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Assignee: Novartis Finance Corporation


Location: NewYork, NY
No. of patents: 117

1      
NumberTitleIssue Date
6632981DNA sequences encoding polypeptides having beta-1,3-glucanase activity
The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chime...
10/14/2003
6410329Method for achieving site specific integration of exogenous DNA delivered by non-biological means to plant cells
The present invention provides an improved method of site directed integration of an exogenous DNA molecule by co-delivery of a gene of interest flanked by nucleotide sequences recognized by a recombinase and a mRNA encoding the homologous recombinase....
06/25/2002
6308458Herbicide-tolerant plants and methods of controlling the growth of undesired vegetation
The present invention relates to methods for controlling the growth of undesired vegetation comprising applying an effective amount of a protox-inhibiting herbicide to a population of transgenic plants or plant seed transformed with a DNA sequence coding ...
10/30/2001
6300519Antivirally active heterocyclic azahexane derivatives
There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or more ...
10/09/2001
6282837Methods of controlling the growth of undesired vegetation with herbicide tolerant plants or plant seeds having altered protoporphyrinogen oxidase activity
The present invention provides novel eukaryotic DNA sequences coding for native protoporphyrinogen oxidase (protox) or modified forms of the enzyme which are herbicide tolerant. A method for controlling weeds using plants having altered protox activity wh...
09/04/2001
6262342DNA sequences encoding polypeptides having ଲ-1,3-glucanase activity
The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chime...
07/17/2001
6232525Mutant plants and uses therefor
Methods are provided for selecting parental plants exhibiting disease resistance and for using these plants in breeding programs. In one method of the invention, constitutive immunity (cim) mutants are screened for either resistance to a pathogen of inter...
05/15/2001
6201169Transformation of hereditary material of Brassica plants and cells
A novel process for the direct transfer of foreign genes to plant genomes is described. The novel process comprises placing a gene under the control of plant expression signals and transferring it, by contact with protoplasts without the aid of natural sy...
03/13/2001
6177245Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms
The present invention provides novel eukaryotic DNA sequences coding for native protoporphyrinogen oxidase (protox) or modified forms of the enzyme which are herbicide tolerant. Plants having altered protox activity which confers tolerance to herbicides a...
01/23/2001
6166004Combinations of HIV protease inhibitors with reverse transcriptase inhibitors
There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or ...
12/26/2000
6153374Method for identifying inhibitors of soraphen A resistant acetyl-coenzyme a carboxylase
An assay to identify inhibitors of soraphen A resistant acetyl-coenzyme A carboxylase comprising measuring the reactivity of acetyl-coenzyme A carboxylase in the presence and in the absence of a compound suspected to inhibit soraphen A resistant acetyl-co...
11/28/2000
6150585Nucleic acids encoding tospovirus genome and expression thereof
Recombinant DNA constructs comprising a DNA coding for transcription into an RNA sequence of tospoviruses or into RNA sequences related thereto, the use of such DNA constructs to transform plants having reduced susceptibility to tospovirus infection and p...
11/21/2000
6147282Method of controlling the fertility of a plant
The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression cassettes and at least one target expression cassette. The fir...
11/14/2000
6137033Class of proteins for the control of plant pests
The genes encoding a novel class of insectecidal proteins have been isolated and characterized from a strain of Bacillus thuringiensis. Both the nucleic and amino acid sequences for the proteins are disclosed. The nucleic acid molcules are utilized in the...
10/24/2000
6133417Cytochrome P-450 monooxygenases
New cytochrome P-450 dependent monooxygenases and DNA molecules encoding these monooxygenases are provided, which are able to catalyze the biosynthetic pathway from amino acids to their corresponding cyanohydrins, the presursors of the cyanogenic glycosid...
10/17/2000
6130236Pesticidal compositions
The present invention relates to novel crop-protecting active ingredient mixtures having synergistically enhanced action, comprising at least two active ingredient components together with a suitable carrier, wherein component I is 1-[[2-(2,4-dichoropheny...
10/10/2000
6124493Process for the preparation of o-chloromethyl-phenylglyoxylic acid derivatives
There is described a process for the preparation of a compound of formula I ##STR1## in which process: a) a compound of formula II ##STR2## is reacted with an organolithium compound of formula III Li--R7 ...
09/26/2000
6121014Method for producing a plant-optimized nucleic acid coding sequence
DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-pr...
09/19/2000
6117670Pyrrolnitrin biosynthesis genes and uses thereof
The present invention is directed to the production of pyrrolnitrin in a host via recombinant expression of the polypeptides needed to biologically synthesize pyrrolnitrin. Genes isolated from P. fluorescens, P. pyrrocinia, B. cepacia, and M. fulvus that ...
09/12/2000
6107544Method for breeding disease resistance into plants
Methods are provided for selecting parental plants exhibiting disease resistance and for using these plants in breeding programs. In one method of the invention, constitutive immunity (cim) mutants are screened for either resistance to a pathogen of inter...
08/22/2000
6107279Class of proteins for the control of plant pests
The genes encoding a novel class of insecticidal proteins have been isolated and characterized from a strain of Bacillus thuringiensis. Both the nucleic and amino acid sequences for the proteins are disclosed. The nucleic acid molecules are utilized in th...
08/22/2000
6091004Gene encoding a protein involved in the signal transduction cascade leading to systemic acquired resistance in plants
The invention concerns the location and characterization of a gene (designated NIM1) that is a key component of the SAR pathway and that in connection with chemical and biological inducers enables induction of SAR gene expression and broad spectrum diseas...
07/18/2000
6075185Synthetic DNA sequence having enhanced insecticidal activity in maize
DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-pr...
06/13/2000
6071698DNA extraction buffer and method of use thereof
Internal Transcribed Spacer (ITS) DNA sequences from the ribosomal RNA gene region are described for different species and strains of Helminthosporium carbonum, Helminthosporium turcicum, Helminthosporium maydis, Cercospora zeae-maydis, Kabatiella zeae an...
06/06/2000
6069301Antibodies which bind to insect gut proteins and their use
Antibodies, monoclonal antibodies or fragments thereof which bind to brush border membrane vesicles of insect gut and the gene or genes which encode these proteins are provided. The monoclonal antibodies bind the gut of a target insect but do not bind to ...
05/30/2000
6066783Genes encoding insecticidal proteins
The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequen...
05/23/2000
6057490Method for selecting disease resistant mutant plants
Methods are provided for selecting parental plants exhibiting disease resistance and for using these plants in breeding programs. In one method of the invention, constitutive immunity (cim) mutants are screened for either resistance to a pathogen of inter...
05/02/2000
6054637Signal sequences for vacuolar sorting
The present invention relates to novel peptide fragments [targeting signal] that are obtainable from the C-terminal region [C-terminal extension] of plant vacuole proteins and that, in operable linkage with any desired protein molecule, ensure that the pr...
04/25/2000
6051409Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
The present invention provides an improved method for achieving stable integration of an exogenous DNA fragment in intact form into the genome of a eukaryotic cell, particularly a plant cell. The method comprises providing the exogenous DNA together with ...
04/18/2000
6051760Synthetic DNA sequence having enhanced insecticidal activity in maize
DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-pr...
04/18/2000
6040496Use of translationally altered RNA to confer resistance to maize dwarf mosaic virus and other monocotyledonous plant viruses
The present invention provides methods and compositions for inhibiting virus infection in susceptible monocotyledonous plants. The methods and compositions involve the production of translationally altered forms of messenger RNA sequence derived from the ...
03/21/2000
6040504Cotton promoter
A promoter isolated from a cotton gene encoding the small subunit of ribulose bisphosphate carboxylase is described. The isolated promoter is operably linked to a coding sequence of interest to make a chimeric gene....
03/21/2000
6023012DNA molecules encoding plant protoporphyrinogen oxidase
The present invention provides novel DNA sequences isolated from soybean, wheat, cotton, sugar beet, rape, rice, sorghum, and sugar cane that coding for enzymes having protoporphyrinogen oxidase (protox) activity. In addition, the present invention teache...
02/08/2000
6017850Herbicidal composition and method of weed control
A herbicidal composition comprising, in addition to customary inert formulation adjuvants, as active ingredient a) an antagonistically active amount of at least one compound A selected from the group of compounds of formula A1 ##STR1## and...
01/25/2000
6018679Iontophoretic transdermal delivery and control of adverse side-effects
A method is disclosed for iontophoretically removing any compound that is capable of causing skin irritation or other harmful effects. More specifically, a bipolar iontophoretic transdermal delivery method is disclosed that includes a reversal phase for c...
01/25/2000
6018099Tissue-preferential promoters
DNA sequences are able to function as promoters of tissue-preferential transcription of associated DNA sequences in plants, particularly in the roots. These DNA sequences can be used in transformation vectors to produce transgenic plants which will expres...
01/25/2000
6018103Chimeric plant genes possessing independent regulatory sequences
The present invention relates to a chimeric gene construction comprising one promoter element and a 3' termination signal in functional combination with a gene, wherein a) the promoter is an snRNA promoter element from plants specific for RNA polymerase I...
01/25/2000
6018104Nucleic acid promoter fragment isolated from a plant tryptophan synthase alpha subunit (trpA) gene
DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-pr...
01/25/2000
6018105Promoters from plant protoporphyrinogen oxidase genes
Promoters naturally associated with plant protoporphyrinogen oxidase (protox) coding sequences, and derivatives thereof, are provided. These promoters can be used to control the expression of an operably linked heterologous coding sequence in a plant cell...
01/25/2000
6002068Methods for conferring insect resistance to a monocot using a perioxidase coding sequence
The present invention relates, in general, to methods and compositions for controlling insects in monocotyledonous plants (monocots), particularly maize. More precisely, the present invention relates to (1) a method for controlling insects comprising feed...
12/14/1999
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