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| Number | Title | Issue Date |
| 8153151 | Composition and method for controlling drug delivery from silicone adhesive blends Compositions and methods for controlling transdermal drug delivery, particularly of amine-functional and basic drugs, comprising a blend of a first silicone-based polymer having a reduced silanol concentration and a second silicone-based polymer have a substantial o... | 04/10/2012 |
| 8110565 | Enhanced drug delivery in transdermal systems A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a drug that includes a parent drug and a prodrug; and a pharmaceutically acceptable carrier, wherein the parent drug and prodrug are individually... | 02/07/2012 |
| 8025898 | Enhanced drug delivery in transdermal systems A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a drug that includes a parent drug and a prodrug; and a pharmaceutically acceptable carrier, wherein the parent drug and prodrug are individually... | 09/27/2011 |
| 7993671 | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which h... | 08/09/2011 |
| 7989496 | Transdermal delivery of ketoprofen polar derivatives A topical or transdermal composition including a polar derivative of ketoprofen and a pharmaceutically acceptable topical or transdermal carrier, wherein the polar derivative of ketoprofen comprises a polarity that is greater than that of ketoprofen. ... | 08/02/2011 |
| 7879831 | Enhanced drug delivery in transdermal systems A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a pharmaceutically active agent that includes a corresponding steroid and a steroid derivative; and a carrier for the pharmaceutically active age... | 02/01/2011 |
| 7867986 | Enhanced drug delivery in transdermal systems A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a pharmaceutically active agent that includes a corresponding steroid and a steroid derivative; and a carrier for the pharmaceutically active age... | 01/11/2011 |
| 7456159 | Enhanced drug delivery in transdermal systems A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a drug that includes a parent drug and a prodrug; and and a pharmaceutically acceptable carrier, wherein the parent drug and prodrug are individu... | 11/25/2008 |
| 7063859 | Barrier film lined backing layer composition and method for topical administration of active agents A transdermal drug delivery device for topical application of active agents is disclosed. The invention comprises the use of a flexible and soft backing layer, in particular a cellular foam, having an inner surface and an outer surface, wherein an impermeable polyme... | 06/20/2006 |
| 7044301 | Product positioning retention package A product retention package is disclosed, wherein the package is configured to form a sealed internal cavity for receiving a product, particularly transdermal delivery systems, patches, bandages, films, sheets, and the like. A retention apparatus is formed in associ... | 05/16/2006 |
| 6905016 | Packaging system for transdermal drug delivery systems A device and method for stabilizing a drug, particularly a chiral drug or the active enantiomer(s) thereof, in a carrier composition of a transdermal delivery system prior to the systems use by providing a product packaging system to prevent or control degradation r... | 06/14/2005 |
| 6851615 | Method of individually tracking and identifying a drug delivery device A method of and system for identifying an individual drug delivery device and tracing its ownership. An individual drug delivery device, such as a patch, is coded with a unique identifier. Such coding is performed by using a bar code or by storing the identifier in ... | 02/08/2005 |
| 6805878 | Transdermal administration of ACE inhibitors Disclosed is a dermal composition comprising enalapril ethyl ester or another prodrug corresponding to a pharmaceutically active form of an ACE inhibitor in an amount corresponding to a therapeutically effective amount of enalaprilat (or other pharmaceutically activ... | 10/19/2004 |
| 6638528 | Compositions and methods to effect the release profile in the transdermal administration of active agents Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides ... | 10/28/2003 |
| 6562363 | Bioadhesive compositions and methods for topical administration of active agents Bioadhesive compositions in a flexible, finite form for topical application to skin or mucous membranes comprising a composition which results from an admixture of at least one PVP polymer, at least one bioadhesive, optionally a pharmaceutically acceptabl... | 05/13/2003 |
| 6465004 | Solubility enhancement of drugs in transdermal drug delivery systems and methods of use A composition and method for the continuous and controlled transdermal delivery of an active agent comprising a pharmaceutically acceptable active agent carrier and cellulose derivative which provides a solubilizing and stabilizing effect on the active ag... | 10/15/2002 |
| 6348211 | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate The invention relates to a method of treating Attention Deficit Disorder (ADD) and Attention Deficit/Hyperactivity Disorder (ADHD) and compositions for topical application of methylphenidate comprising methylphenidate in a flexible, finite system wherein ... | 02/19/2002 |
| 6316022 | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liqu... | 11/13/2001 |
| 6261405 | Method and apparatus for making a patch A method and apparatus for making a patch comprising a foam supplier for supplying a foam backing having a predetermined porosity, a dispensing device for applying an ointment to the foam backing in a predetermined pattern, and a cooling device for coolin... | 07/17/2001 |
| 6235306 | Solubility parameter based drug delivery system and method for altering drug saturation concentration The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in ... | 05/22/2001 |
| 6221383 | Solubility parameter based drug delivery system and method for altering drug saturation concentration A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pres... | 04/24/2001 |
| 6210705 | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate The invention relates to a method of treating Attention Deficit Disorder (ADD) and Attention Deficit/Hyperactivity Disorder (ADHD) and compositions for topical application of methylphenidate comprising methylphenidate in a flexible, finite system wherein ... | 04/03/2001 |
| 6159497 | Patch applicator A patch applicator for easy application of a transdermal patch is disclosed, wherein the applicator is especially suitable for a small transdermal patch of size 20 cm2 or less. The patch applicator includes a rigid release liner and a flexible ... | 12/12/2000 |
| 6024976 | Solubility parameter based drug delivery system and method for altering drug saturation concentration A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pres... | 02/15/2000 |
| 6024974 | Composition and methods for transdermal delivery of acid labile drugs A transdermal composition and related method are described. Specifically, the transdermal composition is substantially free of gestodene or substantially free of isopropyl myristate and substantially free of lower alkanols and comprises: (a) a therapeutic... | 02/15/2000 |
| 5958446 | Solubility parameter based drug delivery system and method for altering drug saturation concentration The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in ... | 09/28/1999 |
| 5725876 | Compositions and methods for using low-swell clays in nicotine containing dermal compositions A dermal composition for transdermal administration of nicotine includes a blend of: one or more acrylic-based polymers in an amount of from about 10-90% w/w, nicotine in an amount of from about 3 to 15% w/w, and a cohesiveness increasing amount of one or... | 03/10/1998 |
| 5719197 | Compositions and methods for topical administration of pharmaceutically active agents Compositions for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a pharmaceutically acceptable bioadhesive carrier, a solvent for the pharmaceutical agent(s) in the carrier and a clay, and methods of adminis... | 02/17/1998 |
| 5686099 | Method and device for the release of drugs to the skin A method of increasing the adhesiveness of a shaped pressure sensitive adhesive, comprising adding an adhesiveness and drug release increasing amount of a clay to said adhesive prior to casting of the adhesive. A dermal composition comprising a drug, a pressur... | 11/11/1997 |
| 5656286 | Solubility parameter based drug delivery system and method for altering drug saturation concentration A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pres... | 08/12/1997 |
| 5656285 | Method for forming a transdermal drug device Disclosed is a method and apparatus for forming a transdermal drug delivery device from a multilayer web comprised of a backing layer, a drug-containing pressure sensitive adhesive layer, and a release layer or liner in which cutting is progressively achi... | 08/12/1997 |
| 5474783 | Solubility parameter based drug delivery system and method for altering drug saturation concentration The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in ... | 12/12/1995 |
| 5405486 | Apparatus for forming a transdermal drug device Disclosed is a method and apparatus for forming a transdermal drug delivery device from a multilayer web comprised of a backing layer, a drug-containing pressure sensitive adhesive layer, and a release layer or liner in which cutting is progressively achi... | 04/11/1995 |
| 5332576 | Compositions and methods for topical administration of pharmaceutically active agents A composition for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a flexible, finite, pharmaceutically acceptable, bioadhesive carrier, and a solvent for the pharmaceutical agent(s) in the carrier and a meth... | 07/26/1994 |
| 5300291 | Method and device for the release of drugs to the skin A method of increasing the adhesiveness of a shaped pressure sensitive adhesive, comprising adding an adhesiveness and drug release increasing amount of a clay to said adhesive prior to casting of the adhesive. A dermal composition comprising a drug, a pressur... | 04/05/1994 |
| 5234957 | Compositions and methods for topical administration of pharmaceutically active agents A composition for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a flexible, finite, pharmaceutically acceptable, bioadhesive carrier, and a solvent for the pharmaceutical agent(s) in the carrier and a meth... | 08/10/1993 |
| 5032207 | One-step method for forming a pressure-sensitive adhesive transdermal drug device A one step method and apparatus for forming a pressure sensitive adhesive transdermal drug device having a scored release liner which comprises positioning a web containing the release liner using a cutting die having a first cutting element designed to c... | 07/16/1991 |
| 5006108 | Apparatus for iontophoretic drug delivery An iontophoretic device for delivery of a drug comprising a flexible, non-conductive backing; first and second conductive electrodes composed of a substantially non-ionizing material in a plane, one side of the plane which is optionally attached to the op... | 04/09/1991 |
| 4994267 | Transdermal acrylic multipolymer drug delivery system A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, ... | 02/19/1991 |
| 4994278 | Breathable backing A composition comprising a flexible backing for a transdermal drug preparation with a water vapor transmission rate about equal to or in excess of that of ethylene vinyl alcohol copolymer, namely equal to or in excess of, at one mil thickness, of about 2 ... | 02/19/1991 |
