Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 4954448 | Modulation of adenylate cyclase response Silicic acid modulates (i.e. enhances or inhibits) adenylate cycloase activity. This effect appears to be a general one, inasmuch as the modulation has occurred in all tissues studied. The results suggest that silicic acid can be used in human and veterin... | 09/04/1990 |
| 4931270 | Method for detecting dopaminergic diseases using fluorine-18 radiolabelled D2 dopamine receptor ligands Abnormalitites in the distribution of a dopamine D2 receptors in humans and other mammals are detected by (1) administering to a human or other mammal an amount of a 18 F-radiolabelled compound sufficient to be detected by a positron emis... | 06/05/1990 |
| 4920101 | Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes This invention provides compositions comprising a physiologically-active agent and a compound represented by the general formula ##STR1## wherein X may represent sulfur, oxygen or 2 hydrogen radicals; Y may represent --CH2 --, --NH-- or ox... | 04/24/1990 |
| 4917896 | Penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said sy... | 04/17/1990 |
| 4917688 | Bandage for transdermal delivery of systemically-active drug A transdermal delivery bandage and system is provided which includes a supply of topically and/or systemically-active drug, an adhesive for releasably securing the bandage to a dermal surface and control means which are separate from the supply of topical... | 04/17/1990 |
| 4912223 | 1,4-Dihydropyridines This invention provides novel compounds represented by the general formula: ##STR1## R1 and R2 are each independently selected from the group consisting of hydrocarbyl radicals and heteroatom-substituted hydrocarbyl radicals, wh... | 03/27/1990 |
| 4908262 | Article with microbiocidal solution A toilet seat cover is provided for preventing contact between the human bottocks and the toilet seat when the sheet is disposed and aligned with the toilet seat. A microbiocidal shield is created by the perspiration from the bottocks contacting a water-s... | 03/13/1990 |
| 4902676 | Compositions comprising N,N-dialkylalkanamides This invention provides compositions comprising a physiologically-active agent and a compound represented by the general formula ##STR1## wherein R1 and R2 are independently selected from the group consisting of alkyl radicals a... | 02/20/1990 |
| 4886783 | Penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said sy... | 12/12/1989 |
| 4886545 | Compositions comprising 1-substituted azacycloalkanes and their uses This invention provides compositions comprising a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and... | 12/12/1989 |
| 4885308 | Method and compositions for treatment of parkinsonism syndrome in mammals This invention provides a method for treating the symptoms of parkinsonism which comprises administering to a human or other mammal suffering from the symptoms of parkinsonism an effective amount of a compound selected from the group consisting of optical... | 12/05/1989 |
| 4882352 | Method for treating schizophrenia This invention provides a method for treating the symptoms of schizophrenia which comprises administering to a schizophrenic an effective amount of a compound selected from the group consisting of optically-active or racemic compounds represented by the g... | 11/21/1989 |
| 4880924 | Novel compounds and use thereof in selective cyclization process This invention relates to a selective process for preparing bicyclic lactam-lactone compounds wherein the rings are fused, i.e. the rings share at least two carbon atoms, or are isolated. In particular, the present invention provides a process for selecti... | 11/14/1989 |
| 4879275 | Penetration enhancers for transdermal delivery of systemic agent This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comnprising topically administering with said s... | 11/07/1989 |
| 4870173 | Lactam formation by a selective cyclization process This invention provides a process for preparing lactams, by selectively reacting a novel 1-hydrocarbyl-amino (or heteroatom-substituted hydrocarbylamino); 1,1-dicarboxylic acid, alkylesters; 1-hydrocarbyl (or heteroatom-substituted hydrocarbyl) carboxylic... | 09/26/1989 |
| 4849436 | 1,4-dihydropyridines This invention provides compounds useful for treating coronary insufficiency, hypertension, angina pectoris, cardiac arrythmia, heart attack or coronary vasospasm and represented by the general formula: ##STR1## R1 and R2 are ea... | 07/18/1989 |
| 4833150 | 1,4-dihydropyridines Compounds having calcium channel antagonist activity of the formula: ##STR1## wherein R1 and R2 are each independently amino, trifluoromethyl, pentafluoroethyl, alkoxy, lower alkenyl, or lower alkynyl or branched or unbranched l... | 05/23/1989 |
| 4808414 | Amide penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said sy... | 02/28/1989 |
| 4801586 | Penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said sy... | 01/31/1989 |
| 4782048 | Method for treating or preventing bovine mastitis The present invention provides a method for preventing or treating an animal, e.g. a cow, for mastitis, e.g. bovine mastitis, by administering to said animal a composition comprising copper ion and an organic compound having at least two hydroxyl groups a... | 11/01/1988 |
| 4762549 | Delivery of plant growth regulators The disclosure describes compositions and methods for improved delivery of plant growth regulators comprising contacting a plant with a composition comprising an effective amount of a plant growth regulator and an effective delivery enhancing amount of co... | 08/09/1988 |
| 4755535 | Compositions comprising 1-substituted azacycloalkenes This invention provides compositions comprising a physiologically-active agent and an azacycloalkene having at least one double bond in the ring and of the general formula ##STR1## wherein X and Y, each, may represent sulfur, oxygen or two hydrogen a... | 07/05/1988 |
| 4745640 | Toilet seat cover A toilet seat cover is provided for preventing contact between the human buttocks and the toilet seat when the sheet is disposed and aligned with the toilet seat. A microbiocidal shield is created by the perspiration from the buttocks contacting a water-s... | 05/24/1988 |
| 4743618 | Substituted 2-aminotetralins Novel compounds useful as dopamine receptor agonists for the treatment of various diseases of the central nervous system such as Parkinson's disease and related disorders having the structural formula ##STR1## where R2, R3 and R... | 05/10/1988 |
| 4722933 | Substituted 2-aminotetralins The invention provides compounds represented by the general formula ##STR1## where R2, R3 and R4 are each selected from the group consisting of H, and OA; A is H or ##STR2## R5 is selected from the gro... | 02/02/1988 |
| 4657925 | Method and compositions for reducing the intraocular pressure of mammals This invention provides a method for reducing the intraocular pressure in mammals which comprises administering an effective amount of a compound selected from the group consisting of compounds represented by the general formula: ##STR1## where ... | 04/14/1987 |
| 4652573 | Calcium antagonist N-hetero ester 1,4-dihydropyridines Compounds having calcium channel antagonist activity of the formula: ##STR1## wherein R1 and R2 are each independently amino, trifluoromethyl, pentafluoroethyl, alkoxy, lower alkenyl, or lower alkynyl or branched or unbranched l... | 03/24/1987 |
| 4591442 | Flash chromatography A flash chromatography apparatus and method for rapid, moderate-resolution separation of organic compounds. A solvent reservoir is pressurized with a gas, forcing solvent under pressure through tubing into and through a sorbent-packed chromatography colum... | 05/27/1986 |
| 4581374 | Contact lens preserving solution A method for sterilizing contact lenses and especially hydrophilic (soft) contact lenses comprising contacting a contact lens for a period of time sufficient to sterilize the lens with a substantially isotonic, aqueous composition having a pH between 6-9 ... | 04/08/1986 |
| 4581379 | Contact lens preserving solution A method for sterilizing contact lenses and especially hydrophilic (soft) contact lenses comprising contacting a contact lens for a period of time sufficient to sterilize the lens with a substantially isotonic, aqueous composition having a pH between 6-9 ... | 04/08/1986 |
| 4564628 | Substituted 2-aminotetralins Novel compounds useful as dopamine receptor agonists for the treatment of various diseases of the central nervous system such as Parkinson's disease and related disorders having the structural formula ##STR1## where R2, R3 and R... | 01/14/1986 |
| 4562075 | Penetration enhancers for transdermal drug delivery of systemic agents In a method for administering systemically active agents including therapeutic agents through the skin or other body membranes of humans and animals typically in the form of a transdermal device or formulation, the improvement comprising the use therewith... | 12/31/1985 |
| 4540691 | Dopamine agonists and use thereof Compounds are disclosed having the formula: ##STR1## wherein: R1 is H, OH, --OCH3, --CH2 OH, --NH2, --NHMe, --NHEt, --NMe2, --NEt2, ##STR2## R2 is H, --CH3, ... | 09/10/1985 |
| 4525199 | Method of improved pest control The disclosure describes a method for improved plant pest control comprising contacting a plant or plant pest with a composition comprising an effective amount of a plant pesticide and an effective delivery enhancing amount of compound having the structur... | 06/25/1985 |
| 4490389 | Contact lens preserving solution containing ascorbic acid or salts thereof A method for sterilizing contact lenses and especially hydrophilic (soft) contact lenses comprising contacting a contact lens for a period of time sufficient to sterilize the lens with a substantially isotonic, aqueous composition having a pH between abou... | 12/25/1984 |
| 4465692 | Selective D-2 dopamine receptor agonist A method of selectively stimulating D-2 dopamine receptors in humans comprising administering to a human requiring D-2 dopamine receptor stimulation, a therapeutically effective amount of 2-(N-phenylethyl-N-propylamino)-5-hydroxytetralin or a pharmaceutic... | 08/14/1984 |
| 4461638 | Delivery of plant nutrients The disclosure describes compositions and methods for improved delivery of plant nutrients comprising contacting a plant with a composition comprising an effective amount of a plant nutrient and an effective delivery enhancing amount of compound having th... | 07/24/1984 |
| 4446140 | Method and composition for treating mouth pain A method for treating mouth pain by administering to a human having such pain an effective mouth pain reducing amount of dextromethorphan, preferably as the hydrobromide.... | 05/01/1984 |
| 4444762 | Vehicle composition containing 1-substituted azacyclopentan-2-ones Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein ... | 04/24/1984 |
| 4424210 | Vehicle composition containing 1-substituted azacycloalkan-2-ones Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein ... | 01/03/1984 |
