as hPAK65, and methods for its preparation and use are provided. Nucleic acids encoding hPAK65 and methods for their use in preparing hPAK65 as well as...	04/11/2000
6017763	G-beta-gamma regulated phosphatidylinositol-3' kinase The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3' kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (...	01/25/2000
6013464	Human PAK65 A novel human serine protein kinase, human p21-protein activated serine kinase p65 protein, referred to as hPAK65, and methods for its preparation and use are provided. Nucleic acids encoding hPAK65 and methods for their use in preparing hPAK65 as well as...	01/11/2000
5972706	Cytopathic viruses for therapy and prophylaxis of neoplasia Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 a...	10/26/1999
5948643	Modulators of BRCA1 activity Compositions of matter consisting of a family of related nucleotide sequences that encode proteins, termed BRCA1 Modulator Proteins, that bind to the tumor suppressor gene product BRCA1, and methods of using the nucleotide sequences and the proteins encod...	09/07/1999
5876711	Methods and compositions for determining the tumor suppressor status of cells Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that...	03/02/1999
5874273	G-beta-gamma regulated phosphatidylinositol-3' kinase The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3' kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (...	02/23/1999
5869271	G-beta-gamma regulated phosphatidylinositol-3' kinase The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3' kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (...	02/09/1999
5859201	G-beta-gamma regulated phosphatidylinositol-3' kinase The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3' kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (...	01/12/1999
5856132	G-beta-gamma regulated phosphatidylinositol-3' kinase The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3' kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (...	01/05/1999
5856181	Cytopathic viruses for therapy and prophylaxis of neoplasia Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 a...	01/05/1999
5856133	G-beta-gamma regulated phosphatidylinositol-3'kinase The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3'kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (3...	01/05/1999
5801029	Cytopathic viruses for therapy and prophylaxis of neoplasia Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 a...	09/01/1998
5756669	P53-binding polypeptides and polynucleotides encoding same The invention provides mammalian polypeptides which bind wild-type and/or mutant mamalian p53 proteins, polynucleotides encoding such polypeptides, screening assays for drug development employing such polypeptides and polynucleotides, immunological and ot...	05/26/1998
5705342	Interaction of BCL-2 and R-RAS The invention provides compositions and methods for screening for agents which are modulators of bcl-2 function and can modulate bcl-2-mediated apoptosis and/or modulate neoplastic and immune conditions dependent upon bcl-2 function. The invention also pr...	01/06/1998
5698428	Human PAK65 A novel human serine protein kinase, human p21-protein activated serine kinase p65 protein, referred to as hPAK65, and methods for its preparation and use are provided. Nucleic acids encoding hPAK65 and methods for their use in preparing hPAK65 as well as...	12/16/1997
5698445	Human PAK65 A novel human serine protein kinase, human p21-protein activated serine kinase p65 protein, referred to as hPAK65, and methods for its preparation and use are provided. Nucleic acids encoding hPAK65 and methods for their use in preparing hPAK65 as well as...	12/16/1997

«First «Previous1 2 Next»Last»

PatentStorm

Bizarre Patents

PatentStorm News

Assignee: Onyx Pharmaceuticals, Inc.