Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7964217 | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor This invention relates to hydrolytically degradable gels of crosslinked poly(ethylene) glycol (PEG) structures. Addition of water causes these crosslinked structures to swell and become hydrogels. The hydrogels can be prepared by reacting two different PEG derivativ... | 06/21/2011 |
| 7910661 | Thiol-selective water-soluble polymer derivatives The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins. ... | 03/22/2011 |
| 7872082 | Method for preparing polymer maleimides Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the polymeric reagents, and conjugates prepared by polymeric reagents obtained by the described methods. ... | 01/18/2011 |
| 7851565 | Stabilized polymeric thiol reagents Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y—S—W]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S—W is a thiol, protected thiol, or thiol-reactive derivative. Pre... | 12/14/2010 |
| 7838595 | Water-soluble polymer alkanals The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepar... | 11/23/2010 |
| 7834138 | Segmented polymers and their conjugates Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are us... | 11/16/2010 |
| 7834088 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of spec... | 11/16/2010 |
| 7829074 | Hydroxypatite-targeting poly(ethylene glycol) and related polymers Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two te... | 11/09/2010 |
| 7790835 | Method of preparing maleimide functionalized polymers Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well a... | 09/07/2010 |
| 7786221 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P a... | 08/31/2010 |
| 7786133 | Chemically modified small molecules The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number... | 08/31/2010 |
| 7772357 | Hydrolytically degradable polymers and hydrogels made therefrom A water soluble polymer comprising multiple degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein the oligomer is branched. ... | 08/10/2010 |
| 7767784 | Methods for preparing polymeric reagents and compositions of polymeric reagents Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions. ... | 08/03/2010 |
| 7744861 | Multi-arm polymer prodrugs Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide ... | 06/29/2010 |
| 7723432 | Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol) The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an ami... | 05/25/2010 |
| 7714114 | Conjugates of an EPO moiety and a polymer Conjugates of an EPO moiety and one or more non-peptidic water-soluble polymers are provided. Typically, the non-peptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of ma... | 05/11/2010 |
| 7714088 | Poly(ethylene glycol) derivatives with proximal reactive groups An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and h... | 05/11/2010 |
| 7674879 | Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of... | 03/09/2010 |
| 7662365 | Polymer conjugates of opioid antagonists The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The inven... | 02/16/2010 |
| 7659361 | Maleamic acid polymer derivatives and their bioconjugates The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents an... | 02/09/2010 |
| 7655747 | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation... | 02/02/2010 |
| 7642323 | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers. A chromatographic purification step is not necessary in the method. In accordance with the method of the inven... | 01/05/2010 |
| 7608678 | Hydrolytically degradable polymers and hydrogels made therefrom A water soluble polymer is described, the water soluble polymer comprising multiple hydrolytically degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein the oligomer ... | 10/27/2009 |
| 7608663 | Method of preparing propionic acid-terminated polymers The invention provides methods for preparing polymers bearing a terminal propionic acid. The method involves first reacting a water soluble and non-peptidic polymer comprising at least one hydroxyl group with a tertiary alkyl acrylate in the presence of a catalyst t... | 10/27/2009 |
| 7608253 | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels... | 10/27/2009 |
| 7598338 | Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably mul... | 10/06/2009 |
| 7582284 | Particulate materials The present invention relates to active substances in particulate form, to methods for preparing them, to formulations containing them and to uses of such substances and formulations. A preferred embodiment is directed to particulate suspensions having improved floc... | 09/01/2009 |
| 7482024 | Compositions comprising an active agent The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention possesses superior aerosol properties and is thus preferred for aerosol... | 01/27/2009 |
| 7481212 | Increased dosage metered dose inhaler An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the contain... | 01/27/2009 |
| 7473433 | Pulmonary delivery of polyene antifungal agents The present invention provides spray-dried polyene compositions for oral inhalation to the lung. The polyene antifungal compositions demonstrate superior aerosol properties, do not exhibit appreciable degradation of the polyene upon spray-drying, and are useful in t... | 01/06/2009 |
| 7449201 | Storage stable power compositions of interleukin-4 receptor The present invention provides storage stable dry powder compositions of IL-4R. The powder compositions demonstrate superior chemical and physical stability over their solution counterparts, particularly upon storage under varying conditions of temperature and humid... | 11/11/2008 |
| 7422013 | Dry powder dispersing apparatus and methods for their use The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to ... | 09/09/2008 |
| 7393544 | Dispersion for pulmonary delivery of a bioactive agent Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between ... | 07/01/2008 |
| 7368102 | Pulmonary delivery of aminoglycosides The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of aminoglycosides. According to a preferred embodiment, compositions and method... | 05/06/2008 |
| 7326691 | Compositions comprising amphotericin B, methods, and systems A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another composition also includes particles including at least about 95 wt % of amphot... | 02/05/2008 |
| 7306787 | Engineered particles and methods of use Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In part... | 12/11/2007 |
| 7304750 | Systems and methods for non-destructive mass sensing The invention provides systems and methods for measuring the mass of a substance. In one method, energy is applied to a substance and a response resulting from the application of energy as measured. The mass of the substance is then determined based at least in part... | 12/04/2007 |
| 7300919 | Pulmonary delivery of active fragments of parathyroid hormone Systemic delivery of parathyroid hormone to a mammalian host is accomplished by inhalation through the mouth of a dispersion of an N-terminal fragment of PTH. It has been found that such respiratory delivery of the PTH fragment provides a pulsatile concentration pro... | 11/27/2007 |
| 7185651 | Flow regulator for aerosol drug delivery and methods An aerosolization device comprises a housing having a mouthpiece, and a flow path arrangement in fluid communication with the mouthpiece. The flow path arrangement has a flow regulating valve and a threshold valve, where the threshold valve is configured to open at ... | 03/06/2007 |
| RE39497 | Storage of materials A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be stored at ambient temperature. Recovery is by adding aqueous solution ... | 02/27/2007 |
