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| Number | Title | Issue Date |
| 8183366 | Chemokine receptor antagonists A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: wherein the variants R, R9, Z, X, Q and Y are defined in the specification. ... | 05/22/2012 |
| 8183356 | Lentiviral packaging constructs The present invention provides novel lentiviral packaging constructs that are useful for the establishment of stable packaging cell lines and producer cell lines. In particular, the present invention provides novel packaging cell lines that are capable of constituti... | 05/22/2012 |
| 8183341 | Antibacterial compounds and processes for its production This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds. ... | 05/22/2012 |
| 8183281 | CXC-chemokine receptor ligands The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof. ... | 05/22/2012 |
| 8182792 | Pharmaceutical compositions A process for micronization of pharmaceutically active agents. ... | 05/22/2012 |
| 8178650 | Cyclic depsipeptides The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase. ... | 05/15/2012 |
| 8178576 | Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use Solid or semi-solid intraocular implant compositions are disclosed. The compositions contain a lipophilic compound but lack a polymeric ingredient. ... | 05/15/2012 |
| 8178566 | Crystal form of epothilone B and use in pharmaceutical compositions The invention relates to new crystal forms of epothilone B. ... | 05/15/2012 |
| 8178559 | Organic compounds 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the p... | 05/15/2012 |
| 8173689 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one addi... | 05/08/2012 |
| 8173667 | 1-aza-bicycloalkyl derivatives The present invention provides a compound of formula (I) where X, R, Y, D, A and B are as defined herein. ... | 05/08/2012 |
| 8173657 | Imidazoquinoxaline compounds as immunomodulators The invention provides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are... | 05/08/2012 |
| 8173634 | Polymorphic form of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic This invention relates to a novel crystalline form (Form A) of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this crystalline form, to processes ... | 05/08/2012 |
| 8173617 | RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma. ... | 05/08/2012 |
| 8172395 | Medical devices having antimicrobial coatings thereon The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydroph... | 05/08/2012 |
| 8168794 | Pim kinase inhibitors and methods of their use The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically accep... | 05/01/2012 |
| 8168681 | Amidoacetonitrile compounds and pesticidal composition thereof Novel amidoacetonitrile compounds are disclosed. The compounds have pesticidal properties and are suitable for controlling endoparasites on warm-blooded animals. ... | 05/01/2012 |
| 8168654 | Quinuclidine derivatives binding to mucarinic M3 receptors Compounds of formula I in salt or zwitterionic form wherein, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions tha... | 05/01/2012 |
| 8168616 | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension The invention relates to a combination comprising the renin inhibitor of formula (I) or a pharmaceutically acceptable salt thereof. ... | 05/01/2012 |
| 8168606 | RNAi inhibition of alpha-ENaC expression The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides. ... | 05/01/2012 |
| 8167940 | Aspheric toric intraocular lens An aspheric toric intraocular lens (IOL) having toricity and asphericity in a single lens. The toricity and asphericity may be provided on separate surfaces, such as an anterior surface and a posterior surface, or the toricity and asphericity may be combined onto a ... | 05/01/2012 |
| 8165823 | Pamps, pathogen associated molecular patterns A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen. ... | 04/24/2012 |
| 8163904 | Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-Benzamide Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes. ... | 04/24/2012 |
| 8163862 | Ophthalmic and otorhinolaryngological device materials Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance. ... | 04/24/2012 |
| 8163785 | Pyrazolo[5,1b]oxazole derivatives as CRF-receptor antagonists There are described 4-difluoromethoxyphenyl pyrazolo[5.1-b]oxazole derivatives of Formula I: which are useful as corticotropin releasing factor (CRF) receptor antagonists and as pharmaceuticals. ... | 04/24/2012 |
| 8163773 | Organic compounds The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compoun... | 04/24/2012 |
| 8163754 | Purine derivatives for use as adenosine A-2A receptor agonists Compounds of formula I in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adeno... | 04/24/2012 |
| 8163747 | Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the mesylate, hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crysta... | 04/24/2012 |
| 8163704 | Glycoside derivatives and uses thereof This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT)... | 04/24/2012 |
| 8163296 | Dimensional analysis of saccharide conjugates with GPC and SEC-MALS GPC (gel permeation chromatography) and size exclusion chromatography with detection by multi-angle light scattering photometry (SEC-MALS) can be used to accurately measure molecular size and molar mass, respectively, of saccharide conjugates. The invention provides... | 04/24/2012 |
| 8163285 | Nogo-A binding molecules and pharmaceutical use thereof The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant | 04/24/2012 |
| 8163206 | Method for making silicone hydrogel contact lenses The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to meth... | 04/24/2012 |
| 8162000 | Adjustable pneumatic system for a surgical machine A pneumatic system for a surgical machine includes a reservoir, first and second proportional valves, and a controller. The reservoir holds pressurized gas. The first proportional valve is located on an input side of the reservoir and allows a variable amount of pre... | 04/24/2012 |
| 8161969 | Dry powder dispersing apparatus and methods for their use The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to ... | 04/24/2012 |
| 8158609 | Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen The present invention is directed to the treatment of disorders involving the accumulation of drusen, such as dry age-related macular degeneration and geographic atrophy via administration of therapeutically effective amounts of at least one monomeric or polymeric c... | 04/17/2012 |
| 8158360 | Effects of inhibitors of FGFR3 on gene transcription Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or ad... | 04/17/2012 |
| 8158192 | Process for the coating of biomedical articles The invention relates to a process for the manufacture of a hydrophilic coating on a biomedical article, which comprises treating the biomedical article for a time period of ≦5 minutes with a solution of an organic solvent comprising a polyanionic compound with a ... | 04/17/2012 |
| 8153703 | UV/visible light absorbers for ophthalmic lens materials Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials. ... | 04/10/2012 |
| 8153674 | Organic compounds The present invention provides a compound of formula (I): said compound is inhibitor of aldosterone synthase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase. Accordingly... | 04/10/2012 |
| 8153672 | Polymorphic forms of deferasirox (ICL670A) The invention relates to crystalline forms of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid and to its amorphous form, to processes for the preparation thereof, to compositions containing the same and their uses for the manufacture of a medicament for... | 04/10/2012 |
