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| Number | Title | Issue Date |
| 6528324 | Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers wherein each carrier has a uniform array of distinct support... | 03/04/2003 |
| 6508938 | Apparatus and method for multiple channel high throughput purification A multiple channel high throughput purification system for purifying a plurality of samples, preferably four or more samples from a chemical library. The high throughput purification uses chromatography, and more preferably, super critical fluid chromatog... | 01/21/2003 |
| 6458273 | Sample separation apparatus and method for multiple channel high throughput purification A high throughput liquid chromotagraphy column assembly for separating a large sample with a selected mass weight and fluid volume. The assembly includes a loading column with a loading chamber with a first inner diameter and a first length. The loading c... | 10/01/2002 |
| 6416718 | Sample wash station assembly A wash station assembly and method for washing selected samples in a sample containing assembly. The wash station assembly includes a wash station having a frame and a fluid dispensing assembly connected to the frame. The fluid dispensing assembly has a s... | 07/09/2002 |
| 6410586 | Modulators of protein tyrosine phosphatases (PTPases) The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B. CD45, SHP-1... | 06/25/2002 |
| 6410556 | Modulators of protein tyrosine phosphateses (PTPases) Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, ... | 06/25/2002 |
| 6388076 | Protein tyrosine phosphatase-inhibiting compounds Y--X--C(R').dbd.C(R")COOR'" (A1) The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to t... | 05/14/2002 |
| 6358413 | Microsampling apparatus and method for multiple channel high throughout purification A microsampling device useable in a multiple channel high throughput purification system for purifying a plurality of samples, preferably four or more samples from a chemical library. One aspect of the invention provides a microsampling device for use in ... | 03/19/2002 |
| 6358414 | Pressure regulation apparatus and method for multiple channel high throughput purification A pressure regulator assembly usable in, as an example, a multiple channel high throughput purification system. The pressure regulator assembly includes an inlet line and an outlet line connectable to a fluid channel. A regulator body has a regulator inle... | 03/19/2002 |
| 6355164 | Sample collection apparatus and method for multiple channel high throughput purification A fraction collection assembly having a frame and a dispensing head movably connected to the frame for movement about three axes. The dispensing head has a dispensing tube that receives and dispenses the sample portion. The dispensing head is movable betw... | 03/12/2002 |
| 6309541 | Apparatus and method for multiple channel high throughput purification A multiple channel high throughput purification system for purifying a plurality of samples, preferably four or more samples from a chemical library. The high throughput purification uses chromatography, and more preferably, super critical fluid chromatog... | 10/30/2001 |
| 6262044 | Modulators of protein tyrosine phosphatases (PTPASES) The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1... | 07/17/2001 |
| 6171555 | Reaction block docking station A docking station includes remotely actuated locking mechanisms for secure registration of reaction blocks, and provides for introduction of gases, liquids, and vacuum to the reaction blocks.... | 01/09/2001 |
| 6107274 | Piperazines as inhibitors of fructose-1,6-bisphosphatase (FBPase) Compounds of formula A are disclosed: ##STR1## wherein R1 is aralkyl or cycloalkyl; R2 is cycloalkylmethyl, alkyl, or aralkyl; R3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene; R | 08/22/2000 |
| 5976470 | Sample wash station assembly A wash station assembly and method for washing selected samples in a sample containing assembly. The wash station assembly includes a wash station having a frame and a fluid dispensing assembly connected to the frame. The fluid dispensing assembly has a s... | 11/02/1999 |
| 5965558 | Modulators of proteins with phosphotyrosine recognition units Y--X--C(R').dbd.C(R")COOR"' (A1) The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to th... | 10/12/1999 |
| 5866569 | Naphthalenedione nitric oxide synthase (NOS) inhibitors There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the formula I:. when R2 is H then R1 is selected from the group consisting of: 1) aryl,--NH--C0 -C | 02/02/1999 |
| 5840721 | Imidazole derivatives as MDR modulators The present invention relates to polysubsituted imidazole having formula 1 ##STR1## These compounds are useful for restoring the sensitivity of multidrug resistant cells to cancer chemotherapeutic agents.... | 11/24/1998 |
| 5770157 | Methods and apparatus for the generation of chemical libraries Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction c... | 06/23/1998 |
| 5770455 | Methods and apparatus for synthesizing labeled combinatorial chemistrylibraries The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structur... | 06/23/1998 |
| 5770620 | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors The present invention provides novel protein tyrosine phosphatase modulating compounds having an aryl acrylic acid structure, compositions comprising the compounds, and methods of making and using the same.... | 06/23/1998 |
| 5756527 | Imidazole derivatives useful as modulators of multi drug resistances The present invention relates to imidazole derivatives having formula 1 ##STR1## wherein: R1 is selected from the group consisting of: mono-,di-,and tri-substituted phenyl or thienyl, the substituents are selected from the group consisting... | 05/26/1998 |
| 5753687 | Modulators of proteins with phosphotryrosine recognition units Y--X--C(R').dbd.C(R")COOR'" (A1) The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions compr... | 05/19/1998 |
| 5723451 | Nitric oxide synthase (NOS) inhibitors There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the Formula I: ##STR1## to a patient in need of such inhibition such as hypotension, inflammation, autoimmune diseases and ... | 03/03/1998 |
| 5700826 | 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance This invention relates to compounds of Formula 1 which are pharmacologically useful for the treatment of cancer through sensitization of multi-drug resistant cancer cells to chemotherapeutic agents. ##STR1## wherein R1, R2, R | 12/23/1997 |
| 5609826 | Methods and apparatus for the generation of chemical libraries Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction c... | 03/11/1997 |
