Assignee: New York Blood Center

Location: NewYork, NY
No. of patents: 22

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Number	Title	Issue Date
7449295	Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instea...	11/11/2008
7241803	Compounds for inhibition of HIV infection by blocking HIV entry A group of compounds that inhibit HIV replication by blocking HIV entry was identified. Two representative compounds, designated NB-2 and NB-64, inhibited HIV replication (p24 production) with IC50 values	07/10/2007
6692751	Methods and systems for producing recombinant viral antigens The present invention relates to recombinant expression vectors which express segments of deoxyribonucleic acid that encode recombinant HIV and HCV antigens. These recombinant expression vectors are transformed into host cells and used in a method to expr...	02/17/2004
6548242	Process for the sterilization of biological compositions and the product thereby The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile protei...	04/15/2003
6451599	Monoclonal antibodies reactive with fibrin (ogen) degradation products generated by matrix metalloproteinases The invention provides monoclonal antibodies which are reactive with fibrin(ogen) degradation products (FDPS) generated by matrix metalloproteinases (MMPs), such as MMP-3, MMP-7, and membrane-type 1, MT1-MMP proteolysis of fibrinogen and cross-linked fibr...	09/17/2002
6416963	Cleaved fragments of fibrinogen The invention provides novel 댞 CX cleavage fragments of fibrinogen and methods for detecting and purifying these fragments. The method of the invention also includes a diagnostic method for determining fibrinolytic states or atherogenesi...	07/09/2002
6059749	Fibrin sealant glue-gun with insertable compressed gas cartridge and luer-type reservoir connectors An applicator for dispensing a substance comprising first and a second components of any mixture of fluids for either medical or other applications, in an exemplary application, a biological adhesive, such as a fibrin sealant, wherein the applicator compr...	05/09/2000
6020319	Nucleic acid based immunotherapy of chronic hepatitis B infection Method for DNA-based immunotherapy of mammalian subjects in the treatment of chronic hepatitis B infection through a series of injections of DNA transcription units encoding hepatitis B surface antigen followed by booster injections of a DNA transcription...	02/01/2000
5985275	ଲ-Lactoglobulin modified with aromatic anhydride compound for preventing HIV infection A composition is provided which comprises a protein or peptide containing lysines, wherein at least one of the lysines and/or the N-terminal amino group of the protein or peptide, such as casein, ଲ-lactoglobulin, powdered milk or whey, is modified b...	11/16/1999
5952009	Methods for preventing the transmission of or treating patients infected with herpesvirus A method of preventing the transmission of or treating herpesvirus, such as herpes simplex virus infection, or Chlamydia trachomatis comprising administering to a patient a composition which comprises: (i) a protein or peptide containing lysines and an N-...	09/14/1999
5824501	Nucleic acids of the bloom's syndrome gene The present invention provides a method for diagnosing BS as well as determining whether a subject is a carrier of a mutated BLM gene. The present invention also provides one or more single-stranded nucleic acid probes and antibodies which may be formulat...	10/20/1998
5824654	Method for delivery of nucleic acids to cells using hypericin polyamine complexes The invention provides improved methods for delivery of nucleic acids to cells, which comprise forming ternary complexes between a hydrophobic, membrane-binding anion such as hypericin; a polycation such as polylysine; and a nucleic acid such as DNA; and ...	10/20/1998
5814445	Method of identification and cloning differentially expressed messenger RNAs A method of identification of differentially expressed messenger RNA (mRNA) which consists of synthesizing from a set of sequences of mRNA sets of fragments of complementary DNA (cDNA), which are separated with the aid of gel electrophoresis and the pictu...	09/29/1998
5798206	Methods for screening of test compounds for inhibiting binding of a CD4-HIV 1 complex to a chemokine receptor A method for the screening of a test compound for inhibiting the binding of a CD4-HIV 1 complex to HIV-1 second receptors, comprising: (a) preparing a magnetic ligand by mixing a magnetic, CD4-containing substrate with HIV-1, (b) mixing the magnetic ligan...	08/25/1998
5759169	Fibrin sealant glue-gun An applicator for dispensing a first and a second component of a biological adhesive, such as a fibrin sealant, wherein the applicator comprises a housing having a first dispensing conduit for dispensing the first component and a second dispensing conduit...	06/02/1998
5756681	Method for providing contraception A method for preventing pregnancy in a mammal such as a human, by introducing into the reproductive tract of the mammal an effective contraceptive amount of beta-lactoglobulin, either alone or in combination with a pharmaceutically acceptable excipient, c...	05/26/1998
5589336	Diagnostic method and kit for determining Kell blood group genotype The invention provides a diagnostic method of determining Kell genotype by the identification of the molecular basis of a Kell polymorphism. Specifically, the invention provides a method for determining K1/K2 genotype with great accuracy, overcoming probl...	12/31/1996
5444044	Synthetic polypeptides as inhibitors of HIV-1 A synthetic HIV-1-based polypeptide as well as methods for topically inhibiting HIV-1 infectivity or replication. The polypeptide of the present invention has an amino acid sequence substantially corresponding to a specified region of the HIV-1IIIB	08/22/1995
5232844	Photodynamic inactivation of viruses in cell-containing compositions The present invention concerns the product produced by inactivating extracellular lipid enveloped pathogenic virus or intracellular pathogenic virus in a composition containing >1×109 cells/ml and said virus without incurring substantial disru...	08/03/1993
4803156	Peptide-beta-lactamase conjugates for enzyme-linked immunoassays A reagent for an ELISA determination of an antibody, the reagent comprising a peptide covalently linked to beta-lactamase. The reagent can be used in the following method to detect antibodies in a sample which involves a. contacting the sample with protein A l...	02/07/1989
4764369	Undenatured virus-free biologically active protein derivatives A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid...	08/16/1988
4481189	Process for preparing sterilized plasma and plasma derivatives A mammalian blood plasma or plasma derivative substantially free of active hepatitis B or non-A, non-B viruses is disclosed, the plasma being characterized by the presence of factor VIII, the percent by weight of denatured factor VIII to the sum of undena...	11/06/1984

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Assignee: New York Blood Center