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| Number | Title | Issue Date |
| 7456214 | Chromene-containing compounds with anti-tubulin and vascular targeting activity Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. ... | 11/25/2008 |
| 7384925 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 06/10/2008 |
| 7358236 | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents The present invention provides a method of using anti-hypertensive agents (“AHAs”) to attenuate the transient increase in blood pressure observed in patients where Vascular Targeting Agents (“VTAs”) are administered to treat diseases associated with malignan... | 04/15/2008 |
| 6956054 | Compositions and methods for use in targeting vascular destruction Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels a... | 10/18/2005 |
| 6773702 | Use of combretastatin A4 and its prodrugs as an immune enhancing therapy A method of treating immune suppression in a warm-blooded animal bearing a tumor, by administering to the animal an amount of combretastatin A4 and/or a prodrug thereof effective to enhance immune responsiveness without causing vascular destruction. Immunotherapy tr... | 08/10/2004 |
