Assignee: OSI Pharmaceuticals, Inc.

Location: Melville, NY
No. of patents: 58

Number	Title	Issue Date
7790902	Isothiazole derivatives useful as anticancer agents The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3	09/07/2010
7741324	Imidazotriazines as protein kinase inhibitors Compounds of the formula and pharmaceuticaly acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various dise...	06/22/2010
7700594	Fused bicyclic mTOR inhibitors Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer. ...	04/20/2010
7696225	(2-carboxamido)(3-Amino) thiophene compounds Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer. ...	04/13/2010
7662844	Naphthylene derivatives as cytochrome P450 inhibitors Compounds of the formula and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G1, Q1, Z, R1, R2, R3, R4a, R	02/16/2010
7659274	Unsaturated mTOR inhibitors Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer. ...	02/09/2010
7651687	Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors The present invention provides a method for treating NSCL, pancreatic, colon or breast cancer tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of a combination of an EG...	01/26/2010
7648987	Bicyclic protein kinase inhibitors Compounds of the Formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are d...	01/19/2010
7645754	Pyrrolopyrimidine Aselective antagonist compounds, their synthesis and use The subject invention provides compounds having the structure: wherein, R1 is a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihyd...	01/12/2010
RE41065	Alkynl and azido-substituted 4-anilinoquinazolines The invention relates to compounds of the formula and to pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, n and m are as defined herein. The compounds of formula I are...	12/29/2009
7618965	(Arylamidoanilino)nitroethylene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R1, R2, and R5 are defined herein, are useful in the treatment of tumors and ...	11/17/2009
7608577	Peptidyl ketones as inhibitors of DPIV The present invention relates to compounds of the general formula 1 and pharmaceutically acceptable salts thereof, to the use of the compounds for the treatment of impaired glucose tolerance, glucosuria, hyperlipidaemia, me...	10/27/2009
7598252	Compounds specific to adenosine A, receptors and uses thereof This invention pertains to compounds which specifically inhibit the adenosine A1 receptor and the use of these compounds to treat a disease associated with A1 adenosine receptors in a subject. ...	10/06/2009
7566721	Substituted thienol[2,3-d]pyrimidines as kinase inhibitors Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment a...	07/28/2009
7534797	6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1...	05/19/2009
7524859	(2-carboxamido)(3-amino)thiophene compounds A method of treatment of hyperproliferative disorders comprises a step of administering an effective amount of a compound represented by ...	04/28/2009
7524638	Methods for identification of modulators of OSGPR114 or OSGPR78 activity, and their use in the treatment of disease This invention relates to the identification of LPA as a ligand for the G-protein coupled receptors OSGPR114 and OSGPR78. The invention is directed to new methods for screening candidate drugs for their ability to modulate the activity of OSGPR114 or OSGPR78, and ne...	04/28/2009
7521456	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate The present invention relates to the anhydrous and hydrate forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate. The invention also relates to pharmaceutical compositions containing N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazoli...	04/21/2009
7521448	N-substituted benzimidazolyl c-Kit inhibitors Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer. ...	04/21/2009
7504407	Compounds specific to adenosine Aand Areceptors and uses thereof This invention pertains to compounds having the structure: wherein m is 0, 1, 2, or 3; R2 is a substituted or unsubstituted imidazole or pyrazole wherein the po...	03/17/2009
7501407	Pyrimidine Aselective antagonist compounds, their synthesis and use The subject invention provides compounds having the structure: wherein R1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5 heteroatoms; R2	03/10/2009
7498354	Pyrrolo[2,3-D]imidazoles for the treatment of hyperproliferative disorders or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers. ...	03/03/2009
7485658	N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer. ...	02/03/2009
7465726	Substituted pyrrolo[2.3-B]pyridines Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, ...	12/16/2008
7459554	Imidazopyrazine tyrosine kinase inhibitors Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various dis...	12/02/2008
7442709	N3-substituted imidazopyridine c-Kit inhibitors Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer. ...	10/28/2008
7419995	N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazol...	09/02/2008
7405218	Isothiazole derivatives useful as anticancer agents The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein....	07/29/2008
7405210	Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, ...	07/29/2008
7388012	(Hydrazido)(amino)thiophene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, ...	06/17/2008
7160890	Compounds specific to adenosine Areceptor and uses thereof This invention pertains to compounds which specifically inhibit the adenosine A3 receptor and the use of these compounds to treat a disease associated with A3 adenosine receptor in a subject, comprising administering to the subject a therapeuti...	01/09/2007
7115647	Method of inhibiting neoplastic cells with indole derivatives A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives. ...	10/03/2006
7101893	(2-Carboxamido)(3-amino)thiophene compounds A method of treatment of hyperproliferative disorders comprises administering an effective amount of a compound represented by Formula II: or a pharmaceutically acceptable salt thereof. ...	09/05/2006
7087613	Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride A method of monotherapy for a subject suffering from abnormal cell growth expressing the epidermal growth factor receptor (EGFR) which comprises orally administering to the subject a therapeutically effective amount of a crystalline polymorph of the hydrochloride sa...	08/08/2006
7064122	Pancreatic lipase inhibitor compounds, their synthesis and use The subject invention features compounds having the structure: wherein X is O, S, CH2 or NR5; Y is O or S; R1 is H, substituted or unsubstituted C1-C15 alkyl, C	06/20/2006
6916804	Pyrimidine A2b selective antagonist compounds, their synthesis and use The subject invention provides compounds having the structure: wherein R1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5 heteroatoms; R	07/12/2005
6900221	Stable polymorph on N-(3-ethynylphenyl)-6, 7-bis (2methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof The present invention relates to a stable crystalline form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the B polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceuti...	05/31/2005
6878716	Compounds specific to adenosine A1 receptor and uses thereof This invention pertains to compounds which specifically inhibit the adenosine A1 receptor and the use of these compounds to treat a disease associated with A1 adenosine receptor in a subject, comprising administering to the subject a therapeuti...	04/12/2005
6875575	Diagnostic methods for neoplasia This invention provides a method for diagnosing a patient with neoplasia. ...	04/05/2005
6869944	Method for treating a patient with neoplasia by treatment with a platinum coordination complex This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an antineoplastic platinum coordination complex. ...	03/22/2005

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Assignee: OSI Pharmaceuticals, Inc.