Assignee: Nippon Chemiphar Co., Ltd.

Location: Tokyo, JP
No. of patents: 71

Number	Title	Issue Date
8173378	Methods of using an alpha-1-adrenergic receptor having altered ligand affinity A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPC...	05/08/2012
7648999	Activator for peroxisome proliferator-activated receptor δ A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having...	01/19/2010
7402597	Activator of peroxisome proliferator-activated receptor δ A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B...	07/22/2008
7265137	Activator of peroxisome proliferator-activated re-ceptor δ A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8	09/04/2007
7253154	Substituted thiazolopyrimidines as xanthine oxidase inhibitors The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which m...	08/07/2007
7078422	Activator for peroxisome proliferator-activated receptor A phenylacetic acid derivative represented by the general formula (II) (wherein R11 and R12 each represents hydrogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl substituted by one to three halogen atoms, an optionally ...	07/18/2006
6787552	PPAR delta activators Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 ...	09/07/2004
6706705	Quinazoline derivatives The present invention provides a new compound which shows slow and continuous blood pressure reducing action and is useful as an antihypertensive agent. The invention resides in a quinazoline derivative of the following formula (I) and its pharmaceutically ac...	03/16/2004
6689785	Epoxysuccinamide derivatives Novel epoxysuccinamide derivatives represented by the general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R1 and R3 are each hydrogen, al...	02/10/2004
6387908	Epoxysuccinamide derivatives Epoxysuccinamide derivatives of the formula (1): ##STR1## wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; R2 is alkyl, alkenyl, alkynyl, aryl, or aralkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, aryl, a...	05/14/2002
6197937	Modified low density lipoprotein receptor The present invention provides a DNA sequence essentially encoding a mammalian vascular endothelial receptor for modified low-density lipoprotein. The sequence is set forth in the Sequence No. 1, 2 or 3....	03/06/2001
6150363	Dihydrophenazinecarboxylic acid derivatives Dihydrophenazinecarboxylic acid derivatives of the formula (I) wherein R1 represents hydrogen, linear or branched alkyl, etc., each of R2 and R3 represents hydrogen, 3-methyl-2-butenyl, etc., and each of R4 and ...	11/21/2000
6121288	Visceral fat lowering agent Methods for decreasing visceral fat, inhibiting accumulation of visceral fat and improving the distribution of visceral fat all include the administration of a thiazolidine derivative represented by formula (IV), ##STR1## wherein A3 repres...	09/19/2000
6111115	Preparation of 2-(10,11-dihydro-10-oxodibenzo-[b,f]thiepin-2-yl) propionic acid A process for preparation of 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid (i.e., Zaltoprofen) is performed by subjecting 2-(4-amino-3-carboxy-methylphenyl)propionic acid or its salt to diazotization and subsequent reaction with thio...	08/29/2000
6054437	Method for inducing death of neoplastic cells using piperazine derivatives A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a ...	04/25/2000
5962260	Recombinant production of human and bovine receptors for modified low-density lipoprotein cDNAs encoding the human and bovine vascular endothelial receptors for modified low-density lipoprotein are provided. Also described are corresponding expression vectors, their use in the recombinant production of the encoded receptors, and the receptor p...	10/05/1999
5859013	Method for inducing death of neoplastic cells using piperazine derivatives A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a ...	01/12/1999
5852006	N-aminoalkyl-substituted nitrogen-containing six membered heterocyclic compounds Disclosed are new alkylenediamine derivatives of the following formula which are effective for treatment of dysuria are disclosed: ##STR1## wherein R1 is hydrogen, alkyl, or a substituted or unsubstituted phenyl, naphthyl or aromatic heter...	12/22/1998
5843992	Epoxysuccinic acid derivatives An epoxysuccinic acid derivative having the following formula: ##STR1## wherein R1 is hydrogen, alkyl, aryl, or aralkyl; each of R2 and R3 independently is aryl, aralkyl or alkyl; X is --O-- or --NR4 --; ...	12/01/1998
5773437	Alkylenediamine derivatives The present invention relates to alkylenediamine derivatives which relieve urinating contraction and therefore are of value as active ingredients of therapeutic agents for treating dysuria....	06/30/1998
5733911	Method for inducing death of neoplastic cells using piperazne derivatives A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a ...	03/31/1998
5693651	Quinoline derivatives The invention has an object to provide a novel quinoline derivative of the following formula (I) which has no benzyl group in the 5-position and shows hypoglycemic effect, particularly, by oral administration: ##STR1## in which R1 is hydro...	12/02/1997
5576341	2-[[2-(N-isobutyl-N-methyl)amino]benzylsulfinyl]-benzimidazole as antimicrobial agent 2-[[2-(N-Isobutyl-N-methyl)amino]benzylsulfinyl]benzimidazole is effective for treating or preventing Helicobacter infections by administration to patients suffering from the infection....	11/19/1996
5574030	N-aminoalkyl-substituted nitrogen-containing five membered heterocyclic compounds Disclosed are new alkylenediamine derivatives of the following formula which are effective for treatment of dysuria are disclosed: ##STR1## wherein R1 is hydrogen, alkyl, or a substituted or unsubstituted phenyl, naphthyl or aromatic heter...	11/12/1996
5523317	Method of reducing blood pressure Disclosed is a method of reducing blood pressure which comprises administering to a patient an imidazole derivative of the formula: ##STR1## wherein: each of R1 and R2 is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl...	06/04/1996
5446146	Piperazine derivative having substituted phenyl groups A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the...	08/29/1995
5382689	Process for preparation of bevantolol hydrochloride Disclosed is a new process for preparing bevantolol hydrochloride suitable for industrial production in which bevantolol hydrochloride can be obtained in a high yield and HVA of an expensive material can be recovered. The process for the preparation of be...	01/17/1995
5349050	Peptides, and antidementia agents containing the same Disclosed is a novel peptide having one of the formulae: ##STR1## (A and B are the amino acids: wherein if A is D- or L-Pro, B is Hat or Cit; if A is D-Pro, B is D-Arg, and if B is D- or L-Arg, A is Sat, Pip, Aze or Arg) Asn-A-L- (D-)Pro-Arg- (Gly)n (A is...	09/20/1994
5312811	Peptide derivatives and antidemetia agents A novel peptide derivative having the formula: ##STR1## wherein A between Pro and Q2 is Arg or Lys: Q1 is pGlu or H; Q2 is --Gly--OH or OH; Y1 is H or --CO--T and Y2 is OH or T; wherein T is a th...	05/17/1994
5310902	Alkylenediamine derivatives Novel alkylenediamine derivatives effectively employable glutamate blockers have the formula (I) or (II): ##STR1## wherein each of R1 and R6 is an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aryl group, or an...	05/10/1994
5294439	Stabilized benzimidazole derivative and composition A stabilized physiologically active benzimidazole derivative having the formula (I): ##STR1## wherein R1 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a fluoroalkyl group having 1 to 6 carbon atoms, a cycloalkyl group, ...	03/15/1994
5250546	Amino-alcohol derivatives and processes for their preparation Amino-alcohol derivatives of the formula, ##STR1## where R1 is a straight or branched alkyl group having 3 to 8 carbon atoms, R2 and R3 are each a lower alkyl group, or R2 and R3 form a 5- to 7-m...	10/05/1993
5183811	Glycerol derivative and anti-hypertensive agent A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R1 is an alkyl group having 10-22 carbon atoms, R2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloa...	02/02/1993
5180836	Imidazole derivatives Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R1 and R2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R1 and R2 are combined to form a heterocycli...	01/19/1993
5180712	Petide antidementia and nootropic agents A peptide having one of the following formulae (I), (II), (III) and (IV): ##STR1## or its functional derivatives, and a pharmaceutically acceptable salt thereof are disclosed. These peptides have a nootropic effect and are effective as antidementia a...	01/19/1993
5179221	Method for production of 3-cyano-3,5,5-trimethyl cyclohexanone A method for the production of 3-cyano-3,5,5-trimethyl cyclohexanone by the reaction of isophorone with hydrogen cyanide in the presence of a quaternary ammonium salt or quaternary phosphonium salt and a basic compound as a catalyst in the form dissolved ...	01/12/1993
5112947	Peptides, and antidementia agents containing the same Disclosed is a novel peptide having one of the formulae: ##STR1## (A and B are the amino acids: wherein if A is D- or L-Pro, B is Har or Cit; if A is D-Pro, B is D-Arg, and if B is D- or L-Arg, A is Sar, Pip, Aze or Arg) Asn-A-L-(D-)Pro-Arg-(Gly)n	05/12/1992
5106976	Fused pyrazine sulfoxide derivatives for use as antiulcer agents Novel sulfoxide derivatives having the formula (I) 5 or (V) show a gastric acid-secretion inhibitory effect: ##STR1## wherein each of R1 and R2 is hydrogen, lower alkyl, hydroxyalkyl, phenyl, phenylalkyl or cycloalkyl, R1	04/21/1992
5091403	Sulfinyl imidazole derivatives and antiulcer agents containing the same Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R1 is hydrogen or an alkyl group having 1-6 carbon atoms, R2 is an alkyl group having 2-6 carbon atoms substituted with an alkoxy group having 1-4 ca...	02/25/1992
5082943	Novel imidazole derivatives Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R1 and R2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R1 and R2 are combined to form a heterocycli...	01/21/1992

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Assignee: Nippon Chemiphar Co., Ltd.