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Vehicular Impact Signaling Device
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| Number | Title | Issue Date |
| 7749526 | Vermin-repellant compositions and compounds Compounds of formula (I) are described for deterring vermin, wherein R is unbranched or branched C1-C15 alkyl, which is unsubstituted or substituted by halogen, cyano or nitro; R1 and R2 are unbranched or branched C1-C12 a... | 07/06/2010 |
| 7748377 | Methods and systems for operating an aerosol generator A nebulized fluid, generated by vibrating an aerosolization element, is introduced into a breathing circuit during a certain interval of a patient's breathing cycle. In some embodiments, the fluid comprises an antibiotic that is selected to treat a pulmonary infecti... | 07/06/2010 |
| 7745462 | Quinoline-2-one derivatives for the treatment of airways diseases Compounds of formula I in free or salt form, wherein —C—Y—, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviate... | 06/29/2010 |
| 7744785 | Method for preparing silicone hydrogels The present invention provides a method and a formulation for consistently producing a silicone hydrogel material having relatively high oxygen permeability, relatively high ion permeability, and low modulus, and contact lenses prepared from a formulation of the inv... | 06/29/2010 |
| 7741338 | Macrolides The invention relates to the stabilization of poly-ene macrolides and to a particular macrolide obtained in crystalline form. ... | 06/22/2010 |
| 7740843 | Human monoclonal antibodies against human IL-4 Antibodies which are specific for human interleukin-4 and their use in the treatment of IL-4 and/or IgE mediated diseases. ... | 06/22/2010 |
| 7740842 | Stable liquid formulations of antibodies The present invention provides stable liquid formulations of antibodies suitable for parenteral administration. Also, provided are aqueous solutions which have high concentrations of therapeutical antibodies which may be used to produce therapeutical liquid formulat... | 06/22/2010 |
| 7732603 | Organic compounds as agents for the treatment of aldosterone mediated conditions Compounds of formula I provide pharmacological agents which are inhibitors of the P450 enzyme, aldosterone synthase, and thus may be employed for the treatment of aldosterone mediated conditions. Accordingly, the compounds ... | 06/08/2010 |
| 7732435 | Chromone derivatives useful as antagonists of VR1 receptors The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to ... | 06/08/2010 |
| 7732134 | Methods to predict cholesterol elevation during immunosuppressant therapy This invention provides methods to predict the degree of elevation of serum cholesterol levels in patients treated with immunosuppressive medication. This invention also provides treatment strategies based on these predictions and kits to carry out these methods. | 06/08/2010 |
| 7731978 | Mutant forms of streptolysin O Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S. pyogenes. ... | 06/08/2010 |
| 7728024 | Metal salts of 2′-(1H-Tetrazol-5yl)-1.1′-biphenyl-4-carboxaldehyde The invention relates to a method or process for the manufacture of blood pressure lowering agents, such as valsartan, novel intermediates as well as process steps in said synthesis. The method or process leads via the novel intermediate salts of the formula IA,... | 06/01/2010 |
| 7728020 | Amino acid derivatives The present invention relates to new amino acid derivatives, process for the production, their use, in particular in transplantation, and pharmaceutical compositions containing them. ... | 06/01/2010 |
| 7726237 | Printing apparatus for making colored contact lenses A printing station for producing a layer of coloring for a contact lens, comprising a transport system to carry and transport a molding tool which comprises at least one contact lens forming mold, a pad unit comprising at least one pad, and a blade unit suitable to ... | 06/01/2010 |
| D616993 | Portable-electronic device | 06/01/2010 |
| 7723550 | Process for preparing organic compounds Process for preparing a compound of the formula (I) in which R1 and R2 are each independently H, C1-C8-alkyl, halogen, polyhalo-C1-C8-alkoxy, polyhalo-C1-C8-alkyl, C1-... | 05/25/2010 |
| 7723402 | Ink formulations and uses thereof The present invention provides a chemical ink comprises a solvent, a binder polymer, a colorant and optionally a crosslinker. The ink of the invention has one or more of the following characteristics: a viscosity lower than about 50 centipoises; a surface tension of... | 05/25/2010 |
| 7723356 | Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists Compounds of Formula (I); in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, espe... | 05/25/2010 |
| 7723339 | Combination comprising a signal transduction inhibitor and an epothilone derivative The present invention relates to a combination comprising N-{5-[4-(4-methyl-piperazino-methyl) -benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and an epothiione derivative; pharmaceutical composition comprising said combination; method of treatment c... | 05/25/2010 |
| 7722869 | Antibody molecules and nucleic acids An scFv peptide comprising a VH domain and a VL domain linked by an amino acid spacer is disclosed. The VH domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 64. The VL domain com... | 05/25/2010 |
| 7722808 | Method and kits for sterilizing and storing soft contact lenses The present invention provides a method and a container for sterilizing a soft contact lens and for providing a sterilized storage package of the soft contact lens maintained in a packaging solution. By using the method and container of the invention, deformations o... | 05/25/2010 |
| 7718632 | RNAi inhibition of alpha-ENaC expression The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides. ... | 05/18/2010 |
| 7713991 | Imidazo[[1, 5-A] pyridine derivatives and methods for treating aldosterone mediated diseases Compounds of the formula (I) provide pharmacological agents which are inhibitors of the P450 enzyme, aldosterone synthase, and thus may be employed for the treatment of aldosterone mediated conditions. Accordingly, the comp... | 05/11/2010 |
| 7713977 | (1-aza-bicyclo[3.3.1]non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-achr for the treatment of psychotic and neurodegenerative disorders The present invention relates to compounds of formula (I) wherein n represents 0, 1, 2, 3, 4 or 5 R represents independent from each other hydroxyl, cyano, nitro, halogen, alkyl, alkoxy alkylcarbon... | 05/11/2010 |
| 7713976 | [(1H-indol-5-yl)-heteroaryloxy]-1-aza-bicylco[3.3.1]nonanes as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I) wherein the substituents are as defined in the specification and to processes for their production, their use as pharmaceuticals and to pharmace... | 05/11/2010 |
| 7709657 | Process for the synthesis of organic compounds The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): | 05/04/2010 |
| 7709532 | Methods for improving bioavailability of a renin inhibitor The present invention provides a method for improving the bioavailability of a renin inhibitor, preferably, of a δ-amino-γ-hydroxy-ω-aryl-alkanoic acid derivative, which method comprises co-administering to a mammal, especially a human, in need of such treatment,... | 05/04/2010 |
| 7709470 | 11-phenyl-dibenzodiazepine derivatives as RXR-antagonists The present invention relates to novel benzodiazepine compounds exhibiting RXR-antagonist efficacy, for delaying progression of, preventing or treating a condition or disease being associated with RXR-antagonism, in particular selected from diabetes, complication of... | 05/04/2010 |
| 7707970 | Vaccine against salmonid rickettsial septicaemia based on cells A vaccine based on live Arthrobacter cells is useful in preventing piscirickettsiosis in fish. ... | 05/04/2010 |
| D614968 | Tube and cap combination | 05/04/2010 |
| 7705067 | Biomedical device having improved surface characteristics Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, follow... | 04/27/2010 |
| 7705047 | Amidoacetonitrile derivatives The invention relates to compounds of the general formula wherein either R signifies C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C2-C6-... | 04/27/2010 |
| 7705044 | Benzamidoacetonitriles and their use as antiparasitics The invention relates to compounds of the general formula and optionally the enantiomers thereof. These compounds have advantageous pesticidal properties. They are especially suitable for controlling parasites in warm-blood... | 04/27/2010 |
| 7705037 | 1-substituted pyrrolidin-2-ones and use thereof as peptide deformylase inhibitors The present invention relates to compounds of formula (I). These compounds are a novel type of peptide deformylase (PDF) inhibitors, and are therefore of great interest especially as new antibiotics. ... | 04/27/2010 |
| 7704996 | Compounds and compositions useful as cathepsin S inhibitors The present invention relates to the use of a 2-cyanopyrimidine compound of the formula wherein R1, R2, R3 and X are as defined in the specification and in... | 04/27/2010 |
| 7700784 | Coupling reactions useful in the preparation of (1h-tetrazol-5-yl) biphenyl derivatives The present invention relates to a process for the manufacture of intermediates that may be used for the manufacture of ARBs (also called angiotension II receptor antagonists or AT1 receptor antagonists) comprising as a common structural feature a (1H-tetrazol-5-yl)... | 04/20/2010 |
| 7700656 | Organic compounds The invention relates to the use of aminoacetonitrile compounds of formula (I), wherein R1, R2, R3, R4, R8, R9, A, m and n have the significances given in claim 1, in the control of endoparasit... | 04/20/2010 |
| 7700637 | Organic compounds Compounds of the formula provide pharmacological agents which bind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the present invention are useful for the treatment of conditions media... | 04/20/2010 |
| 7700633 | Organic compounds Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be e... | 04/20/2010 |
| 7700622 | p-38 kinase inhibitors Compounds and compositions for modulating the activity of p38 kinases are provided, including p38α and p38β kinase. Methods for treating, preventing or ameliorating one or more symptoms of a p38 kinase mediated disease or disorder are also provided. ... | 04/20/2010 |
