Assignee: Oncogen

Location: Seattle, WA
No. of patents: 43

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Number	Title	Issue Date
6194200	Expression systems for preparation of polypeptides in prokaryotic cells Expression cassettes for enhanced expression and production of a polypeptide of interest in prokaryotic cells are provided. The expression cassettes provide for production of the polypeptide of interest so that such polypeptide can either be secreted from...	02/27/2001
5786456	Bp 50-specific antibodies and fragments thereof A new B-cell receptor, Bp50, a 50 kilodalton polypeptide, that functions in B-cell proliferation is described. Ligands such as lymphokines, antibody molecules or the Fv fragments of antibody molecules that bind to Bp50 and augment the proliferation of act...	07/28/1998
5766588	Tumor immunotherapy using anti-idiotypic antibodies The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T l...	06/16/1998
5645835	Therapeutic antibody based fusion proteins The present invention relates to methods of providing a targeted, amplified antitumor immune response using antibody-based fusion proteins. More specifically, the invention relates to the use of antibody-based fusion proteins comprising an immunoglobulin ...	07/08/1997
5614610	Tumor immunotherapy using anti-idiotypic antibodies The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T l...	03/25/1997
5545548	Thermally stable cytosine deaminase from saccharomyces Thermally stable cytosine deaminase (CDase), and the gene coding therefor, is disclosed as well as methods of isolating, purifying, and recombinantly producing the same. The thermally stable CDase can be isolated from Saccharomyces cerevisiae. The yeast i...	08/13/1996
5340925	Normal human growth regulatory receptor for TGF-ଲ Type III TGF-ଲ receptor is identified in and purified from normal human embryonic palatal mesenchyme (HEPM) cells and the purified product characterized structurally and functionally. HEPM cells were found to express high levels of the type III TGF-...	08/23/1994
5314995	Therapeutic interleukin-2-antibody based fusion proteins The present invention relates to antibody-based fusion proteins wherein a portion of an immunoglobulin molecule is linked to a biologically active ligand. In particular embodiments of the invention, the fusion protein comprises a portion of an antibody wh...	05/24/1994
5262177	Recombinant viruses encoding the human melanoma-associated antigen Peptides or proteins related to a melanoma associated antigen are described. These are produced in large quantities via recombinant DNA techniques and/or by chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulat...	11/16/1993
5248666	Methods for inhibiting neoplastic cell proliferation using platelet factor 4 Novel polypeptide compositions are provided which inhibit human tumor cell growth, which may or may not stimulate autophosphorylation of pp6src and induce the release of a 52 kD polypeptide from neoplastic cells. Individual polypeptides may be isolated fr...	09/28/1993
5247069	Ligands and methods for augmenting B-cell proliferation A new B-cell receptor, Bp50, a 50 kilodalton polypeptide, that functions in B-cell proliferation is described. Ligands such as lymphokines, antibody molecules or the Fv fragments of antibody molecules that bind to Bp50 and augment the proliferation of act...	09/21/1993
5244793	TGF-댡/댢: a novel chimeric transforming growth factor-beta A chimeric transforming growth factor-beta termed TGF-댡/댢, a DNA molecule encoding TGF-댡/댢, a mammaliam cell transformed with said DNA molecule, and a method for producing chimeric TGF-댡/댢 are disclosed....	09/14/1993
5242824	Monoclonal antibody to human carcinomas The present invention relates to a novel monoclonal antibody reactive with human carcinoma cells. More particularly, the antibody of the invention is a monoclonal antibody reactive with a glycolipid cell membrane antigen on the surface of human carcinomas...	09/07/1993
5236905	In vitro method of inhibition of HIV using transforming growth factor-.beta . The use of TGF-ଲ to inhibit HIV infection and/or replication is described. Both mature and precursor forms of TGF-ଲ are efficacious in inhibiting production of HIV. The TGF-ଲ used to inhibit HIV may be obtained from natural sources or ma...	08/17/1993
5221620	Cloning and expression of transforming growth factor 댢 cDNA clones coding for TGF-댢 which are used to construct expression vectors capable of directing the high-level expression of mature, biologically active TGF-댢, as well as precursor TGF-댢 forms, in transfected Chinese Hamster Ovary ce...	06/22/1993
5204244	Production of chimeric antibodies by homologous recombination A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologou...	04/20/1993
5202238	Production of chimeric antibodies by homologous recombination A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologou...	04/13/1993
5202116	Methods for controlling human endothelial cell proliferation and effector functions using oncostatin M The present invention is directed to the use of a recently discovered cytokine, Oncostatin M, to control endothelial cell immunogenicity, fibrinolytic activity and proliferation, and to its use in the treatment of a variety of human vascular and immune sy...	04/13/1993
5185432	Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas The present invention is concerned with novel monoclonal antibodies which bind strongly to a protein antigen associated with human non-small cell lung carcinomas ("NSCLC") human small cell lung carcinomas and certain other human carcinomas including many ...	02/09/1993
5171665	Monoclonal antibody to novel antigen associated with human tumors The present invention is concerned with a novel monoclonal antibody which binds strongly to a protein antigen associated with human tumors, including carcinomas of the colon and lung. The antibody binds to normal human cells to a much lesser degree than t...	12/15/1992
5141742	Vaccines against melanoma Peptides or proteins related to a melanoma associated antigen are described. These are produced in large quantities via recombinant DNA techniques and/or by chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulat...	08/25/1992
5120535	Oncostatin M and novel compositions having anti-neoplastic activity Novel compositions are provided for modulating growth, particularly of tumor cells, which compositions are combinations of Oncostatin M, and one or both of transforming growth factors or γ-interferons, or analogs thereof. In addition, a novel transformin...	06/09/1992
5115096	Amphiregulin: a bifunctional growth modulating glycoprotein A novel cell growth regulatory factor, named Amphiregulin, is described. This extremely hydrophilic glycoprotein, having a median molecular weight of 22,500 daltons, demonstrates unusual biological activity. Amphiregulin is a bifunctional cell growth regu...	05/19/1992
5093045	Biologically active lipids binding membrane receptors Neutral lipids are provided characterized by binding to phorboid and ingenoid receptors. These lipids are found in a wide variety of cellular sources as well as milk and may be isolated by specific extraction and chromatographic procedures. Depending upon...	03/03/1992
5091178	Tumor therapy with biologically active anti-tumor antibodies A method for identifying and using antibodies which are directed against tumor-associated glycolipid antigens and which are capable of activating serum complement or antibody dependent cellular cytotoxicity. These antibodies find use in the therapy of tum...	02/25/1992
5091177	Monoclonal antibodies for treatment of human non-small cell lung carcinomas The present invention is concerned with novel monoclonal antibodies which define a glycolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much le...	02/25/1992
5084560	Immunoconjugates and methods for their use in tumor therapy Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which ...	01/28/1992
5081029	Methods of adoptive immunotherapy for treatment of aids Immunotherapeutic methods for the treatment of patients infected with the AIDS virus are described. T lymphocytes which are histocompatible with the patient and specific for the AIDS virus are activated in vitro by exposure to AIDS virus-related epitopes....	01/14/1992
5077312	Biologically active lipids binding membrane receptors Neutral lipids are provided characterized by binding to phorboid and ingenoid receptors. These lipids are found in a wide variety of cellular sources as well as milk and may be isolated by specific extraction and chromatographic procedures. Depending upon...	12/31/1991
5055559	Anti-melanoma antibody MG-21 for diagnosis and therapy of human tumors An antibody MG-21 which is directed against a tumor-associated glycolipid antigen and which is capable of activating serum complement or antibody dependent cellular cytoxicity is described. This antibody finds use in the therapy of cancers particularly me...	10/08/1991
5011777	Vectors encoding brain derivable polypeptide factors Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The low molecular weight polypeptides either are growt...	04/30/1991
4997913	pH-sensitive immunoconjugates and methods for their use in tumor therapy Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which ...	03/05/1991
4990289	Biologically active lipids binding membrane receptors Neutral lipids are provided characterized by binding to phorboid and ingenoid receptors. These lipids are found in a wide variety of cellular sources as well as milk and may be isolated by specific extraction and chromatographic procedures. Depending upon...	02/05/1991
4935495	Monoclonal antibodies to the L6 glycolipid antigenic determinant found on human non-small cell lung carcinomas The present invention is concerned with novel monoclonal antibodies which define a gylcolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much le...	06/19/1990
4918164	Tumor immunotherapy using anti-idiotypic antibodies The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T l...	04/17/1990
4906562	Monocolonal antibodies and antigen for human non-small cell lung carcinomas The present invention is concerned with novel monoclonal antibodies which define a glycolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much le...	03/06/1990
4873188	Method, monoclonal antibody, and monoclonal antibody fragments for detecting human non-small cell lung carcinomas and cell line for producing such antibodies The present invention is concerned with two novel monoclonal antibodies which define carbohydrate antigens associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a mu...	10/10/1989
4774318	Snake venom growth arresting peptide Novel cytotoxic agents are provided as small polypeptides related to a low molecular weight peptide derived from Crotalus atrox. The compounds may be used by themselves or in combination with other reagents, such as antibodies, for inhibiting cell growth....	09/27/1988
4737580	Platelet related growth regulator Novel polypeptide compositions are provided which inhibit human tumor cell growth, which may or may not stimulate autophosphorylation of pp60 src and induce the release of a 52kDal polypeptide from neoplastic cells. Individual polypeptides may be isolated...	04/12/1988
4737579	Monoclonal antibodies for human non-small cell lung carinomas The present invention is concerned with novel monoclonal antibodies which define antigens associated with human non-small cell lung carcinomas ("NSCLC"). The antibodies bind to normal human cells to a lesser degree than to tumor cells. The antibodies find...	04/12/1988

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Assignee: Oncogen